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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
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Diss Factsheets
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EC number: 619-856-7 | CAS number: 1056196-56-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Some information in this page has been claimed confidential.
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Data source
Referenceopen allclose all
- Reference Type:
- other: QSAR calculation report
- Title:
- Unnamed
- Year:
- 2 018
- Reference Type:
- other: Estimation software
- Title:
- ECOlogical Structure-Activity Relationship Model (ECOSAR) Class Program v1.11
- Author:
- US EPA
- Year:
- 2 012
- Bibliographic source:
- United States Environmental Protection Agency, Washington DC, USA; March 2012
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- ECOSAR v1.11: Estimation of acute and chronic toxicity to green algae for chemical class "Neutral Organic SAR (Baseline Toxicity)"
- GLP compliance:
- no
Test material
- Test material form:
- solid: particulate/powder
Constituent 1
Test organisms
- Test organisms (species):
- other: green algae
Study design
- Test type:
- not specified
- Water media type:
- freshwater
- Total exposure duration:
- 96 h
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 2.743 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- not specified
- Remarks on result:
- other:
- Remarks:
- The substance is within the applicability domain of the model.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Executive summary:
QPRF: ECOSAR v1.11
1.
Substance
See “Test material identity”
2.
General information
2.1
Date of QPRF
See “Data Source (Reference)”
2.2
QPRF author and contact details
See “Data Source (Reference)”
3.
Prediction
3.1
Endpoint
(OECD Principle 1)Endpoint
Toxicity to aquatic organisms:
- Green algae: 96-h EC50
- Green algae: chronic value
Dependent variable
- Green algae: 96-h EC50
- Green algae: chronic value
3.2
Model or submodel name
ECOSAR – Chemical Class: Neutral Organics:
- Green algae: 96-h EC50
- Green algae: chronic value
Model version
1.11
Reference to QMRF
QMRF: Estimation of Toxicity to Aquatic Organisms Using ECOSAR v1.11 (EPI Suite v4.11): Chemical Class: Neutral Organics: Green Algae 96-h EC50 and Chronic Value
Predicted value (model result)
See “Results and discussion”
Input for prediction
- For chemical identity: CAS number or SMILES
- Log Kow (optionally entered by user, or estimated by KOWWIN v1.68)
Descriptor values
See “Any other information on materials and methods incl. tables”
3.3
Algorithm
(OECD Principle 2)Domain: The complete training sets for ECOSAR’s estimation methodology are not available since some of the information is confidential; therefore, the description of a precise estimation domain for this methodology is not possible.
The substance is an organic chemical with a molecular weight ≤ 1000 g/mol.
Fulfilled
The substance is a member of the chemical class “Neutral Organics”.
Fulfilled
In case the log Kow is estimated via KOWWIN v1.68: The substance is within the estimation domain of KOWWIN v1.68.
Fulfilled
3.4
The uncertainty of the prediction
(OECD principle 4)Neutral Organics:
Effect level
n
r2
Green algae
96-h EC50
41 + 9
0.6782
chronic value
34 + 5
0.6971
3.5
The chemical mechanisms according to the model underpinning the predicted result
(OECD principle 5)The octanol/water partition coefficient (Kow) is the major physical-chemical attribute correlating a chemical structure to toxic effect for nonreactive neutral organic chemicals. The most frequently used relationship is the logarithm of the Kow value versus the median toxicity (LC50 and EC50) value.
If the log Kow value exceeds a model specific value (acute: 6.4; chronic: 8.0), or if the compound is solid and the LC50 exceeds the water solubility by 10X, no effects at saturation are predicted.
Members of the chemical class “Neutral Organics” act via simple nonpolar narcosis generally thought of as a reversible, drug-induced loss of conscience (general anesthesia) which is also referred to as baseline toxicity.
References
- US EPA (2012). On-Line ECOSAR User’s Guide.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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