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EC number: 620-092-1 | CAS number: 54024-17-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10 Jun 2020 - 09 July 2020
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Version / remarks:
- Adopted, July 17, 1992
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- (3aS,3bS,9aR,9bS,11aS)‐11a‐ethyl‐10‐methylidene‐1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH‐cyclopenta[a]phenanthrene‐1,7‐dione
- Cas Number:
- 54024-17-8
- Molecular formula:
- C20 H26 O2
- IUPAC Name:
- (3aS,3bS,9aR,9bS,11aS)‐11a‐ethyl‐10‐methylidene‐1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH‐cyclopenta[a]phenanthrene‐1,7‐dione
- Test material form:
- solid: particulate/powder
- Details on test material:
- Storage Conditions: In refrigerator (2-8°C)
Constituent 1
- Specific details on test material used for the study:
- Physical Description: Off-white powder
Storage conditions: In refrigerator (2-8°C)
Test item handling: No specific handling conditions required
Study design
- Oxygen conditions:
- anaerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source: The source of test organisms was activated sludge freshly obtained from a municipal
sewage treatment plant: 'Waterschap Aa en Maas', 's-Hertogenbosch, The Netherlands, receiving predominantly domestic sewage.
- Treatment: The freshly obtained sludge was kept under continuous aeration until further treatment. Before use, the sludge was coarsely sieved (1 mm). After treatment, the concentration of suspended solids (SS) was determined to be 3 g/L in the concentrated sludge as used for the test. The sludge was used as inoculum at a concentration of 10 mL per liter of mineral medium, leading to a final concentration SS of approximately 30 mg/L. - Duration of test (contact time):
- 28 d
Initial test substance concentrationopen allclose all
- Initial conc.:
- 80 mg/L
- Based on:
- ThOD
- Initial conc.:
- 29 mg/L
- Based on:
- test mat.
- Details on study design:
- TEST CONDITIONS
- Test vessels: 500 mL amber glass bottles. The end volume of medium was 244 mL, in order to obtain the required headspace-to volume ratio.
- Milli-RO water Tap-water purified by reverse osmosis (Milli-RO) and subsequently passed over activated carbon.
- CO2 absorber: Soda lime pellets (Merck, Darmstadt, Germany).
- Illumination: The test media were incubated in the dark.
- Suspended solid concentration: approximately 30 mg/L.
- Stock solution Mineral medium
A) 8.50 g KH2PO4: 21.75 g K2HPO4; 67.20 g Na2HPO4.12H2O; 0.50 g NH4Cl dissolved in Milli-RO water and made up to 1 L, pH 7.4 ± 0.2
B) 22.50 g MgSO4.7H2O dissolved in Milli-RO water and made up to 1 L.
C) 36.40 g CaCl2.2H2O dissolved in Milli-RO water and made up to 1 L.
D) 0.25 g FeCl3.6H2O dissolved in Milli-RO water and made up to 1 L.
_ Mineral medium 1 L mineral medium contains: 10 mL of solution (A), 1 mL of solutions (B) through (D) and Milli-RO water.
- Test temperature: Continuously measured in a vessel with Milli-RO water in the same climate-controlled incubator. The measure temperature was between 22 and 23°C
- pH: The pH was measured at the start and at the end of the test period. The pH at the start of the test was 7.4 and varied between 7.4 and 8.2 at the end of the test.
TEST DESIGN
- Test suspension: containing test item and inoculum (2 bottles).
- Inoculum blank: containing only inoculum (2 bottles)
- Procedural control: containing procedural control item and inoculum (1 bottle).
- Toxicity control: containing inoculum, test item and procedural control item in amounts contributing equally to the total ThOD (1 bottle).
- Test vessel preparation: At the start of the test (Day 0), test and/or procedural control item were added to the respective bottles. The volumes of suspensions were made up to 244 mL using inoculated mineral medium. Rubber gaskets containing an appropriate amount of CO2 absorber were inserted into each bottle. Subsequently, each bottle was sealed by screwing an automated respirometer head on top.
- Measuring equipment: Lovibond BD600-GLP manometric respirometry system, equipped with an inductive stirring system.
- Measurements: Oxygen consumption measurements were recorded automatically for 28 days
Reference substance
- Reference substance:
- other: Sodium acetate
Results and discussion
- Test performance:
- The relative biodegradation values calculated from the measurements performed during the
test period revealed no biologically relevant biodegradation of EMETAM by the end of the
test, based on ThOD (0 % and 1 % for bottle A and B, respectively).
In the toxicity control, more than 25 % biodegradation occurred within 14 days (44%, based
on ThOD). Therefore, the test item was considered not to inhibit microbial activity.
Functioning of the test system was checked by testing the procedural control item sodium
acetate, which showed a normal biodegradation curve.
% Degradationopen allclose all
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 1
- Sampling time:
- 28 d
- Remarks on result:
- other: Based on ThOD
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 28 d
- Remarks on result:
- other: Based on ThOD
BOD5 / COD results
- Results with reference substance:
- . The procedural control item (reference substance) was biodegraded by at least 78 % within 14 days.
Any other information on results incl. tables
pH valuea of different test media
Test medium | Day 0 | Day 28 |
Blank Control (A) | 7.5 | 7.4 |
Blank Control (B) | 7.5 | 7.4 |
Procedural Control | 7.5 | 8.2 |
Emetam (A) | 7.5 | 7.4 |
Emetam (B) | 7.5 | 7.4 |
Toxicity Control | 7.5 | 8.1 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- For detail see "Overall Remarks, Attachment"
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- In conclusion, EMETAM was not readily biodegradable under the conditions of the Manometric Respirometry Test.
- Executive summary:
In a manometric Respirometry test performed according to OECD guideline 301F and GLP principles, EMETAM was evaluated for its ready biodegradability. The test was performed in an aerobic aqueos medium containing activated sludge over a period of 28 days. The test item was tested in duplicate at a concentration of 29 mg/L, corresponding to a ThOD of 80 mg O2/L. The relative biodegradation values calculated from the measurements performed during the test period revealed no biological relevant biodegradation of EMETAM by the end of the test, based on ThOD (0% and 1% for bottle A and B, respectively). In the toxicity control 44% biodegradation occurred within 14 days, based on ThOD. Therefore, the test item was considered not to inhibit microbial activity. In conclusion, EMETAM was not readily biodegradable under the conditions of the Manometric respirometry test.
All validity criteria were met, the study is considered valid.
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