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Diss Factsheets
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EC number: 284-903-7 | CAS number: 84989-14-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Link to relevant study records
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- >= 85 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- body weight and weight gain
- clinical biochemistry
- Remarks on result:
- other: NOAEL refers to 0.07% dose group
- Key result
- Critical effects observed:
- yes
- Lowest effective dose / conc.:
- 145 mg/kg bw/day (actual dose received)
- System:
- hepatobiliary
- Organ:
- kidney
- liver
- other: body weight gain
- Treatment related:
- yes
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEL
- 85 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
- System:
- hepatobiliary
- Organ:
- kidney
- liver
- other: body weight gain
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In the OECD SIDS document (2005) the results of oral repeated dose toxicity studies are summarised as follows:
“Many studies have investigated the effects of repeated doses of LAS via the oral exposure route, mainly in the feed but also by gavage and through the drinking water. In a key study, groups of 8 or 9 rats of each sex were given LAS in drinking water at equivalent doses of 85, 145, and 430 mg/kg bw/day for 9 months (Yoneyama et al. 1976). Body weight gain was suppressed in the male 430 mg/kg bw/day group. Hematological examination revealed no significant change in any of the experimental groups, but a dose-related decrease in cholesterol level was seen in males. Significant decreases in the activities of glutamate-oxalate transaminase and lactate dehydrogenase were seen in males at the middle dose and a dose-related increase in the activity of glutamate-oxalate transaminase in females. A significant decrease in renal Na,K-ATPase was seen in the middle-dose group. No organ weight changes were observed. The NOAEL is 85 mg/kg bw/day.
Other studies show similar responses, with commonly reported effects at higher doses including diarrhea, suppression of body weight gain, increases in relative weight of the liver, changes in other organ weights, differences in enzymatic and serum-biochemical parameters (e.g., ATPase, LDH, G6Pase), and mild degeneration and desquamation of the tubular epithelium in the kidneys. Occasionally, other effects have been observed, including marked degeneration of renal tubes, proteinaceous degeneration in the liver, and effects on subcellular components (Yoneyama et al. 1972; Gupta et al. 1986; Mathur et al. 1986; Watari et al., 1977).”
The NOAEL derived from the key study (9 months dosing via drinking water) amounts to 85 mg/kg body weight/day. This value is just below the threshold value of 100 mg/kg/day indicated for classification as STOT RE 2. However, this threshold value applies to 3 months repeated dosing. In addition, none of the different linear alkylbenzene sulfonate compounds covered in the OECD SIDS document is classified for specific target organ toxicity. Accordingly, non-classification of calcium salt of linear alkyl benzenesulfonic acid (the target substance to be registered) is considered justified.
Justification for classification or non-classification
Based on the available toxicological information non-classification of calcium salt of linear alkyl benzenesulfonic acid (the target substance to be registered) is considered justified
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