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EC number: 269-824-8 | CAS number: 68334-33-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- fish short-term toxicity test on embryo and sac-fry stages
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- Early 1980's
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Results published in a scientific review. and peer reviewed in the European RAR.
- Justification for type of information:
- The primary component of all substances provide complete coverage of 68334-33-8. 68334-33-8 shares high structural similarity with 61789-80-8, 68783-78-8, 107-64-2, and 107-64-2. As 68334-33-8 is a UVCB its components encapsulate the other substances except for the counter ion (Cl-). In solution, the counter ions will dissociate from the parent structures. Therefore, we are comparing substances of equivalent nature. CAS 107-64-2 represents the C18 boundary of the 61789-80-8. ignoring the salt component CAS 61789-80-8 is equivalent to CAS 68334-33-8. 68783-78-8 is a worst case of both 68334-338 and 61789-80-8 since it is unsaturated and SP2 characterized carbon-carbon bonds are of higher reactivity. The primary component of CAS 112-02-7 is a substructure of all the other substances.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 210 (Fish, Early-Life Stage Toxicity Test)
- GLP compliance:
- no
- Analytical monitoring:
- yes
- Vehicle:
- yes
- Details on test solutions:
- The test species were exposed to five test concentrations of DTDMAC dissolved either in isopropanol and well water, or in triethylene glycol and river water. All effect concentrations are based on mean measured levels of the active ingredient.
- Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- Eggs obtained from the U.S. Fish and Wildlife Service at Columbia, Missouri
- Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 35 d
- Hardness:
- 28-31 mg/L CaCO3 (Well water)
62 mg/L CaCO3 (River water) - pH:
- 6.8-7.6 (Well water)
6.4-6.9 (River water) - Nominal and measured concentrations:
- Well water: solvent control; 0.006, 0.013, 0.024, 0.053, 0.09 mg/L
River water: solvent control; 0.04, 0.061, 0.13, 0.23, 0.45 mg/L
All effect concentrations are based on mean measured levels of the active ingredient. In well water the measured concentrations were equal to the nominal concentrations whereas in river water measured concentrations averaged 45-67% of the nominal concentrations. - Reference substance (positive control):
- not specified
- Duration:
- 35 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.23 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Remarks:
- in standard water
- Basis for effect:
- other: hatchability and mean weight of larvae
- Duration:
- 35 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.053 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Remarks:
- in river water
- Basis for effect:
- other:
- Remarks:
- survival, length and weight of larvae
- Conclusions:
- NOEC-35d = 0.23 mg/L (river water)
NOEC-35d = 0.053 mg/L (well water) - Executive summary:
To assess the long-term toxicity of DTDMAC embryo larval tests were conducted with Pimephales promelas in filtered well water and natural river water. Exposure was initiated within 48 hours after fertilization and continued through 30 days post hatch in a flow-through system. In well water the most sensitive parameters were mean percent survival, length and weight of larvae. The NOEC was 0.053 mg/L (measured concentration) after 34 days test duration. In river water the NOEC for the most sensitive parameters hatchability and mean weight of larvae was 0.23 mg/L after 33 days test duration. The river water (Town River) had the following characteristics: pH = 6.4 - 6.9, total hardness = 62 mg/L CaCO3, 9.4 mg/L suspended solids, 0.59 mg/l MBAS and triethyleneglycol was used as carrier solvent. The well water had a hardness
of 28 -31 mg/L CaCO3, pH = 6.8-7.6 and isopropanol was used as carrier solvent. In well water the measured concentrations were equal to the nominal concentrations whereas in river water measured concentrations averaged 45-67% of the nominal concentrations.
Reference
Description of key information
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.23 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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