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EC number: 251-932-1 | CAS number: 34316-64-8
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects up to the limit of water solubility for Brachydanio rerio (OECD 203)
Key value for chemical safety assessment
Additional information
One study is available on the short-term fish toxicity of dodecanoic acid hexyl ester (CAS No. 34316-64-8). Due to methodological deficiencies in this study, a study conducted with the structurally most similar substance, dodecanoic acid isooctyl ester (CAS No. 84713-06-4) was used to support the assessment.
The key study conducted with dodecanoic acid hexyl ester (CAS No. 34316-64-8) was performed according to the guideline ISO 7346-1 (similar to OECD 203), in a semi-static system, using Brachydanio rerio as test organism (Guhl, 2005). The fish were exposed to nominal test concentrations of 100, 300, 700, 1000, 3000 and 10000 mg/L during 96 hours. Significant mortality occurred at the two highest test concentrations, and an LC50 of 2200 mg/L was derived. However, the test concentrations in this study were far above the saturation limit of the test substance, and undissolved test material was not removed from the test solutions. The sudden increase in mortality from 0% at concentrations 100 – 1000 mg/L to 70% at 3000 mg/L is better explained by a physical effect, caused by the amount of undissolved material in the test solution, rather than a systemic toxic effect. It is therefore probable that no toxic effects occurred up to the limit of water solubility of the test substance.
The supporting study with dodecanoic acid isooctyl ester (CAS No. 84713-06-4) was performed according to OECD guideline 203 and GLP (Bogers, 1997). The test organism Cyprinus carpio was exposed to the test substance in a static system for 96 hours, at the nominal test concentration of 10,000 mg/L. Only the separated water phase was used in the test solutions. No mortality occurred at any of the test concentrations, and the LC50 was reported to be < 10,000 mg/L.
Thus, based on theabove mentioned results, and due to the structural and profile similarities of the two substances, as are explained with in the overall endpoint summary 6.1 it can be concluded that no toxicological short-term effects on fish are expected up tothe limit ofwater solubility for dodecanoic acid hexyl ester (CAS No. 34316-64-8).
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