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EC number: 251-932-1 | CAS number: 34316-64-8
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Readily biodegradable: 91.7% (CO2 evolution) in 28 days
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Since no studies are available on the biodegradability of dodecanoic acid, hexyl ester (CAS No. 34316-64-8), the assessment was based on studies conducted with the structurally most similar category members, for which data is available, isopropyl laurate (CAS No. 10233-13-3) and 2-ethylhexyl laurate (CAS No. 20292-08-4) as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. Further justification is given within the endpoint summary 5 and within the category justification section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was entered into IUCLID. Both read-across substances contain the same fatty acid as dodecanoic acid, hexyl ester. The alcohol is one carbon shorter for isopropyl laurate and two carbons longer for 2-ethylhexyl laurate. Since both read-across substances are readily biodegradable, it can be expected that dodecanoic acid, hexyl ester is readily biodegradable as well. Furthermore, as can be seen in the data matrix of the category justification in Section 13, all reliable data in the category support the hazard assessment for this endpoint, by showing a consistent pattern of results.
The key study with 2-ethylhexyl laurate (CAS No. 20292-08-4) was conducted according to OECD guideline 301 B and GLP (King, 1993), using non-adapted domestic activated sludge, as inoculum. During the 28-day test period, biodegradation reach 91.7%, based on CO2 evolution, and the 10-day window criterion was met.
The key study with isopropyl laurate (CAS No. 10233-13-3) was conducted according to OECD guideline 301 D and GLP (van Ginkel, 1993), using secondary effluent of activated sludge plant as inoculum. During the 28-day test period, biodegradation reach 67%, based on CO2 evolution, and the 10-day window criterion was met.
Thus, based on theabove mentioned results, and due to the structural and profile similarities of the substances, as are explained with in the overall endpoint summary 5 it can be concluded that dodecanoic acid, hexyl ester (CAS No. 34316-64-8) can be considered readily biodegradable according to OECD criteria.
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