Registration Dossier
Registration Dossier
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EC number: 247-569-3 | CAS number: 26266-58-0
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to a loading rate of 100 mg/L (OECD 202, Acartia tonsa); read-across
Key value for chemical safety assessment
Additional information
No studies are available on the toxicity of Anhydro-D-glucitol trioleate (CAS No. 26266-58-0) to aquatic invertebrates. The assessment was, therefore, based on studies conducted with the structurally similar category members Sorbitan oleate (CAS No. 1338-43-8) and Sorbitan, (Z)-9-octadecenoate (2:3) (CAS No. 8007-43-0), as part of a read-across approach. This is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. All three substances are Sorbitan esters of C18 unsaturated fatty acids. Sorbitan oleate mainly consists of monoester, Sorbitan, (Z)-9-octadecenoate (2:3) of di- and triester and Anhydro-D-glucitol trioleate of triester. Due to the lower degree of esterification, the read-across substances have smaller molecular size and higher bioavailability. They can, therefore be seen as a worst case assessment compared to anhydro-D-glucitol trioleate.
The key study conducted with Sorbitan, (Z)-9-octadecenoate (2:3) (CAS No. 8007-43-0) was performed according to the OECD Guideline 202 and GLP (Hudson, 2003). The test organism Acartia tonsa was exposed to the test substance in a static system for 48 hours, at nominal test concentrations of 1000, 1800, 3200, 5600 and 10000 mg/L. Immobilisation was observed at the highest test concentration, and an EC50 of 7756 mg/L was derived. Although the test solutions were prepared as water accommodated fractions (WAF), physical effects caused by undissolved test material cannot be excluded. The sudden increase in mortality from 0% at concentrations up to 1000 - 5600 mg/L to 100% at 10,000 mg/L, is more likely to be caused by the amount of undissolved test material in the test solution, leading to immobilisation of the daphnia, rather than a systemic toxic effect.
The saltwater key study conducted with Sorbitan oleate (CAS No. 1338-43-8) was performed according to the ISO (1990) Proposal for 14669 (1999) Water Quality: Determination of acute lethal toxicity to marine copepods (Copepoda,Crustacea) (Hudson, 1999). The test organism Acartia tonsa was exposed to the test substance in a static system for 48 hours, at nominal test concentrations of 1000, 1800, 3200, 5600 and 10000 mg/L.No immobilisation was observed and an EC50 of > 10000 mg/L was reported.
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