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EC number: 236-715-1 | CAS number: 13466-20-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11-Apr-2016 to 04-Aug-2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- July 27, 1995
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- May 31, 2008
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Ministerium für Arbeit, Integration und Soziales des Landes Nordrhein-Westfalen, Düsseldorf, Germany
- Type of method:
- flask method
- Specific details on test material used for the study:
- - Appearance: white crystalline powder
- Analytical purity: >92% based on 43 % BaO and 42 % P2O5
- Batch No.: 9000008613
- Expiration date of the lot/batch: April 23, 2017
- Storage conditions: Store dry in original tightly closed container at a well-ventilated cool place - Key result
- Water solubility:
- >= 27.16 - <= 28.42 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 30 g/L
- Temp.:
- 20 °C
- pH:
- >= 2.9 - <= 3
Reference
During the 1st main study the test material visually completely dissolved over three days of testing. In the 2nd main study undissolved white material was observed in the test item loaded vessels. The dissolved Ba concentrations indicate that all barium from the test item is dissolved. The precipitate is probably due to formation of phosphate species. Therefore, it was decided to quantify the dissolved phosphorous in respective samples.
After filtration of all samples, the solutions were clear. In order to verify this, the turbidity was measured in these samples.
The temperature in the thermostatically controlled incubation cabinet was monitored by a thermo data logger (Testo 175-T2, Testo AG, Leutkirch, Germany). The mean temperature in the 1st main test was 20.4 ± 0.2 °C. and 20.1 ± 0.1 °C in the 2nd main study.
The pH in test item loaded vessels in the 1st main test was in the range of 3.4 - 3.5, whereas the pH in method blanks ranged from 7.5 – 8.0. The pH in test item loaded vessels in the 2nd main test was in the range of 2.9 – 3.0, whereas the pH in method blanks ranged from 6.5 – 7.2.
The turbidity was measured after filtration to verify that only dissolved concentrations would get measured. The turbidity was always <1 NTU, indicating that no undissolved material was left after the filtration step.
Due to the very low LOQ (LOQ = 0.0144 µg Ba/L) of ICP-OES measurements, barium levels of method blanks are above the limit of quantification, but far below concentrations in test item loaded samples.
Phosphorous levels of method blanks are below the limit of detection (LOD = 39.1 µg P/L). Due to very low LOQ for Ba, few concentrations were above, but far below concentrations in test item loaded samples.
During the three days of testing in the first main study a complete dissolution of the test item was visually observed. Therefore the 1st main test cannot be used for determination of water solubility.
Barium concentrations in 2nd main tests were observed but this is due to a complete dissolution of Ba (see Table 1). However, the observed white precipitate in the 2nd main test is probably formed by phosphates. Therefore, the amount of dissolve P has also been quantified (see Table 2). Constant phosphorous concentrations according to the study guideline OECD 105 as well as the Regulation 440/2008/EC A.6 were measured during the study from day 1 to day 3.
The calculated amount of dissolved test item is compiled in Table 3 and Table 4 for 2nd main test in regard to Ba and P respectively.
Table 1 Measured barium concentrations in test samples in g/L in the 2nd main test (1,2 – duplicate vesssels; a,b –duplicate samples)
sample |
dilution |
measured |
measured* |
mean |
SD |
mean |
SD |
difference |
name |
factor |
Ba |
dilution |
Ba conc. |
Ba conc. |
Ba conc. |
Ba conc. |
between |
[µg/L] |
Ba |
per vessel |
per |
all |
all |
samplings |
||
[g/L] |
[g/L] |
vessel |
vessels |
vessels |
intervals |
|||
[g/L] |
[g/L] |
[g/L] |
[%] |
|||||
1a d1 |
100000 |
120.763 |
12.076 |
|||||
1b d1 |
100000 |
118.621 |
11.862 |
11.969 |
0.151 |
|||
2a d1 |
100000 |
120.842 |
12.084 |
|||||
2b d1 |
100000 |
118.393 |
11.839 |
11.962 |
0.173 |
11.965 |
0.005 |
|
1a d2 |
100000 |
124.248 |
12.425 |
|||||
1b d2 |
100000 |
121.512 |
12.151 |
12.288 |
0.193 |
|||
2a d2 |
100000 |
119.451 |
11.945 |
|||||
2b d2 |
100000 |
119.412 |
11.941 |
11.943 |
0.003 |
12.116 |
0.244 |
1.3 |
1a d3 |
100000 |
122.857 |
12.286 |
|||||
1b d3 |
100000 |
121.281 |
12.128 |
12.207 |
0.111 |
|||
2a d3 |
100000 |
124.683 |
12.468 |
|||||
2b d3 |
100000 |
121.937 |
12.194 |
12.331 |
0.194 |
12.269 |
0.088 |
1.3 |
Table 2 Measured phosphorous concentrations in test samples in g/L in the 2nd main test (1,2 – duplicate vesssels; a,b –duplicate samples)
sample |
dilution |
measured |
measured* |
mean |
SD |
mean |
SD |
difference |
name |
factor |
Ba |
dilution |
Ba conc. |
Ba conc. |
Ba conc. |
Ba conc. |
between |
[µg/L] |
Ba |
per vessel |
per |
all |
all |
samplings |
||
[g/L] |
[g/L] |
vessel |
vessels |
vessels |
intervals |
|||
[g/L] |
[g/L] |
[g/L] |
[%] |
|||||
1a d1 |
20000 |
258.9 |
5.178 |
|||||
1b d1 |
20000 |
242.9 |
4.858 |
5.018 |
0.226 |
|||
2a d1 |
20000 |
255.3 |
5.106 |
|||||
2b d1 |
20000 |
254.1 |
5.082 |
5.094 |
0.017 |
5.056 |
0.054 |
|
1a d2 |
20000 |
272 |
5.440 |
|||||
1b d2 |
20000 |
267.9 |
5.358 |
5.399 |
0.058 |
|||
2a d2 |
20000 |
253.1 |
5.062 |
|||||
2b d2 |
20000 |
261.6 |
5.232 |
5.147 |
0.120 |
5.273 |
0.178 |
4.3 |
1a d3 |
40000 |
132.5 |
5.300 |
|||||
1b d3 |
40000 |
121.7 |
4.868 |
5.084 |
0.305 |
|||
2a d3 |
40000 |
136.1 |
5.444 |
|||||
2b d3 |
40000 |
134 |
5.360 |
5.402 |
0.059 |
5.243 |
0.225 |
-0.6 |
Table 3 Calculated amount of solved test item d1– d3 in regard to Ba
mean |
SD |
percentage |
mean |
SD |
loading |
percentage |
|
vessel 1 |
12.15 |
0.17 |
40.13 |
30.19 |
0.41 |
30.00 |
100.6 |
vessel 2 |
12.08 |
0.22 |
30.10 |
0.55 |
30.01 |
100.3 |
|
all vessels |
12.12 |
0.15 |
30.19 |
0.378 |
Table 4 Calculated amount of solved test item d1– d3 in regard to P
mean |
SD |
percentage |
mean |
SD |
loading |
percentage |
|
vessel 1 |
5.17 |
0.20 |
18.68 |
27.66 |
1.09 |
30.00 |
92.2 |
vessel 2 |
5.21 |
0.16 |
18.68 |
27.92 |
0.88 |
30.01 |
93.0 |
all vessels |
5.19 |
0.12 |
18.68 |
27.79 |
0.63 |
The amount of barium bis(dihydrogenphosphate) dissolved was
calculated by:
= mean of measured values * 100 % / 18.68 %
mean calculated barium bis(dihydrogenphosphate) dissolved day 1 –
day 3:
Vessel 1: 27.66 ± 1.09 g/L
Vessel 2: 27.92 ± 0.88 g/L
Description of key information
water solubility: 27.79 ± 0.63 g/L at loading rate 30 g/L, 20 °C and pH 2.9 - 3.0 (OECD 105, EU A.6., flask method)
Key value for chemical safety assessment
- Water solubility:
- 27.79 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test item was determined using flask method according to OECD 105 and EU Method A.6. A solubility equilibrium was observed during the test with a loading of 30 g/L test item in regard to phosphorous.
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