Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 234-054-3 | CAS number: 10519-11-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation potential was evaluated in the EpiDerm™ Reconstructed Human Epidermis Model (OECD 439). Following 60 minute exposure to the undiluted test item, the mean relative absorbance values indicative of cell viability were unaltered (100.0% viability; threshold for irritancy: ≤ 50%), consequently the test item was not considered irritating to the skin.
Adhering to OECD TG 405 and GLP, an in vivo rabbit eye irritation study demonstrated mean cornea opacity, iris lesion, conjunctiva redness and conjunctiva oedema (chemosis) score of 0.0, 0.0, 1.0 and 0.7, respectively. All signs of irritation were reversed within 7 days and the test substance is not considered to be irritating to the eye
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation of the test item was evaluated with the EpiDerm™ Reconstructed Human Epidermis Model (2016). Cell viability of the multi-layered tissue culture of highly differentiated epidermal keratinocytes topically exposed to the test substance was evaluated using the MTT assay, which measures the conversion of 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyl-tetrazoliumbromide (MTT) into a blue formazan salt. Undiluted test item was applied to the EpiDerm™ tissue for 60 minutes, alongside a negative and positive control. The mean relative absorbance value of the test item, corresponding to the cell viability did not decrease (100.0%; threshold for irritancy: ≤ 50%), consequently the test item was not irritant to skin. The test item passed the MTT and Colour Interference pre-tests. Conducted according to OECD Test Guideline 439 and GLP, the study is considered to be reliable without restriction (Klimisch 1) and sufficient to fulfil the REACH Annex VII information requirement.
Eye irritation of the test item was tested in four female albino rabbits. An undiluted volume (0.1 mL) of the test item was administered to one eye, whilst the other eye served as a control (2000). Effects on the cornea, iris and conjunctiva were recorded at 1, 24, 48 and 72 hours and 7 days after application. The mean scores of cornea opacity, iris lesion, conjunctiva redness and conjunctiva oedema (chemosis) were 0.0, 0.0, 1.0 and 0.7, respectively. All animals were free of any signs of eye irritation after 7 days. According to the directive of the EEC commission 93/21/EEC (4 May 1993), the test item should not be classified as eye irritating. Conducted according to OECD Guideline 405 and EU Method B.5 and GLP, the study was considered to be reliable without restriction (Klimisch 1).
Justification for classification or non-classification
Two reliable (Klimisch 1) and GLP compliant studies are available to inform the irritation / corrosion classification of Decahydro-2-naphthyl acetate (2000; 2016). In the eye irritation study, effects of the test item on 4 rabbits were reversible within 7 days. Individual mean scores were not ≥ 1 for corneal opacity and iritis and not ≥ 2 for conjunctival redness and oedema in at least 3 of 4 animals. Thus, according to the "Guidance on the Application of the CLP Criteria" (ECHA 2015), the test item should not be classified as an eye irritant.
According to UN GHS and EU CLP Category 2, a substance is considered to be irritant to skin if the tissue viability after exposure and post-treatment incubation is ≤ 50%. In the EpiDerm skin irritation study, the mean relative absorbance value of the test item, corresponding to the cell viability, was 100%. Therefore, test item should not be classified as a skin irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.