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EC number: 232-030-7 | CAS number: 7783-84-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Data available for the structurally similar read across chemicals has been reviewed to determine the acute oral toxicity of the test chemical Ferric hypophosphite (7783-84-8).The studies are as mentioned below:
1.Acute oral toxicity study was performed in male and female wistar rats using test chemical according to OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method).No mortality was observed at dose 5000 mg/kg bw.Clinical signs of systemic toxicity or reaction to treatment included lethargy, uncoordinated movements and staining of the eye on day 1.No effects on body weight or weight gain were recorded. No macroscopic abnormalities were noted during necropsy.Hence,LD50 value was considered to be >5000 mg/kg bw,when wistar rats were treated with test chemical orally.
2.Acute oral toxicity study was performed in rats using test chemical.50% mortality was observed at dose 3850 mg/kg bw. Hence,LD50 value was considered to be 3850 mg/kg bw,when rats were treated with test chemical orally.
Thus, based on the above summarised studies,Ferric hypophosphite (7783-84-8)and it’s structurally similar read across substance, it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, Ferric hypophosphite (7783-84-8) cannot be classified for acute oral toxicity.Hence,based on the data available for the structurally similar read across, test chemical Ferric hypophosphite (7783-84-8)is not likely to be toxic atleast in the dose range of 3850->5000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- experimental data of read across substances
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on two acute oral toxicity studies as-
1.and 2. Acute Oral toxicity test was carried out to study the effects of the test chemicals on rodents - GLP compliance:
- not specified
- Test type:
- other: 1.acute toxic class method 2.no data available
- Limit test:
- no
- Specific details on test material used for the study:
- - Name of test material: Ferric hypophosphite
- IUPAC name: iron(3+) ion triphosphinate
- Molecular formula: FeO6P3
- Molecular weight: 250.8084 g/mole
- Smiles : [Fe+3].[O-]P=O.[O-]P=O.[O-]P=O
- Inchl: 1S/Fe.3H3O2P/c;3*1-3-2/h;3*3H2,(H,1,2)/q+3;;;/p-3
- Substance type: Inorganic
- Physical state: Solid powder (white to grey) - Species:
- rat
- Strain:
- other: 1.Wistar Crl: (Wi) BR 2.not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 1.Details on test animal
TEST ANIMALS
- Source:Charles River Deutschland, Sulzfeld, Germany
- Age at study initiation: Approximately 8 weeks old at time of dosing
- Weight at study initiation: Males: 268-310 g
Females: 194-205 g
- Housing: Groups of three by sex in polycarbonate cages with sawdust bedding
- Diet (e.g. ad libitum): Standard pelleted laboratory diet supplied by Carfill Quality BVBA,Belgium ad libitum
- Water (e.g. ad libitum): Ad libitum access to tap water.
- Acclimation period: At least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 °C
- Humidity (%):55 ± 15 %
- Air changes (per hr): 15 per hour
- Photoperiod (hrs dark / hrs light): Alternating 12 hour light/dark cycle
2.not specified - Route of administration:
- oral: unspecified
- Vehicle:
- other: propylene glycol
- Details on oral exposure:
- no data available
- Doses:
- 1.5000 mg/kg bw
2.3850 mg/kg bw - No. of animals per sex per dose:
- 1.Total: 6 animals
5000 mg/kg bw:3 males and 3 females
2.not specified - Control animals:
- not specified
- Details on study design:
- 1.Details on study design:
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights
2.not specified - Statistics:
- no data available
- Preliminary study:
- no data available
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 850 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no mortality was observed
- Mortality:
- 1.No mortality was observed at dose 5000 mg/kg bw in treated rats
2.50% mortality was observed at dose 3850 mg/kg bw in treated rats - Clinical signs:
- other: 1.Clinical signs of systemic toxicity or reaction to treatment included lethargy, uncoordinated movements and staining of the eye on day 1. 2.No data available
- Gross pathology:
- 1.No macroscopic abnormalities were noted during necropsy.
2.No data available - Other findings:
- no data available
- Interpretation of results:
- other: not classified
- Conclusions:
- The test chemical Ferric hypophosphite (7783-84-8) is not likely to be toxic atleast in the dose range of 3850->5000 mg/kg bw.
- Executive summary:
Data available for the structurally similar read across chemicals has been reviewed to determine the acute oral toxicity of the test chemical Ferric hypophosphite (7783-84-8).The studies are as mentioned below:
1.Acute oral toxicity study was performed in male and female wistar rats using test chemical according to OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method).No mortality was observed at dose 5000 mg/kg bw.Clinical signs of systemic toxicity or reaction to treatment included lethargy, uncoordinated movements and staining of the eye on day 1.No effects on body weight or weight gain were recorded. No macroscopic abnormalities were noted during necropsy.Hence,LD50 value was considered to be >5000 mg/kg bw,when wistar rats were treated with test chemical orally.
2.Acute oral toxicity study was performed in rats using test chemical.50% mortality was observed at dose 3850 mg/kg bw. Hence,LD50 value was considered to be 3850 mg/kg bw,when rats were treated with test chemical orally.
Thus, based on the above summarised studies,Ferric hypophosphite (7783-84-8)and it’s structurally similar read across substance, it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, Ferric hypophosphite (7783-84-8) cannot be classified for acute oral toxicity.Hence,based on the data available for the structurally similar read across, test chemical Ferric hypophosphite (7783-84-8)is not likely to be toxic atleast in the dose range of 3850->5000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- data is from secondary source
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Data available for the structurally similar read across chemicals has been reviewed to determine the acute oral toxicity of the test chemical Ferric hypophosphite (7783-84-8).The studies are as mentioned below:
1.Acute oral toxicity study was performed in male and female wistar rats using test chemical according to OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method).No mortality was observed at dose 5000 mg/kg bw.Clinical signs of systemic toxicity or reaction to treatment included lethargy, uncoordinated movements and staining of the eye on day 1.No effects on body weight or weight gain were recorded. No macroscopic abnormalities were noted during necropsy.Hence,LD50 value was considered to be >5000 mg/kg bw,when wistar rats were treated with test chemical orally.
2.Acute oral toxicity study was performed in rats using test chemical.50% mortality was observed at dose 3850 mg/kg bw. Hence,LD50 value was considered to be 3850 mg/kg bw,when rats were treated with test chemical orally.
Thus, based on the above summarised studies,Ferric hypophosphite (7783-84-8)and it’s structurally similar read across substance, it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, Ferric hypophosphite (7783-84-8) cannot be classified for acute oral toxicity.Hence,based on the data available for the structurally similar read across, test chemical Ferric hypophosphite (7783-84-8)is not likely to be toxic atleast in the dose range of 3850->5000 mg/kg bw.
Justification for classification or non-classification
Based on the above experimental studies on Ferric hypophosphite (7783-84-8)and it’s structurally similar read across substances, it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation,Ferric hypophosphite (7783-84-8)cannot be classified for acute oral toxicity.
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