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Diss Factsheets
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EC number: 225-464-3 | CAS number: 4861-19-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Urea phosphate is dissociated into urea and phosphoric acid. Phosphoric acid shows a lower toxicity level in oral toxicity, while no dermal and inhalation studies are available and thus not required because the substance is classified as skin corrosive.
Acute toxicity: oral - An oral LD50 of 1.70 mL/100 g body weight in SPF-Wister K rats for a 10% solution of 75.4% thermal phosphoric acid was observed.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 600 mg/kg bw
Additional information
Urea phosphate will directly dissociate into urea and phosphoric acid in an aqueous environment.
Acute toxicity: oral
An LD50 of 1.70 ml/100 g body weight in SPF-Wister K rats for a 10% solution of 75.4% thermal phosphoric acid (study performed according to OECD Guideline 423) was observed. This is approximately 2600 mg/kg bw.
Urea is of very low acute oral toxicity in the rat with an LD50 of 14300 mg/kg bw.
Acute toxicity: inhalation No reliable data are available for phosphoric acid and urea. Urea phosphate has a low vapour pressure and a high particle size, resulting in negligible inhalation exposure possible. In addition, urea phosphate is classified as corrosive to skin and thus no study is required. Acute dermal toxicity Phosphoric acid is classified as corrosive to the skin. There is no concern for the dermal route of exposure as personal protective equipment is used (gloves and googles) in the production and use of phosphoric acid. In addition key studies are available for acute oral toxicity and acute inhalation toxicity. Therefore, there is no need to perform an acute dermal toxicity test.Justification for classification or non-classification
Based on the available data urea phosphate should not be classifed according to Directive 67/548/EC and the CLP Regulation (EC) No 1272/2008 for this endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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