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EC number: 224-079-8 | CAS number: 4196-86-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15.01.2018 - 14.02.2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-C (Determination of the "Ready" Biodegradability - Carbon Dioxide Evolution Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Name: Pentaerythritol tetrabenzoate
Batch no.: D170724-05
Appearance: off-white solid
Composition: Pentaerythritol tetrabenzoate >96%
CAS No.: 4196-86-5
EINECS-No.: 224-079-8
Molecular formula: C33H28O8
Molecular weight: 552.576 g/mol
Purity: >96%
Homogeneity: homogeneous
Expiry date: Nov. 2018
Storage: Room Temperature (20 ± 5°C) - Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- Activated sludge from a biologic sewage treatment plant was used as inoculum. The chosen plant treats mostly domestic sewage. The sludge was taken from the activation basin of the ESN (Stadtentsorgung Neustadt) sewage treatment plant, Im Altenschemel, NW-Lachen-Speyerdorf. Date of collection: 12. Jan. 2018, batch no: 20180112. The sludge was filtrated, washed with test medium (2x) and re-suspended in test medium. It was then aerated until use. The dry matter was determined to contain 4900 mg of suspended solids/L.
- Duration of test (contact time):
- ca. 28 d
- Initial conc.:
- >= 28 - <= 28.7 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- The medium was prepared from the stock solutions. The stock solution of the positive control was prepared and its DOC was measured. The inoculum was taken from its source, washed, aerated and the dry matter was determined. The test vessels were filled with medium and inoculum. Then, all flasks were aerated for 72 hours with purified, CO2-free, moistened air to purge the system of CO2.
The test vessels were aerated with purified (by activated charcoal), CO2-scrubbed, moistened air. The scrubbing of carbon dioxide was achieved by bubbling the purified air through a flask containing 1.5 M NaOH. To control the absence of CO2, the air was then led through a flask containing a solution of Ba(OH)2 before reaching the test vessels. Magnetic stirrers were used to prevent deposition of inoculum. The emitted CO2 was trapped in 0.25 M NaOH. Two scrubbers containing 100 mL each were connected in series to the test vessels. The initial IC value of the 0.25 M NaOH was separately determined in each flask.
From each front scrubber flask, 10 samples were taken in order to determine the emitted CO2 (on day 0, 2, 4, 7, 9, 11, 14, 18, 23 and 29). The sample volume was 1 mL. The resulting change in the volume of the front flask was considered in the calculation of emitted CO2. On day 28, 5 mL HCl 2 M was added to each test flask in order to drive off dissolved CO2. On day 29, samples from both scrubber flasks were taken. - Reference substance:
- aniline
- Test performance:
- All validity criteria were met.
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- ca. 3
- Sampling time:
- 28 d
- Details on results:
- The test item Pentaerythritol tetrabenzoate is considered as “not readily biodegradable“.
The degree of biodegradation reached 3 % after 28 days.
The 10-day-window was not detected.
Degradation missed 60 % within 28 days, too. Therefore, the test item is considered as “not ultimately biodegradable within 28 days”, as well.
The abiotic degradation reached 0.6 %. - Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The test item Pentaerythritol tetrabenzoate can be considered as “not readily biodegradable”. Degradation missed 60% within 28 days, though. Therefore, the test item is considered as “not ultimately biodegradable within 28 days”, as well. No observations were made which might cause doubts concerning the validity of the study outcome. The result of the test can be considered valid.
- Executive summary:
The test item Pentaerythritol tetrabenzoate (CAS.No.: 4196-86-5) was tested for biodegradation following OECD 301B and Method C.4 -C using a concentration of nominally 20 mg organic carbon/L (corresponding to 27.9 mg Pentaerythritol tetrabenzoate/L) in test medium. Aniline was chosen as positive control. Activated sludge was used as inoculum (concentration in the test 25.0 mg dry matter/L). The test was left running for 28 days. All validity criteria were met. Degradation of the positive control was 80 % after 9 days. The following data were determined for the test item Pentaerythritol tetrabenzoate:
No degradation within the 10 -day-window was detected. Degradation at the end of the test was 3%. Ready biodegradability is defined in the guidelines as degradation surpassing 60% within 10 days after reaching a level of 10 %. Therefore, when applying the 10-day-window, the test item Pentaerythritol tetrabenzoate is not readily biodegradable following OECD 301B and EU C.4-C respectively. As degradation missed 60% in the course of the test, Pentaerythritol tetrabenzoate is considered as not ultimately biodegradable, as well.
Reference
Description of key information
The test item Pentaerythritol tetrabenzoate (CAS.No.: 4196-86-5) was tested for biodegradation following OECD 301B and Method C.4 -C using a concentration of nominally 20 mg organic carbon/L (corresponding to 27.9 mg Pentaerythritol tetrabenzoate/L) in test medium. No degradation within the 10 -day-window was detected. Degradation at the end of the test was 3%. When applying the 10-day-window, the test item Pentaerythritol tetrabenzoate is not readily biodegradable following OECD 301B and EU C.4-C respectively. As degradation missed 60% in the course of the test, Pentaerythritol tetrabenzoate is considered as not ultimately biodegradable, as well.
Key value for chemical safety assessment
Additional information
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