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EC number: 220-290-4 | CAS number: 2702-72-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
No data was available on the sensitizing potential of the test substance. Therefore, data of a structural analogous substance, dimethylammonium 2,4-dichlorophenoxyacetate (CAS 2008-39-1), was used for read-across.
The assessment of systemic effects of salts of 2,4-D is based on data generated with 2,4-D acid. This read across is justified because 2,4-D acid and its salts are toxicologically equivalent once they have entered the system. This is due to the only diffusion-limited rate of reaching the acid-base equilibrium between the protonated acid and its deprotonated salt form in an aqueous environment like the human body. Thus, salts of 2,4-D will exert the same systemic effects as the corresponding acid.
The skin sensitisation potential of dimethylammonium 2,4-dichlorophenoxyacetate (CAS 2008-39-1) was evaluated in guinea pigs according to OECD Guideline 406 (Skin Sensitisation) following the protocol of the Guinea Pig Maximization Test ( Magnusson & Kligman) (RA-S, CAS 2008-39-1, Key, Kita, 1998, Aminopielik 600, skin sensitisation, RL2). 8 Male and 4 female animals in the treated group and 5 males and 1 female in the control group were induced by intradermal injection and epicutaneous application of the test substance. For intradermal induction, a series of three intradermal injections were conducted with either a 1:1 mixture (v/v) of Freund's complete adjuvant (FCA) and water, a 1:1 mixture (v/v) of 1% water solution of the test substance and FCA in water (1:1 v/v) or a 1:1 mixture (v/v) of 1% water solution of the test substance and FCA in water (1:1 v/v). Control animals received water instead of the test substance. These injections were conducted on day 0 of the experiment. 24 before topical induction on day 7, 0.5 ml of 10% sodium lauryl sulfate in vaseline was applied to the test area of the animals in order to create a local irritation. The induction by topical application was conducted with a 50% solution of the test substance which was applied to the test area of the animals for 48 h under occlusive conditions. The challenge was conducted 14 days after last induction application by applying a 40% solution of the substance for 24 h to the left flank of the animal under occlusive conditions. Animals were evaluated for skin reactions 24, 48 and 72 h after challenge.
5 test animals (42%) showed a discrete erythema at the left flank whereas the control animals did not react to the challenge exposure. These effects observed were not reversible within the time of observation (72 h).
On the basis of this study,sodium 2,4-dichlorophenoxyacetate (CAS 2702-72-9)is classified as sensitising to the skin under the conditions tested.
Migrated from Short description of key information:
RA-S, CAS 2008-39-1, Key, Kita, 1998, Aminopielik 600, skin sensitisation, RL2 - sensitising
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
No data on respiratory sensitisation was available.
Justification for classification or non-classification
According to the DSD (67/548/EEC) and CLP (EC No. 1272/2008) criteria for classification and labelling of dangerous substances sodium 2,4-dichlorophenoxyacetate (CAS 2702-72-9)is classified as sensitising to the skin.
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