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EC number: 218-638-5 | CAS number: 2210-25-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Vapour pressure
Administrative data
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
- Principles of method if other than guideline:
- In the static process, at thermodynamic equilibrium, the vapour pressure established in a closed system is determined at a specified temperature. This method is suitable for one component and multicomponent solids and liquids.
Recommended range:
10 up to 105 Pa.
Apparatus
The apparatus comprises a container for the sample installed in a heater assembly used to regulate the temperature of the sample. The container also includes a magnetic stirrer bar and a thermocouple for measuring the temperature of the sample. The apparatus also includes a pressure transducer to measure the pressure.
The sample is charged to the container which is then closed and the temperature is reduced (if required) sufficiently for degassing. The temperature must be low enough to ensure that the air is sucked out, but (in the case of multiple component system) it must not alter the composition of the material. If required, equilibrium can be established more quickly by stirring. The sample can be super cooled with e.g. liquid nitrogen (taking care to avoid condensation of air or pump fluid) or a mixture of ethanol and dry ice. For low temperature measurements a temperature regulated bath connected to an ultra-cryomat can be used.
The sample container is then installed in the heater assembly, the high-vacuum pump is attached to the containment vessel and vacuum is applied to the sample container via the bypass valve. Suction is applied for several minutes to remove the air. If necessary, the degassing operation must be repeated several times.
The sample is then heated, the vapour pressure increases and the vapour pressure is read off directly on the pressure indicator. - GLP compliance:
- not specified
- Type of method:
- static method
Test material
- Reference substance name:
- N-isopropylacrylamide
- EC Number:
- 218-638-5
- EC Name:
- N-isopropylacrylamide
- Cas Number:
- 2210-25-5
- Molecular formula:
- C6H11NO
- IUPAC Name:
- N-isopropylacrylamide
- Test material form:
- solid: flakes
- Details on test material:
- N-Isopropylacrylamide (NIPAM)
Batch No. 2161004
Constituent 1
- Specific details on test material used for the study:
- Purity: 99.41%
Results and discussion
Vapour pressureopen allclose all
- Key result
- Test no.:
- #1
- Temp.:
- 25 °C
- Vapour pressure:
- 11 hPa
- Key result
- Test no.:
- #2
- Temp.:
- 50 °C
- Vapour pressure:
- 36 hPa
- Key result
- Test no.:
- #3
- Temp.:
- 75 °C
- Vapour pressure:
- 41 hPa
- Key result
- Test no.:
- #4
- Temp.:
- 100 °C
- Vapour pressure:
- 512 hPa
- Key result
- Test no.:
- #5
- Temp.:
- 125 °C
- Vapour pressure:
- 559 hPa
- Remarks on result:
- other: Potentially polymerising
Any other information on results incl. tables
Experimental results
Temperature, °C |
Vapour Pressure, hPa |
25 |
11 |
50 |
36 |
75 |
41 |
100 |
512 |
125 |
559* |
*potentially polymerising
Applicant's summary and conclusion
- Conclusions:
- The vapour pressure of NIPAM was found to be:
Temperature, °C Vapour Pressure, hPa
25 11
50 36
75 41
100 512
125 559 - Executive summary:
The vapour pressure of a substance is defined as the saturation pressure above a solid or liquid substance. At the thermodynamic equilibrium, the vapour pressure of a pure substance is a function of temperature only.
There is no single measurement procedure applicable to the entire range of vapour pressures. Therefore, several methods are recommended to be used for the measurement of vapour pressure from < 10-4 to 105 Pa.
Impurities will usually affect the vapour pressure, and to an extent which depends greatly upon the kind of impurity.
For determining the vapour pressure, several methods can be applied in different vapour pressure ranges. For each method, the vapour pressure is determined at various temperatures. In a limited temperature range, the logarithm of the vapour pressure of a pure substance is a linear function of the inverse of the temperature.
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