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EC number: 216-223-3 | CAS number: 1530-32-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- experimental data of read across substances
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on two hydrolysis studies as-
1., 2. and 3. - GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material : Ethyltriphenylfosfonium bromide
- Molecular formula : C20H20P.Br
- Molecular weight : 371.256 g/mol
- Smiles notation : [P+](c1ccccc1)(c1ccccc1)(c1ccccc1)CC.[BrH-]
- InChl : 1S/C20H20P.BrH/c1-2-21(18-12-6-3-7-13-18,19-14-8-4-9-15-19)20-16-10-5-11-17-20;/h3-17H,2H2,1H3;1H/q+1;/p-1
- Substance type: Organic
- Physical state: Solid - Radiolabelling:
- not specified
- Analytical monitoring:
- yes
- Remarks:
- 1. Yes, 2. and 3. No data available
- Buffers:
- 1. - Composition of buffer: pH 4: 45 mL of 0.1 mol/L NaOH and 250 mL of 0.1 mol/L monopotassium citrate were filled up to 500 mL with purified water.pH 7: 148.15 mL of 0.1 mol/L NaOH and 250 mL of 0.1 mol/L monopotassium phosphate were filled up to 500 mL with purified water.pH 9: 106.5 mL of 0.1 mol/L NaOH, 250 mL of 0.1 mol/L H3BO3 in 0.1 mol/L KCL.
2. and 3. No data available - Estimation method (if used):
- 1. and 2. No data available
3. Structure estimation method - Details on test conditions:
- 1. Test substance was added in the test water of pH 4, pH 7 and pH 9 to be the test concentration of about 0.05 mg/L. These test solutions were shook for 5 days at 50 degree C. After that, the test concentration of each test water was measured and compared with the initial concentration.
2. and 3. No data available - Duration:
- 5 d
- Temp.:
- 50 °C
- Remarks:
- 1. The study was performed at pH 4, 7 and 9, respectively.
- Remarks:
- 2. and 3. No data available
- Positive controls:
- not specified
- Negative controls:
- not specified
- Transformation products:
- not specified
- % Recovery:
- 96.5
- pH:
- 5
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- other: 1. %recovery: 98.5%, 94.6% (average 96.5%)
- % Recovery:
- 97.5
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- other: 1. % recovery: 98.0%, 96.9% (average 97.5%)
- % Recovery:
- 98.6
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- other: 1. % recovery: 96.5%, 101% (average 98.6%)
- Remarks on result:
- other: 2. and 3. No data available
- Temp.:
- 50 °C
- DT50:
- > 5 d
- Remarks on result:
- other: 1. The study was performed at pH 4, 7 and 9, respectively.
- Remarks on result:
- other: 2. Although half-life value of test chemical was not known, but it was noted that chemical is not susceptible to hydrolysis.
- pH:
- 7
- DT50:
- 1.4 yr
- Type:
- second order
- Remarks on result:
- other: 3. Hydrolysis rate constant is 0.16 L/mol-sec.
- pH:
- 8
- DT50:
- 51 d
- Type:
- second order
- Remarks on result:
- other: 3. Hydrolysis rate constant is 0.16 L/mol-sec.
- Details on results:
- 1. Test chemical was reported to be hydrolytically stable at pH 4, 7 and 9, respectively at a temperature of 50⁰C for 5 days.
2. and 3. No data available - Validity criteria fulfilled:
- not specified
- Conclusions:
- On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 5 days at pH 4, 7 and 9 & at a temperature of 50⁰C or 1.4 yrs and 51 days at pH 7 and 8 with a second order hydrolysis rate constant of 0.16 L/mol-sec, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable.
- Executive summary:
Data available for the test chemical has been reviewed to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:
The half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C and pH of 4, 7 and 9, respectively. The average percentage recovery of the test chemical after 5 days was determined to be 96.5, 97.5 and 98.6% at pH 4, 7 and 9, respectively. As no hydrolysis of test chemical was observed for a period of 5 days, the half-lives was determined to be > 5 days at pH 4, 7 and 9 & at a temperature of 50⁰C, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.
For the test chemical, the hydrolysis half-life was determined. Although half-life value of test chemical was not known, but it was noted that chemical is not susceptible to hydrolysis and thus it was reported to be hydrolytically stable. On the basis of this, test chemical isconsidered to be not hydrolysable.
In an another study, the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.16L/mol-sec with a corresponding half-lives of 1.4 yrs and 51 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 5 days at pH 4, 7 and 9 & at a temperature of 50⁰C or 1.4 yrs and 51 days at pH 7 and 8 with a second order hydrolysis rate constant of 0.16 L/mol-sec, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable.
Reference
1.
Result:
pH |
Initial concentration |
Concentration after 5 days |
Residue |
Average residue |
pH 4.0 |
0.0392 mg/L |
0.0386 mg/L |
98.5 % |
96.5 % |
0.0371 mg/L |
94.6 % |
|||
pH 7.0 |
0.0398 mg/L |
0.0390 mg/L |
98.0 % |
97.5 % |
0.0386 mg/L |
96.9 % |
|||
pH 9.0 |
0.0391 mg/L |
0.0378 mg/L |
96.5 % |
98.6 % |
0.0394 mg/L |
101 % |
In all pHs, the residues of the test substance were more than 90 %.
2. and 3. No data available
Description of key information
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 5 days at pH 4, 7 and 9 & at a temperature of 50⁰C or 1.4 yrs and 51 days at pH 7 and 8 with a second order hydrolysis rate constant of 0.16 L/mol-sec, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable.
Key value for chemical safety assessment
Additional information
Data available for the test chemical has been reviewed to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:
The half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C and pH of 4, 7 and 9, respectively. The average percentage recovery of the test chemical after 5 days was determined to be 96.5, 97.5 and 98.6% at pH 4, 7 and 9, respectively. As no hydrolysis of test chemical was observed for a period of 5 days, the half-lives was determined to be > 5 days at pH 4, 7 and 9 & at a temperature of 50⁰C, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.
For the test chemical, the hydrolysis half-life was determined. Although half-life value of test chemical was not known, but it was noted that chemical is not susceptible to hydrolysis and thus it was reported to be hydrolytically stable. On the basis of this, test chemical isconsidered to be not hydrolysable.
In an another study, the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.16L/mol-sec with a corresponding half-lives of 1.4 yrs and 51 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 5 days at pH 4, 7 and 9 & at a temperature of 50⁰C or 1.4 yrs and 51 days at pH 7 and 8 with a second order hydrolysis rate constant of 0.16 L/mol-sec, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable.
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