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EC number: 215-960-8 | CAS number: 1461-25-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 March to 15 April 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.6 (Degradation: Chemical Oxygen Demand)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- ZK 24.942
- IUPAC Name:
- ZK 24.942
- Reference substance name:
- Tetrabutyltin
- EC Number:
- 215-960-8
- EC Name:
- Tetrabutyltin
- Cas Number:
- 1461-25-2
- Molecular formula:
- C16H36Sn
- IUPAC Name:
- tetrabutylstannane
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): ZK 24.942
- Physical state: clear liquid
- Analytical purity: 99.93 %
- Lot/batch No.: W91/14
- Expiration date of the lot/batch: 5 Sept 1993
- Storage condition of test material: Room temperature in darkness
Constituent 1
Constituent 2
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, predominantly domestic (adaptation not specified)
- Details on inoculum:
- A sample of activated sewage sludge was collected from the sewage treatment farm. The sample was allowed to settle for approx 30 minutes and the supernatant was filtered through Whatman GFA coarse filter paper (first 250 mL discarded). The filtrate was maintained under aeration and used within 24 hours of collection.
- Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 2 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: The standard nutrient medium was composed of the following:
Solution 1:
KH2PO4: 8.5 g/L
K2HPO4: 21.75 g/L
Na2HPO4.2H2O: 33.3 g/L
NH4Cl: 1.7 g/L
Solution 2:
MgSO4.7H2O: 22.5 g/L
Solution 3:
CaCl2: 27.5 g/L
Solution 4:
FeCl3.6H2O: 0.25 g/L
1 mL of each of solutions 1-4 were added to each litre of aerated reverse osmosis purified and deionised water. The nutrient medium was left at room temperature (approximately 20 °C), under gentle agitation.
- Test temperature: 20 °C
- Continuous darkness: yes/no
SAMPLING
- Sampling frequency: Sufficient bottles were prepared in each test and control series to allow a single oxygen determination per bottle to be made at 0, 5, 15, and 28 days (duplicate bottles at each sampling time). Sufficient bottles for series (f) were prepared to provide information on inhibitory effects of days 0 and 28.
CONTROL AND BLANK SYSTEM
- Inoculum blank: Inoculated nutrient medium
- Toxicity control: 2 mg/L test substance plus filter paper and 3 mg/L sodium benzoate
STATISTICAL METHODS:
Theoretical Oxygen Demand (ThOD)
For a compound CcHhClclNnPpSsOoNana the theoretical oxygen demand may be calculated from:
ThOD(NO3) = 16([2c + ½(h-cl] + 5/2n + 5/2p + 3s + 1/2 na – o]/Molecular weight)
So for sodium benzoate. C6H5COONa. Mol. Wt. = 144
ThOD = 16([14 + 2.5 + 0.5 -2]/144) = 1.67 mgO2/mg
Estimated oxygen depletion for 3 mg/L = 5.01 mgO2/L
For ZK 24.942. C16H36Sn. Mol. Wt. = 347
ThOD = 16[32 + 18]/347 = 2.305 mgO2/mg
Estimated oxygen depletion for 2 mg/L = 4.61 mgO2/L
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
% Degradation
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 2
- Sampling time:
- 28 d
- Details on results:
- ZK 24.942 attained only 2 % biodegradation within 28 days and therefore cannot be termed readily biodegradable.
BOD5 / COD results
- Results with reference substance:
- Sodium benzoate attained 86 % biodegradation after 28 days.
Any other information on results incl. tables
Table 1: Dissolved oxygen measurements (mgO2/L)
Culture medium |
Day |
||||
0 |
5 |
15 |
28 |
||
a) Nutrient medium without inoculum
b) Nutrient medium with inoculum
c) Nutrient medium with inoculum
d) Test substance 2 mg/L plus filter paper
e) standard substance 3mg/L sodium benzoate
f) Test substance (2 mg/L) plus filter paper and sodium benzoate |
R1 R2 Mean R1 R2 Mean R1 R2 Mean R1 R2 Mean R1 R2 Mean R1 R2 Mean |
8.90 8.90 8.90 8.90 8.90 8.90 8.90 8.90 8.90 8.90 8.90 8.90 8.90 8.90 8.90 8.90 8.90 8.90 |
8.86 8.90 8.88 8.87 8.40 8.64 8.90 8.90 8.90 8.74 8.90 8.82 5.00 4.96 4.98 - - - |
8.74 8.78 8.76 8.68 8.60 8.64 8.74 8.65 8.70 8.60 8.66 8.63 5.11 4.43 4.77 - - - |
8.62 8.68 8.65 8.47 8.50 8.49 8.58 8.48 8.53 8.35 8.60 8.48 4.30 4.01 4.16 4.08 4.20 4.14 |
R1 & R2 Replicates 1 and 2
Table 2: Mean oxygen depletion and percent biodegradation values
Culture medium |
Day |
|||
5 |
15 |
28 |
||
a) Nutrient medium without inoculum |
} O2 depletion (mg O2/L) |
0.02 |
0.14 |
0.25 |
b) Nutrient medium with inoculum |
} O2 depletion (mg O2/L) |
0.26 |
0.26 |
0.41 |
c) Nutrient medium with inoculum |
} O2 depletion (mg O2/L) |
0 |
0.20 |
0.37 |
d) Test substance 2 mg/L plus filter paper |
} O2 depletion (mg O2/L) } % degradation |
0.08 2 |
0.07 2 |
0.05 1 |
e) standard substance 3mg/L sodium benzoate |
} O2 depletion (mg O2/L) } % degradation |
3.66 73 |
3.87 77 |
4.33 86 |
f) Test substance (2 mg/L) plus filter paper and sodium benzoate |
} O2depletion (mg O2/L) |
- |
- |
4.39 |
(ii) Test substance
Oxygen depletion = (a – d) – (a – c) from table 1
(ii) Standard substance (sodium benzoate)
Oxygen depletion = (a – e) – (a – b) from table 1
(iii) Inhibition check (test substance plus sodium benzoate)
Oxygen depletion = (a – f) – (a – c) from table 1
(iv) Inoculated and non-inoculated nutrient medium (plus filter paper blank)
Oxygen depletion = initial O2concentration – measured value
(v) % Degradation = (Oxygen depletion/Conc. of substance x ThOD NO3) x 100
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- ZK 24.942 attained 2 % biodegradation within 28 days and therefore may not be termed as readily biodegradable.
- Executive summary:
A study was performed to assess the ready biodegradability of ZK 24.942 in accordance with OECD Guideline for Testing of Chemicals No. 301D and EEC Methods for the Determination of Ecotoxicity, EEC Directive 67/548 Annex V Part C.6 (84/449/EEC), Closed Bottle Test. ZK 24.942 attained 2 % biodegradation within 28 days and therefore may not be termed as readily biodegradable. ZK 24.942 was not found to be inhibitory to activated sewage sludge bacteria under the conditions of this test.
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