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EC number: 212-449-1 | CAS number: 818-08-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 6, 2002 to January 15, 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- no
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): oxidation ditch in Hazerswoude, the Netherlands, on 3 December 2002
- Storage conditions: Transported in a plastic flask and aerated until use
- Storage length: 3 days
- Preparation of inoculum for exposure:
- Pretreatment:
- Concentration of sludge: solids in test flask = 100 mg (dw)/l
- Initial cell/biomass concentration:
- Water filtered: yes
- Type and size of filter used, if any: Whatman GF/C 0 47 mm - Duration of test (contact time):
- 28 d
- Initial conc.:
- 34.3 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Remarks:
- oxygen consumption due to the test or control substance at each time was calculated by subtracting the mean cumulative oxygen consumption in the blanks from that in the flask under consideration
- Details on study design:
- One mean concentration of 34.3 mg/l was tested, corresponding to a Theoretical Oxygen Demand (NH3) of 52.8 mg 02/l. An inoculum was prepared from activated sludge taken from an oxidation ditch used to treat domestic sewage (100 mg dw/l). There were 3 replicate flasks and oxygen concentration was determined every 5 hours. The inoculum activity control had a reference substance of 0 and 100 mg/L, 3 blank flasks and 2 replicates for the 100 mg/L control. The toxicity control reference substance was 100 mg/L in 2 replicate flasks. Oxygen concentration for the controls were determined every 5 hours.
- Reference substance:
- other: sodium acetate, anhydrous
- Preliminary study:
- Dibutyloxostannane was not biodegraded after 31 days. In this study, the 60% degradation criterion after 28 days was not met, and therefore the test substance was considered not readily biodegradable.
- Test performance:
- The test met the conditions of validity set forth by the OECD Guideline 301F and the EU Test Guideline C.4-D (similar to EPA Guideline OPPTS 835.3110).
- Parameter:
- % degradation (O2 consumption)
- Remarks:
- manometric respiration
- Value:
- 0
- Sampling time:
- 28 d
- Details on results:
- Table 2 shows the relevant mean Biochemical Oxygen Demand values and the percentage biodegradation of dibutyloxostannane at a concentration of 34.3 ± 3.9 mg/l, calculated from the ThOD NH3 (1.54 mg O2/mg) of the test substance.
The percentage of degradation of dibutyloxostannane after 28 days of incubation did not exceed 0% in a manometric respiration test at a concentration of 34.3 ± 3.9 mg/l, calculated from the ThOD NH3 (1.54 mg O2/mg) of the test substance. The biodegradation of dibutyloxostannane did not exceed the pass level of 60% THoD NH3 within 28 days, and therefore is classifed as "not readily biodegradeable". - Results with reference substance:
- The conditions of validity have been met as follows:
- The amount of oxygen consumed in the biodegradation test is so low, that this criteria has little relevance. However, the extreme replicate cumulative oxygen consumption values for the inoculum toxicity and activity control varied less than 20% at the end of the test.
- The reference substance was degraded 99% (ThOD) within 14 days.
- The degradation in the toxicity control was above 25% during the test.
- The oxygen consumption in the blanks with filter was 1.21-2.96 mg per flask after 28 days of incubation, which is equal to 4.0-9.9 mg/L, which is within the limits of validity.
- The pH remained within the valid range during the test in the blank and control tests. - Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- The percentage degradation of dibutyloxostannane after 28 days of incubation did not exceed 0% in a manometric respiration test at a mean test substance concentrations of 34 ± 3.9 mg/l calculated from the ThOD NH3 (1.54 mg O2/mg) of test substance. The biodegradation of dibutyloxostannane did not exceed the pass level of 60% ThOD NH3 within 28 days and, therefore, is classified as not readily biodegradeable. Dibutyloxostannane is not toxic to the inoculum, but a slight inhibitation of the degradation of the reference substance was observed.
- Executive summary:
The test medium was added directly to a glass fibre filter and the filter was placed in the mineral test medium. The concentration tested was 34.3 ± 3.9 mg/L, corresponding to a ThOD NH3 of 52.8 ± 6 mg O2/L. An inoculum was prepared from activated sludge taken from an oxidation ditch used to treat domestic sewage. The test met the conditions of validty given by the guidelines. The test material was not biodegraded after 31 days. The 60% degradation criterion after 28 days was not met and therefore the test substance was considered to be not readily biodegradable. Dibutyloxostannane is not toxic to the inoculum, but a slight inhibition of the degradation of the reference substance was observed.
Reference
Table 2. Biodegradation of dibutyloxostannane (34.3 ± 3.9 mg/L) | |||||
expressed as the BOD (mg O2/mg) and as percentage of its ThOD NH3 (mean values, n=3) | |||||
Time (days) | BOD (mg O2/mg) | % Biodegradation (ThODNH3) | |||
14 (336 hours) | 0 | -2 | |||
28 (680 hours) | 0 | -2 | |||
31 (755 hours) | 0 | -2 | |||
Description of key information
The following study is available to address the biodegradation in water endpoint:
Hanstveit, R. (2003). Dibutyloxostannane (Dibutyltin oxide, CAS No. 818-08-6): Determination of the ready biodegradability in a Manometric Respiration Test. Testing laboratory: TNO, Department of Biomolecular Sciences, Utrechtseweg 48, P. O. Box 360, 3700 AJ Zeist, The Netherlands. Report no.: V4016/01. Owner company: Organotin Environmental Programme (ORTEP) Association represented by Paramtrix Inc., 5808 Lake Washington Blvd. NE, Suite 200, Kirkland, WA 98033-7350. Study number: project no: 010.46080.01.08. Report date: 2003-09-24.
The study has been allocated a Klimisch score of 1 and is the key study for this endpoint.
Key value for chemical safety assessment
- Biodegradation in water:
- not biodegradable
- Type of water:
- freshwater
Additional information
The study Hanstveit R (2003) was included as the key study for this data requirement as it was performed to the OECD guideline 301 F and in compliance with GLP. The study was therefore assigned a reliability score of 1 and considered suitable for assessment. In a ready biodegradability study (OECD 301F) 0% biodegradation was observed after 28 days. DBTO is therefore defined as not readily biodegradable.
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