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EC number: 210-539-5 | CAS number: 617-94-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Justification for selection of skin irritation / corrosion endpoint:
WoE: No valid studies are available. All available data get a K4 since no original references are available only secondary references. The results from animals studies show mild to moderate irritation. There are two studies available with human volunteers. 4% does not result in skin irritation the neat substance applied to the skin under occlusion 24-48h give slight to irritating reactions in 14 out of 212 volunteers. Based on the responses observed severe effects on the skin are not expected. The lack of individual scores and the use of a non-standard technique preclude classification on the basis of EU or GHS criteria. A precautionary approach is chosen and the substance is classified: Irritant, Category 2
Justification for selection of eye irritation endpoint:
WoE: No valid studies are available. All available data get a K4 since no original references are available only secondary references.
The results from animal studies show irritation to the eyes. The lack of individual scores and the use of a non-standard technique preclude classification on the basis of EU or GHS criteria. A precautionary approach is chosen and the substance is classified: Irritant, Category 2
Effects on skin irritation/corrosion:irritating
Effects on eye irritation:irritating
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary references: WoE
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Remarks on result:
- other: see Any Other Information
- Interpretation of results:
- Category 2 (irritant)
- Remarks:
- Criteria used for interpretation of results: expert judgment
- Conclusions:
- No valid studies are available. All available data get a K4 since no original references are available only secondary references.
The results from animals studies show mild to moderate irritation. There are two studies available with human volunteers. 4% does not result in skin irritation the neat substance applied to the skin under occlusion 24-48h give slight to irritating reactions in 14 out of 212 volunteers. Based on the responses observed severe effects on the skin are not expected. The lack of individual scores and the use of a non-standard technique preclude classification on the basis of EU or GHS criteria. A precautionary approach is chosen and the substance is classified: Irritant, Category 2 - Executive summary:
No valid studies are available. All available data get a K4 since no original references are available only secondary references.
The results from animals studies show mild to moderate irritation. There are two studies available with human volunteers. 4% does not result in skin irritation the neat substance applied to the skin under occlusion 24-48h give slight to irritating reactions in 14 out of 212 volunteers. Based on the responses observed severe effects on the skin are not expected. The lack of individual scores and the use of a non-standard technique preclude classification on the basis of EU or GHS criteria. A precautionary approach is chosen and the substance is classified: Irritant, Category 2
Reference
Skin corrosion/ irritation |
WoE No valid studies are available. All available data get a K4 since no original references are available only secondary references. The results from animals studies show mild to moderate irritation. There are two studies available with human volunteers. 4% does not result in skin irritation the neat substance applied to the skin under occlusion 24-48h give slight to irritating reactions in 14 out of 212 volunteers. Based on the responses observed severe effects on the skin are not expected.The lack of individual scores and the use of a non-standard technique preclude classification on the basis of EU or GHS criteria. A precautionary approach is chosen and the substance is classified: Irritant, Category 2
Classification and Labeling Irritant, Category 2 |
3 (strong capillary injection,this is described as moderate irritation)
|
Union carbide corp. unpublished data. Cited in[Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 4687] |
In an acute dermal toxicity test three of four rabbits exhibited red and edematous skin and one exhibited hard and thick skin at 5 g/kg. Mild to moderate erythema and edema were seen at 2.5 and 1.25 g/kg |
RIFM (Research Institute for Fragrance Materials, Inc.), 1977. Acute Toxicity Study in Rats, Rabbits and Guinea Pigs. RIFM Report No. 1695, April 08. RIFM, Woodcliff Lake, NJ, USA. Cited in:Scognamiglio J,Jones L,Letizia CS,Api AM.Fragrance material review on 2-phenyl-2-propanol.Food Chem Toxicol.2012 Sep;50 Suppl 2:S130-3. |
Guinea Pig and Rabbit Skin: Daily application to the skin of rabbits and guinea pigs produced mild primary irritation. |
HERCULES INC; Technical Data Bulletin for Di-Cup (Dicumyl Peroxide) Including Toxicity Data for A-Methylstyrene, One of its Decomposition Products; 00/00/00; EPA No. 86-870001667; Fiche No. OTS0515743 |
In a pretest for a human maximization study, 4% in petrolatum was applied under occlusion to the backs of 25 healthy adult volunteers for 48 h. No subject exhibited any irritation |
RIFM (Research Institute for Fragrance Materials, Inc.), 1977. Report on Human Maximization Studies. RIFM Report No. 1702, June 06. RIFM, Woodcliff Lake, NJ, USA. Cited in:Scognamiglio J,Jones L,Letizia CS,Api AM.Fragrance material review on 2-phenyl-2-propanol.Food Chem Toxicol.2012 Sep;50 Suppl 2:S130-3. |
14 of 212 human volunteers had slight to irritating reactions when patch tested with neat substance. Occluded patches were applied for 24–48 h on the back or on the flexor aspect of the forearm |
Takenaka, T., Hasegawa, E., Takenaka, U., Saito, F., Odaka, T., 1968.Fundamental studies of safe compound perfumes for cosmetics. Part 1. The primary irritation of compound materials to the skin. ‘‘Preprint of Scientific Papers,’’ The Fifth Congress of International Federation of Societies of Cosmetic Chemists, May 12-17, Tokyo, pp. 313–329. Cited in:Scognamiglio J,Jones L,Letizia CS,Api AM.Fragrance material review on 2-phenyl-2-propanol.Food Chem Toxicol.2012 Sep;50 Suppl 2:S130-3. |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Principles of method if other than guideline:
- no data
- GLP compliance:
- no
- Remarks on result:
- other: see Any Other Information
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Remarks:
- Criteria used for interpretation of results: expert judgment
- Conclusions:
- No valid studies are available. All available data get a K4 since no original references are available only secondary references.
The results from animal studies show irritation to the eyes. The lack of individual scores and the use of a non-standard technique preclude classification on the basis of EU or GHS criteria. A precautionary approach is chosen and the substance is classified: Irritant, Category 2 - Executive summary:
No valid studies are available. All available data get a K4 since no original references are available only secondary references.
The results from animal studies show irritation to the eyes. The lack of individual scores and the use of a non-standard technique preclude classification on the basis of EU or GHS criteria. A precautionary approach is chosen and the substance is classified: Irritant, Category 2
Reference
Eye corrosion/ irritation |
WoE No valid studies are available. All available data get a K4 since no original references are available only secondary references. The results from animal studies show irritation to the eyes.The lack of individual scores and the use of a non-standard technique preclude classification on the basis of EU or GHS criteria. A precautionary approach is chosen and the substance is classified: Irritant, Category 2
Classification and Labeling Irritant, Category 2 |
5 (Scale of 1 - 10; 1 = no observed reaction; 10 = most severe) |
Union carbide corp. unpublished data. Cited in[Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 4687] |
Application of 0.1 ml to the eyes of rabbits and 0.05 ml to the eyes of guinea pigs daily for 15 days produced some irritation with erythema. There was complete recoverywithin 7-14 days, with no permanent corneal damage. |
HERCULES INC; Technical Data Bulletin for Di-Cup (Dicumyl Peroxide) Including Toxicity Data for A-Methylstyrene, One of its Decomposition Products; 00/00/00; EPA No. 86-870001667; Fiche No. OTS0515743 |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Justification for classification or non-classification
Skin: No valid studies are available. All available data get a K4 since no original references are available only secondary references. The results from animals studies show mild to moderate irritation. There are two studies available with human volunteers. 4% does not result in skin irritation the neat substance applied to the skin under occlusion 24-48h give slight to irritating reactions in 14 out of 212 volunteers. Based on the responses observed severe effects on the skin are not expected. The lack of individual scores and the use of a non-standard technique preclude classification on the basis of EU or GHS criteria. A precautionary approach is chosen and the substance is classified: Irritant, Category 2
Eye: No valid studies are available. All available data get a K4 since no original references are available only secondary references. The results from animal studies show irritation to the eyes. The lack of individual scores and the use of a non-standard technique preclude classification on the basis of EU or GHS criteria. A precautionary approach is chosen and the substance is classified: Irritant, Category 2
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