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Diss Factsheets
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EC number: 204-198-1 | CAS number: 117-57-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- The sutdy was not performed according to GLP. No monitoring analysis was performed.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-hydroxy-2-methylquinoline-4-carboxylic acid
- EC Number:
- 204-198-1
- EC Name:
- 3-hydroxy-2-methylquinoline-4-carboxylic acid
- Cas Number:
- 117-57-7
- Molecular formula:
- C11H9NO3
- IUPAC Name:
- 3-hydroxy-2-methylquinoline-4-carboxylic acid
- Test material form:
- solid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- yes
- Remarks:
- Chromophor was used as a vehicle in a concentration of 100 mg/L in the stock solution containing 500 mg/L test substance. By dilution of the stock solutions also the vehicle was diluted accordingly.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Source: Institut National de Recherche Chimique Appliquee, France
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Remarks on exposure duration:
- Effects were recorded after 3, 6, 24 and 48h of exposure
Test conditions
- Hardness:
- 2.7 mMol/L
- Test temperature:
- 19-21°C
- pH:
- 8.8
- Dissolved oxygen:
- >2 mg/L
- Salinity:
- artificial drinking water
- Conductivity:
- 600-700 µS/cm
- Nominal and measured concentrations:
- nominal
- Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 250 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 250 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- Mortality was only observed in the highest test concentration of 500 mg/L. However the author reports that in concentration >125 mg/L the substance precipitated partially. Especially in the 500 mg/L test solution daphnia were adsorbed to particles. Therefore it cannot be excluded that the effects in this concentration were physical effects.
Any other information on results incl. tables
The table shows the number of mobile daphnia after 48h:
concentration | vessel 1 | vessel 2 | vessel 3 | vessel 4 | |
control | 5 | 5 | 5 | 5 | |
solvent control | 5 | 5 | 5 | 5 | |
500 mg/L | 1 | 0 | 0 | 0 | |
250 mg/L | 5 | 5 | 5 | 5 | |
125 mg/L | 5 | 5 | 5 | 5 | |
62.5 mg/L | 5 | 5 | 5 | 5 | |
31.25 mg/L | 5 | 5 | 5 | 5 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- No effects to daphnia are observed up to the limit of the water solubility.
- Executive summary:
In a test according to EU methode C.2 with daphnia magna, immobilisation was only observed in the highest test concentration of 500 mg/L. It is however questionable whether the observations are due to physical effects as the substance was partially precipitated and daphnia were found adsorbed to particles. The EC50 was therefore defined as >250 mg/L. As a conclusion, no effects up to the limit of the water solubility were observed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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