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Diss Factsheets
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EC number: 203-943-8 | CAS number: 112-18-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Reliable screening studies on biodegradation are available for eight out of ten DMA category members. These altogether 15 studies (4x RL 1, 11x RL 2) were performed according to OECD 301 guidelines and consistently demonstrated ready biodegradability of DMA.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
A pass-level criterion for most OECD 301-tests is the 10-day window requirement. For some of the studies summarized below this was not met. However, as all of the DMA category members consist of mixtures of substances with varying hydrocarbon chain lengths, the 10-d window isgenerally notapplicable for these substances.
Key studies for DMA category members C10, C12, C12-14, C14 and C12-18 DMA were performed according to OECD 301B (CO2-Evolution). Degradation levels between 67% (C12-14 DMA) and 93% (C12-18 DMA) were achieved within 28 days and thus for all of them the pass level for ready biodegradability is met. Several supporting studies performed according to OECD 301-guidelines are available corroborating these results (inherent biodegradability test for C14-DMA, ready biodegradability test for the other four compounds).
Key studies for DMA category members C16, C16-18, and C18 DMA were performed according to OECD 301D (Closed bottle test). Degradation levels within 28 days were 60% for C16 DMA and 68% for C18 DMA, again demonstrating ready biodegradability. In the closed bottle test with C16-18 DMA 58% degradation were achieved within 28 days and 66% within 42 days. For this compound an additional reliable (with restrictions) mechanistic (supporting) study is available, demonstrating ready biodegradability using a variety of inocula, namely activated sludge, river water, ditch water and soil. Furthermore, in this study mechanistic aspects of degradation were elucidated using isolated bacterial strains corroborating biodegradability for the category in general. Supporting studies are also available for C16 and C18 showing ready and inherent biodegradability, respectively.
In conclusion, from the broad experimental database it can be concluded with that DMA category members are readily biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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