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EC number: 202-424-3 | CAS number: 95-49-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Uniformly ring-labeled 14C o-chlorotoluene was administered by gavage to rats at a dose of 320 mg/kg bw. Expired air, urine and faeces were examined for metabolites.
The recovery of radioactivity at 48 h averaged 11% in the expired air, 81% in urine, and 4% in feces; radioactivity in expired air was identified as unchanged o-chlorotoluene; urinary metabolites (as % of dose) were: o-chlorohippuric acid (16- 20%), a mercapturic acid conjugate of o-chlorotoluene (20- 24%) and polar metabolites (36-43%); enzymatic hydrolysis of rat urine indicated that the polar metabolites included the glucuronide conjugate of the phenolic hydroxylation product of o-chlorotoluene; unchanged o-chlorotoluene was not present in urine or feces of treated rats.
When male and female Sprague-Dawley rats were given a single oral dose of o-chlorotoluene at 1 mg/kg bw by gavage, 85 - 92% of the applied dose was eliminated in urine, 5 - 8% was excreted in feces and 1 - 4% of the applied dose was exhaled as volatile 14C; at least 84% of the volatile 14C was identified as unmetabolized o-chlorotoluene whereas 14C-carbon dioxide was an insignificant metabolite (< 1% applied dose).
A similar distribution of radioactivity was also seen in female rats given single oral doses of 91 or 102 mg/kg bw. The major urinary and fecal metabolites were o-chlorohippurate, a beta-glucuronide of o-chlorobenzyl alcohol and mercapturic acid; no significant sex-related metabolic differences were noticed between males and females and the same qualitative and quantitative distribution of metabolites was found for doses of 1-102 mg/kg bw.
O-chlorotoluene is quickly absorbed from the gastrointestinal tract into blood as evidenced by exhalation of o-chlorotoluene and the rapid peak in 14C residues at ca. 2 h in blood plasma. Analysis of the 14C residues in plasma showed that the two major radioactive components were mercapturic acid and the beta-glucuronide of o-chlorobenzyl alcohol (38 and 25% of plasma 14C, respectively), while trace levels of o-chlorotoluene, o-chlorobenzoic acid, o-chlorobenzyl alcohol and o-chlorohippurate were detectable also; virtually all of the administered o-chlorotoluene was eliminated within 4 d with < 1% remaining in the carcass.
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