Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-075-4 | CAS number: 78-00-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
Several studies are used as a weight of evidence approach to indicate that TEL distributes quickly through the body rapidly converting enzymically by the liver to TriEL and inorganic lead and causes damage to all major organs, in particular the liver, kidney and brain.
TEL is highly volatile and readily dissolvable in lipids. It is therefore easily inhaled and rapidly absorbed through the skin. Its elimination through faeces and urine is slow. It is metabolised in the liver to triethyllead (TriEL). TEL reaches its highest concentration in the liver followed by the kidney and brain affecting both central nervous and peripheral transmitters, myelin synthesis and metabolism.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
TEL is highly volatile and is therefore easily inhaled. It is readily dissolvable in lipids. and rapidly absorbed through the skin (Kehoe 1976). Its elimination through faeces and urine is slow. It is metabolised in the liver to triethyllead (TriEL). TEL reaches its highest concentration in the liver followed by the kidney and brain affecting both central nervous and peripheral transmitters, myelin synthesis and metabolism. (Arai et al 1983)
After absorption, TEL is distributed rapidly in the blood through the body. The half life in the blood is 13 seconds. The maximum concentration is reached in the blood and liver after 1 -3 hours. In the kidney about 11% of the exposure dose accumulates within 20 hours. After i.p administration, maximium tissue levels in the whole animal of TEL in the form of TriEL were measured after 5 days in rats (Hayakawa 1972a).
After intravenous administration of TEL , inorganic lead is almost the only excreted product present in the faeces. More than 2/3 of the dose is eliminated this way with the balance in urine. After 24 hours, 12% of the total lead is present in faeces; 90% in the form of inorganic lead (Arai et al 1983).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.