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Diss Factsheets
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EC number: 200-090-3 | CAS number: 51-34-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1995-03-10 to 1995-03-22
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Justification for type of information:
- The read-across justification is included as an attachment to Iuclid section 13.
- Qualifier:
- according to guideline
- Guideline:
- other: DIN 38412 L31
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- GLP compliance:
- not specified
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- Leuciscus idus
- Details on test organisms:
- TEST ORGANISM
- Common name: Gold orfe (Leuciscus idus)
- Source: Fischzucht Eggers, Postfach 12, 24594 Hohenstedt, Germany
- Length at study initiation (length definition, mean, range and SD): 5-8 cm
- Feeding during test: no
ACCLIMATION
- Acclimation period: one week quaratine
- Acclimation conditions (same as test or not): not
- Feeding frequency: daily - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- Sum of Ca and Mg ions: 2.5 mmol/L
- Test temperature:
- 20+-1°C
- pH:
- 6.8 to 7.2
- Dissolved oxygen:
- 8.3 to 8.6 mg O2/L
- Salinity:
- not applicable
- Nominal and measured concentrations:
- 0, 2, 3, 4, 5, 6 g/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: all glass aquarium (30 L)
- Water volume per vessel: 10 L
- Aeration: min. 80% from saturation value
- No. of organisms per vessel: 3 fish per concentration
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Day-Light-Cyclus: 16 h:8 h
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: test medium was prepared from reagent grade salts (Ca, Mg, Na, K) and demineralized water- Ca/Mg ratio: 4:1- Conductivity: 0.5 µS/cm - Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 2 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: no- Observations on body length and weight: 6.5 to 7.3 cm; 2.2 to 3.1 g- Mortality of control: no
- Sublethal observations / clinical signs:
Cumulative mortality
Nominal concentration (g/L) 24 h 48 h control 0 0 2 0 0 3 2 2 4 0 1 5 2 2 6 2 2 - Validity criteria fulfilled:
- yes
- Conclusions:
- The toxicological concentration limit for buscopan is 2 g/L at 20°C under the conditions of the test. In consequence, the NOEC is 2 g/L.
Reference
Description of key information
A 48-hour NOEC of 2 g/L was determined for the effects of the read-across substance Hyoscine butylbromide on mortality for fish according to an reliable study. No LC50 was determined in this study, the LC50 will be defined to be >2 g/L.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.