Summary of Classification and Labelling
Harmonised classification - Annex VI of Regulation (EC) No 1272/2008 (CLP Regulation)
General Information
Index Number EC / List no.

EC: European Community number/ List no.: List number assigned by ECHA.

List Numbers are purely technical identifiers for processing a submission via REACH-IT. More information: https://echa.europa.eu/information-on-chemicals/registered-substances/information

CAS Number International Chemical Identification
606-021-00-7 212-828-1 872-50-4 N-methyl-2-pyrrolidone
1-methyl-2-pyrrolidone

ATP Inserted / Updated: CLP00/ATP09 This field indicates when an entry in Annex VI to CLP has been inserted and/or updated with an Adaptation to Technical Progress (ATP) to the CLP Regulation.
CLP Classification (Table 3)
Classification Labelling Specific Concentration limits, M-Factors, Acute Toxicity Estimates (ATE) Notes
Hazard Class and Category Code(s) Hazard Statement Code(s) Hazard Statement Code(s) Supplementary Hazard Statement Code(s) Pictograms, Signal Word Code(s)
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
STOT SE 3; H335: C ≥ 10 %
Eye Irrit. 2 H319 H319
STOT SE 3 H335 H335
Repr. 1B H360D *** H360D ***

Signal Words Pictograms
Danger
GHS08
Health hazard
GHS07
Exclamation mark
Seveso III Data
Disclaimer: Please note that some of the substances covered by the Seveso Directive can belong to more than one Seveso categories. It will be up to the users to decide whether their substance or mixture fall in one or in more of these classification categories depending on the tonnage bands and the concentrations.
Please also note that ECHA is not an authority for the Seveso Directive and that the Seveso categorisation below is provided for information only. The Seveso III Directive (Directive 2012/18/EU repealing Directive 96/82/EC (Seveso II) from 1 June 2015) is the only authentic legal reference and that the information in this inventory does not constitute legal advice. For further information on Seveso, please ask your national authority.

Seveso Data
Seveso Substance Seveso Categories
Nie
Notified classification and labelling
General Information
EC / List no.

EC: European Community number/ List no.: List number assigned by ECHA.

List Numbers are purely technical identifiers for processing a submission via REACH-IT. More information: https://echa.europa.eu/information-on-chemicals/registered-substances/information

Name CAS Number
The CAS number associated with this substance in the EC Inventory and/or REACH-IT is reported here. In some cases, e.g. for differently hydrated forms of the same substance, alternative CAS numbers have been notified. In those cases, the additional CAS numbers are published in the column “additional notified information” below.
212-828-1 1-methyl-2-pyrrolidone 872-50-4

Notified classification and labelling according to CLP criteria
Classification Labelling Specific Concentration limits, M-Factors Notes Classification affected by Impurities / Additives

This check appears when a notifier has indicated that an impurity or an additive present in the substance impacts the notified classification. ECHA cannot reveal the identity of the impurity/additive or determine the exact impact it has on the classification.

Additional Notified Information

State/form: The notified state/form of the substance for all notifications classifying in this manner is reported under this link. Additional CAS number(s): Occasionally, a notification contains a different CAS number than the one reported under the general information section above. In those cases, all different notified CAS numbers associated with the aggregated classification are reported under this link. IUPAC name(s): Publicly available IUPAC names from all notifications classifying in this manner are reported under this link.

Number of Notifiers

This number indicates how many companies notified this classification. All members of a REACH registration joint submission and all participants in a group of manufacturers/importers who notified are counted. The grouping is done automatically with no manual verification.

Joint Entries

This check appears when a classification comes from a lead dossier of a REACH registration joint submission. When a member submits a classification separately under Article 11(3) of REACH (opt-out), this classification is displayed separately and not marked as a joint entry.

Hazard Class and Category Code(s) Hazard Statement Code(s) Hazard Statement Code(s) Supplementary Hazard Statement Code(s) Pictograms, Signal Word Code(s)
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
STOT SE 3; : C ≥ 10 %
State/Form
46 yes View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (nose) H335
Repr. 1B H360 (developmental e...) H360 (unborn child)
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Repr. 1B; : C ≥ 5 %
State/Form
IUPAC Names
846 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 H335
Repr. 1B H360 (D) H360 (D)
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Repr. 1B; : C ≥ 5 %
STOT SE 3; : C ≥ 10 %
State/Form
IUPAC Names
553 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 H335
Repr. 1B H360 (D) H360 (D)
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
STOT SE 3; : C ≥ 10 %
State/Form
IUPAC Names
83 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 H335
Repr. 1B H360 (D) H360
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Repr. 1B; : C ≥ 5 %
STOT SE 3; : C ≥ 10 %
State/Form
IUPAC Names
66 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (not available) H335
Repr. 1B H360 (unborn child) H360
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
IUPAC Names 57 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (Respiratory sys...) H335
Repr. 1B H360 H360
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
STOT SE 3; : C ≥ 10 %
Repr. 1B; : C ≥ 5 %
State/Form
IUPAC Names
50 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 H335
Repr. 1B H360 (D) H360
Skin Irrit. 2 H315 H315 GHS08
Dgr
STOT SE 3; : C ≥ 10 %
IUPAC Names 48 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (Not provided) H335
Repr. 1B H360 H360
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
IUPAC Names 46 View details
  H318
Eye Irrit. 2 H319  
STOT SE 3 H335 (not specified) H335
Repr. 1B H360 H360
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
State/Form
IUPAC Names
45 View details
Eye Irrit. 2 H319 H319
Repr. 1B H360 H360
STOT SE 3 H370 (unknown) H370
Skin Irrit. 2 H315 H315 GHS07
Wng
State/Form
IUPAC Names
35 View details
Eye Irrit. 2 H319 H319
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
STOT SE 3; : C ≥ 10 %
Repr. 1B; : C ≥ 5 %
State/Form
IUPAC Names
31 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (not specified) H335
Repr. 1B H360  
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
30 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (Not available) H335
Repr. 1B H360 (Unborn child) H360
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
State/Form
IUPAC Names
22 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (Affected Organs) H335
Repr. 1B H360 (D) H360 (D)
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Repr. 1B; : C ≥ 5 %
STOT SE 3; : C ≥ 5 %
State/Form
IUPAC Names
18 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (Lung) (Inhalation) H335
Repr. 1B H360 H360
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Repr. 1B; : C ≥ 5 %
STOT SE 3; : C ≥ 10 %
17 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (Blood, kidneys,...) H335
Repr. 1B H360 H360
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
15 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (RTI) H335
Repr. 1A H360 H360
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
State/Form
13 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (No data) (Oral) H335
Repr. 1B H360 H360
Skin Irrit. 2 H315 H315 GHS08
Dgr
STOT SE 3; : C ≥ 10 %
IUPAC Names 12 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 H335
Repr. 1B H360 H360
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
IUPAC Names 10 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (respiratory sys...) H335
Repr. 1B H360 H360
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Repr. 1B; : C ≥ 5 %
State/Form
IUPAC Names
8 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (respiratory tra...) H335
Repr. 1B H360 (H360D) H360
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
STOT SE 3; : 10 % ≤ C ≤ 100 %
Repr. 1B; : 5 % ≤ C ≤ 100 %
yes State/Form
IUPAC Names
7 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (respiratory tra...) H335
Repr. 1B H360 H360
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
State/Form
7 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (Respiratory sys...) H335
Repr. 1B H360 (Oral) (May damage the ...) H360
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
STOT SE 3; : C ≥ 10 %
Repr. 1B; : C ≥ 5 %
7 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (Respiratory tra...) H335
Repr. 1B H360 H360
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
State/Form
IUPAC Names
6 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (not identified) H335
Repr. 1B H360 H360
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Repr. 1B; : C ≥ 5 %
State/Form
6 View details
Eye Irrit. 2 H319 H319
  H335
Repr. 1B H360 (H360D May damag...)  
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
IUPAC Names 6 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (respiratory org...) H335
Repr. 1B H360 H360
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Repr. 1B; : 5 % ≤ C < 100 %
5 View details
Eye Irrit. 2 H319 H319
Repr. 1B H360 (May damage the ...) H360 (May damage the ...)
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
4 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (Respiratory tra...) H335
Repr. 1B H360 H360 (D)
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
4 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (data lacking) H335
Repr. 1B H360 H360
Skin Irrit. 2 H315 H315 GHS08
Dgr
State/Form
IUPAC Names
4 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (organs) H335
Repr. 1B H360 H360
Skin Irrit. 2 H315 H315 (H315) GHS08
GHS07
Dgr
IUPAC Names 4 View details
Eye Irrit. 2 H319 H319 (H319)
STOT SE 3 H335 (respiratory sys...) H335 (H335)
Repr. 1B H360 (May damage the ...) H360 (May damage the ...)
Skin Irrit. 2 H315 H315 GHS08
Wng
IUPAC Names 3 View details
Eye Irrit. 2 H319 H319
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Repr. 1B; : 5 % ≤ C < 100 %
STOT SE 3; : 10 % ≤ C < 100 %
3 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (Not applicable) H335
Repr. 1B H360 (May damage the ...) H360 (May damage the ...)
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
State/Form
3 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (lung) (Inhalation) H335
Repr. 1A H360 H360
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
State/Form
IUPAC Names
2 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (Not determined) H335
Repr. 1A H360 (H360D: May dama...) H360
Skin Irrit. 2 H315 H315 (H319: Causes se...) GHS07
Wng
IUPAC Names 2 View details
Eye Irrit. 2 H319  
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
State/Form
2 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (Lung) H335
Repr. 1B H360 H360
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
State/Form
IUPAC Names
1 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (ucous membranes...) (oral and dermal) H335
Repr. 1B H360 (Dermal) H360
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
State/Form
IUPAC Names
1 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (Not provided) H335
Repr. 1B H360 H360
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
STOT SE 3; : C ≥ 10 %
Repr. 1B; : C ≥ 5 %
State/Form
IUPAC Names
1 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (not available) H335
Repr. 1B H360 H360
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
1 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (Inhalation) H335
Repr. 1B H360 H360
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Repr. 1B; : C ≥ 5 %
STOT SE 3; : C ≥ 10 %
State/Form
1 View details
Eye Irrit. 2A H319 H319
STOT SE 3 H335 (No information ...) H335
Repr. 1B H360 (May damage the ...) H360
Skin Irrit. 2 H315   Dgr
IUPAC Names 1 View details
Eye Irrit. 2 H319  
STOT SE 3 H335 (not known)  
Repr. 1B H360  
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Repr. 1B; : C ≥ 5 %
STOT SE 3; : C ≥ 10 %
State/Form
IUPAC Names
1 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (unknown) H335
Repr. 1B H360 (unknown) H360 (May damage fert...)
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
STOT SE 3; : C ≥ 10 %
Repr. 1B; : C ≥ 5 %
State/Form
1 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (respiratory) (Inhalation) H335
Repr. 1B H360 H360
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
State/Form
IUPAC Names
1 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (respiratoty tra...) (Inhalation) H335
Repr. 1B H360 (Oral) (developmental) H360 (developmental -...)
Not Classified               1  
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
State/Form
1 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (Respiratory tra...) H335
Repr. 1B H360 H360
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
State/Form
1 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (AFFECTED ORGANS) H335
Repr. 1B H360 H360
Skin Irrit. 2 H315 H315 GHS07
Wng
State/Form
1 View details
Eye Irrit. 2 H319 H319
Acute Tox. 4 H332 H332
  H335
Skin Irrit. 2 H315 H315 GHS08
GHS05
GHS07
Wng
1 View details
Eye Dam. 1 H318 H318
STOT SE 3 H335 (lung) H335
STOT RE 1 H372 (lung) H372
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Repr. 1B; : C ≥ 5 %
State/Form
1 View details
Eye Irrit. 2 H319 H319
  H335
Repr. 1A H360 (H360D May damag...)  
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Repr. 1B; : 5 % < C ≤ 100 %
STOT SE 3; : 10 % < C ≤ 100 %
State/Form
IUPAC Names
1 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (lung) H335
Repr. 1B H360 H360
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Repr. 1B; : C ≥ 5 %
State/Form
IUPAC Names
1 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (Inhalation) H335
Repr. 1B H360 (D) H360 (D)
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
State/Form
1 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (Respiratory org...) H335
Repr. 1B H360 (Oral) (May damage the ...) H360
Skin Irrit. 2 H315 H315 GHS08
GHS07
Wng
State/Form
1 View details
Eye Irrit. 2 H319 H319
Repr. 2 H361 (Oral) H361
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
STOT SE 3; : C ≥ 10 %
Repr. 1B; : C ≥ 5 %
State/Form
IUPAC Names
1 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (Respiratory tra...) (Inhalation) H335
Repr. 1B H360 H360
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Repr. 1B; : C ≥ 5 %
1 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (respiratory tra...) H335
Repr. 1B H360 H360
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
Repr. 1B; : C ≥ 5 %
STOT SE 3; : C ≥ 10 %
State/Form
IUPAC Names
1 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (nose) (Inhalation) H335
Repr. 1B H360 (Oral) (development) H360 (D)
Skin Irrit. 2 H315 H315 GHS08
GHS07
Dgr
State/Form
IUPAC Names
1 View details
Eye Irrit. 2 H319 H319
STOT SE 3 H335 (Respiratory sys...) (oral and inhala...) H335
Repr. 1B H360 (oral and inhala...) ((Unborn child)) H360

Number of Aggregated Notifications: 61