Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
402-860-6
CAS no.:
110553-27-0
Index number:
Molecular formula:
C25H44OS2
SMILES:
CCCCCCCCSCC1=CC(CSCCCCCCCC)=C(O)C(C)=C1
InChI:
InChI=1S/C25H44OS2/c1-4-6-8-10-12-14-16-27-20-23-18-22(3)25(26)24(19-23)21-28-17-15-13-11-9-7-5-2/h18-19,26H,4-17,20-21H2,1-3H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
8
Of which contain:
1 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
ELINCS (European LIst of Notified Chemical Substances) List

Hazard classification & labelling

According to the notifications provided by companies to ECHA in REACH registrations no hazards have been classified.
According to the majority of notifications provided by companies to ECHA in CLP notifications no hazards have been classified.

Breakdown of all 120 C&L notifications submitted to ECHA

Not Classified
Aquatic Chronic 4 H413
Skin Sens. 1 H317
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 10 active registrations under REACH, 1 Joint Submission(s) and 5 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 1 000+ tonnes per year.

This substance is used in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

This substance is used in the following activities or processes at workplace: production of mixtures or articles by tabletting, compression, extrusion or pelletisation, the low energy manipulation of substances bound in materials or articles, high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding) and calendering operations.

Release to the environment of this substance can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal). Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance can be found in products with material based on: rubber (e.g. tyres, shoes, toys).

This substance is used in the following products: coating products, inks and toners and polymers.

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: plastic products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes, transfer of substance into small containers, calendering operations and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Other release to the environment of this substance is likely to occur from: indoor use.

This substance is used in the following products: polymers.

This substance is used in the following activities or processes at workplace: transfer of chemicals at dedicated facilities, transfer of substance into small containers, production of mixtures or articles by tabletting, compression, extrusion or pelletisation, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes, closed, continuous processes with occasional controlled exposure and closed batch processing in synthesis or formulation.

Release to the environment of this substance can occur from industrial use: formulation in materials, formulation of mixtures and in the production of articles.

This substance is used in the following products: polymers, coating products and inks and toners.

This substance is used for the manufacture of: plastic products.

This substance is used in the following activities or processes at workplace: production of mixtures or articles by tabletting, compression, extrusion or pelletisation, batch processing in synthesis or formulation with opportunity for exposure, transfer of chemicals, treatment of articles by dipping and pouring, mixing in open batch processes, transfer of substance into small containers, calendering operations and roller or brushing applications.

Release to the environment of this substance can occur from industrial use: in the production of articles.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation and transfer of chemicals at dedicated facilities.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • BASF Italia S.p.A., Via Marconato 8 20811 Cesano Maderno Italy
  • Chemservice S.A. (8LF5), 5, an de Laengten 6776 Grevenmacher Luxembourg
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • Rianlon, Heinrich Collinstr 17 2232 Deutsch Wagram Austria
  • SI Group DEAB (Imp), Teplitzer Strasse 84478 Waldkraiburg Germany
  • Synthos Dwory 7 spółka z ograniczoną odpowiedzialnością spółka jawna, ul. Chemików 1 32-600 Oświęcim Poland
  • TÜV SÜD Iberia, S.A.U. (068), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany

Substance names and other identifiers

4,6-bis(octylthiomethyl)-o-cresol
EC Inventory, REACH pre-registration
Phenol, 2-methyl-4,6-bis[(octylthio)methyl]-
Other
2-Methyl-4,6-bis(octylsulfanylmethyl)phenol
C&L Inventory, Registration dossier
2-methyl-4,6-bis[(octylsulfanyl)methyl]phenol
Other
Kumanox-3020
Registration dossier
THANOX 1520
Registration dossier
ATLEN 1520
Registration dossier
Irganox 1520
Registration dossier
Irganox 1520 L
Registration dossier
Irganox 520
Registration dossier
Irgastab Cable KV 10
Registration dossier
K-NOX 1520
Registration dossier
SONGNOX 1520
Registration dossier
SONGNOX 1520 LQ
Registration dossier
Synonym: TK 12229
Registration dossier
110553-27-0
CAS number
C&L Inventory, Registration dossier, Other
1456711-41-3
Deleted CAS number
Other
168255-63-8
Deleted CAS number
Other
224778-45-4
Deleted CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 7 studies submitted
  • 3 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (67%), Solid (33%) [3]
C Form
Not specified (100%) [1]
C Odour
Faint (100%) [2]
C Substance type
Organic (100%) [3]

Type of Study provided
Studies with data
Key study 3 1
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 6 studies submitted
  • 4 studies processed
R Melting / freezing point
14 - 14.15 °C [4]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Melting / freezing point at 101 325 Pa
14 °C

Boiling point

Study results
  • 6 studies submitted
  • 4 studies processed
R Boiling point
178 °C @ 11 - 101 300 Pa [4]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Boiling point at 101 325 Pa
178 °C

Density

Study results
  • 7 studies submitted
  • 6 studies processed
R Bulk density
0.976 g/cm³ @ 20 °C [1]
R Density
0.976 - 0.981 g/cm³ @ 20 °C [3]
R Relative density
0.972 - 0.997 @ 20 °C [4]

Type of Study provided
Studies with data
Key study 6
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Relative density at 20°C
0.981 - 976.1

Vapour pressure

Study results
  • 7 studies submitted
  • 5 studies processed
R Vapour pressure
0 - 1 Pa @ 20 - 100 °C [6]

Type of Study provided
Studies with data
Key study 6
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Vapour pressure
1 Pa @ 25 °C

Partition coefficient

Study results
  • 8 studies submitted
  • 5 studies processed
R Log Pow
10 - 10.5 @ 20 °C and pH 7 [5]

Type of Study provided
Studies with data
Key study 3 3
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Log Kow (Log Pow)
10 @ 20 °C

Water solubility

Study results
  • 7 studies submitted
  • 4 studies processed
R Water solubility (mass/vol.)
20 - 2 000 µg/L @ 20 °C and pH 5.5 - 7.5 [4]

Type of Study provided
Studies with data
Key study 5
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Water solubility
99 - 2 000 µg/L @ 20 - 25 °C

Solubility in organic solvents / fat solubility

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Surface tension

Study results
  • 6 studies submitted
  • 3 studies processed
R Surface tension
419 mN/m @ 20 - 10 000 µg/L and 20 °C [3]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Surface tension at 20 °C
419 mN/m @ 10 mg/L

Flash point

Study results
  • 6 studies submitted
  • 4 studies processed
R Flash point
200 °C [4]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 1 summary processed
Flash point at 101 325 Pa
200 °C

Auto flammability

Study results
  • 6 studies submitted
  • 4 studies processed
R Autoflammability / self-ignition
330 °C @ 97.7 - 101.325 kPa [4]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Autoflammability / self-ignition at 101 325 Pa
330 °C

Flammability

Study results
  • 8 studies submitted
  • 1 study processed
C Interpretation of results
Non flammable (100%) [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 6
Exposure cons.
Other 1
C Summaries
  • 2 summaries submitted
  • 1 summary processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 7 studies submitted
  • 3 studies processed
C Interpretation of results
Non-explosive (100%) [3]

Type of Study provided
Studies with data
Key study 5
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other 2
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 5 studies submitted
  • 2 studies processed
C Dissociating properties
Yes (50%), No (50%) [2]
R Dissociation constant
9.44 - 10.65 @ 20 °C [2]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 2 summaries submitted
  • 1 summary processed
pKa at 20 °C
10.65

Viscosity

Study results
  • 4 studies submitted
  • 3 studies processed
R dynamic viscosity (in mPa s)
33 - 87 [5]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Dynamic viscosity at 20 °C
33 - 87 mPa.s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 2 studies submitted
  • 2 studies processed
R Dissipation half life (DT50)
3.36 - 5.07 h [2]
R Degradation rate constant (OH radicals)
6.394 cm³ molecule-1 d-1 [1]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Half life in air
3.36 h
Degradation rate constant with OH radicals
6.394 cm³ molecule-1 d-1

Hydrolysis

Study results
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 9 studies submitted
  • 3 studies processed
C Interpretation of results
Under test conditions no biodegradation observed (100%) [3]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence 1
Other 1 2
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 1 summary processed
Biodegradation in water
Inherently biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - L/kg ww
26.127 L/kg ww

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Koc at 20°C
99

Henrys law constant (H)

Study results
  • 2 studies submitted
  • 2 studies processed
R H - (pressure) m³/mol
0 - 0.001 Pa m³/mol @ 25 °C and 1 Pa [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Henry's law constant
0 Pa.m³.mol-1 @ 25 °C

Distribution modelling

Study results
  • 1 study submitted
  • 1 study processed
% Distribution in Media:
R Air 0.049 % [1]
R Water 11.4 % [1]
R Soil 62.8 % [1]
R Sediment 25.8 % [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 4 summaries submitted
  • 4 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 100 - 100 000 ng/L (2)
Intermittent releases (freshwater) 1 - 1 000 µg/L (2)
Marine water 10 - 10 000 ng/L (2)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 1 mg/L (2)
Sediment (freshwater) 252 - 8 270 µg/kg sediment dw (2)
Sediment (marine water) 25.2 - 827 µg/kg sediment dw (2)
Hazard for Air
Air -
Hazard for Terrestrial Organism
Soil 172 - 187 000 ng/kg soil dw (2)
Hazard for Predators
Secondary poisoning 1.67 - 8.4 mg/kg food (2)

Short–term toxicity to fish

Study results
  • 5 studies submitted
  • 4 studies processed
P/RResults
LC50 (4 days) 100 mg/L [4]
LC50 (72 h) 100 mg/L [3]
LC50 (48 h) 100 mg/L [3]
LC50 (24 h) 100 mg/L [3]
LC100 (4 days) 100 mg/L [3]

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
LC50 for freshwater fish
100 mg/L

Long–term toxicity to fish

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 7 studies submitted
  • 3 studies processed
P/RResults
EC0 (24 h) 500 µg/L [2]
LC0 (24 h) 500 µg/L [1]
EC100 (24 h) 5.5 mg/L [2]
LC100 (24 h) 5.5 mg/L [1]

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other 1 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (21 days) 8.8 µg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 6 studies submitted
  • 3 studies processed
P/RResults
EC50 (72 h) 100 - 100 000 µg/L [5]
NOEC (72 h) 100 - 100 000 µg/L [2]
LOEC (72 h) 100 - 100 000 µg/L [2]

Type of Study provided
Studies with data
Key study 3
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 5 studies submitted
  • 3 studies processed
P/RResults
EC50 (3 h) 100 mg/L [1]
IC50 (3 h) 100 - 100 000 mg/L [2]
NOEC (3 h) 100 mg/L [2]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
LC10 (14 days) 1 g/kg soil dw [1]
LC50 (14 days) 1 g/kg soil dw [1]
LC100 (14 days) 1 g/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
1 g/kg soil dw

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 4 summaries submitted
  • 3 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.8 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 1 750 mg/m³ acute toxicity
Local Effects
Long-term: Hazard unknown (no further information necessary)
Acute /short term: Hazard unknown (no further information necessary)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 710 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 100 mg/kg bw/day acute toxicity
Local Effects
Long-term: No hazard identified
Acute /short term: (DNEL) 16.67 mg/cm² skin irritation/corrosion
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 430 µg/m³ repeated dose toxicity
Acute /short term: (DNEL) 875 mg/m³ acute toxicity
Local Effects
Long-term: Hazard unknown (no further information necessary)
Acute /short term: Hazard unknown (no further information necessary)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 360 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 50 mg/kg bw/day acute toxicity
Local Effects
Long-term: No hazard identified
Acute /short term: (DNEL) 16.67 mg/cm² skin irritation/corrosion
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 360 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 125 mg/kg bw/day acute toxicity
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 1 2
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential

Acute toxicity

Study results
oral
  • 6 studies submitted
  • 4 studies processed
P/RResults
LD50 5 000 mg/kg bw (rat) [2]
M/CInterpretations of results
Not classified [3]

Type of Study provided
oral
Studies with data
Key study 5
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
inhalation
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other 3
dermal
  • 5 studies submitted
  • 4 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [2]
M/CInterpretations of results
Not classified [3]

dermal
Studies with data
Key study 4
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 1 summary processed
Oral route:
No adverse effect observed Discriminating dose 5 000 mg/kg bw
Dermal route:
No adverse effect observed Discriminating dose 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 5
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Study data: eye
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 5
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 6
Supporting study 2
Weight of evidence
Other 2
Data waiving
no waivers
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 12 studies submitted
  • 4 studies processed
P/RResults
NOAEL (rat): 250 - 1 000 mg/kg bw/day [2]
NOAEL (dog): 1 000 mg/kg bw/day [1]
NOEL (rat): 50 - 100 mg/kg bw/day [2]
NOEL (dog): 10 mg/kg bw/day [2]

Type of Study provided
Study data: oral
Studies with data
Key study 7
Supporting study 2
Weight of evidence
Other 3
Data waiving
no waivers
Study data: inhalation
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons. 1
Other 1
Study data: dermal
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
M/C Summaries
  • 3 summaries submitted
  • 1 summary processed
Oral route - systemic effects:
Adverse effect observed NOAEL 10 mg/kg bw/day (subchronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 13 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 10
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
Study data: in vivo
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 1 1
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 4
Study data: developmental
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 4
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant