Occupational exposure limits - Call for comments and evidence

Occupational exposure limits - Call for comments and evidence

Occupational exposure limits - Call for comments and evidence

Calls for evidence allow parties to signal their interest and express their views and concerns in the early phases of developing a scientific report on occupational exposure limits on a substance or chemical agent at the workplace.

A call for evidence is additional to and does not take the place of the consultation on the OEL scientific report in support of occupational exposure limits at the workplace.

Consultations close at 23:59 Helsinki time (EET).

Previous call for evidence


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Substance Details

EC Number
CAS Number
Start of call
Deadline for providing input
Subject of the call
Call for evidence on Nitrosamines related to the scientific evaluation of exposure limits at the workplace.
Objective of the call

ECHA has been tasked by the European Commission to evaluate exposure to the following nitrosamines:

  • N-Nitrosodiethylamine (diethylnitrosoamine) (EC number 200-226-1; CAS RN 55-18-5)
  • N-Nitrosodimethylamine (Dimethylnitrosoamine) (EC number 200-549-8; CAS RN 62-75-9)
  • N-Nitroso di-n-propylamine (EC number 210-698-0; CAS RN 621-64-7)
  • N-Nitrosodiethanoamine (2,2'-(nitrosoimino)bisethanol) (EC number 214-237-4; CAS RN 1116-54-7)

to assess the option of an airborne occupational exposure limit, other limit values (BLV/BGV) and notations.

While the first nitrosamine listed above (EC number 200-226-1) has been self-classified as carcinogen 1B in the majority of ‘classification and labelling according to CLP criteria’ notifications, the other three chemicals (with EC numbers 200-549-8, 210-698-0 and 214-237-4) are carcinogens, classified as 1B.

All these nitrosamines may be present within rubber process dust and rubber process fumes.

This call intends to gather any new scientific information on uses, exposure, health effects, toxicology, epidemiology and modes of action of the above-mentioned nitrosamines, as well as any other relevant information (e.g. on similar substances).

The information gathered may be included in the evaluation when preparing the scientific report.

The scientific evaluations of exposure limits are used to support the regulatory initiatives on occupational exposure limit values for the protection of workers from chemical risks, to be set at EU level pursuant to Directive 2004/37/EC on the protection of workers from the risks related to exposure to carcinogens, mutagens or reprotoxic substances at work.

Target group
Industry, Academia, MSCAs, NGOs, Trade associations, Other stakeholders
Submit your contribution
Give Comments
Related documents
Background note
Related legislation
Carcinogens, Mutagens and Reprotoxic substances Directive 2004/37/EC

The information submitted may be non-confidential or confidential. If you claim information to be confidential, you will need to provide a justification. Any information claimed confidential will only be made available to ECHA, including its Committees, the Member State Competent Authorities and the European Commission, if appropriate.

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