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Diss Factsheets
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EC number: 439-070-6 | CAS number: 125005-87-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Report of an acute inhalation toxicity study using standard method, in accordance with EPA guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EPA 40 CFR 163.81-3
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 439-070-6
- EC Name:
- -
- Cas Number:
- 125005-87-0
- Molecular formula:
- Not applicable
- IUPAC Name:
- (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal (2S,3S,4S,5R)-2,3,4,5-tetrahydroxy-6-oxohexanoic acid acetic acid calcium dihydride hydrate magnesium dihydride potassium hydride sodium hydride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 215-300g weight at study start, housed in groups by sex (except during exposure) at 70 +/-2 degrees F and 30-60% RH.
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- Rats restrained individually within a 392L dynamic airflow exposure chamber. Spengler dust generator used to create test atmosphere (nominal concentration 4.9 mg/l based on sample weight consumed and air volume passing through exposure chamber). Achieved atmospheric concentration and particle size distribution measured.
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- Gravimetric measurement: atmospheric samples taken near animals breathing zone (6 minutes collection into vacuum sampler) 30,90,150 and 210 minutes after start of exposure.
- Duration of exposure:
- 4 h
- Concentrations:
- The test atmosphere (nominally 4.9 mg/l ) was determined by measurement to 0.316 mg/l (mean across sampling times).
Particle size distribution (measured using Andersen plate sampler during the final 15 minutes of exposure): 100% <10 microns, 28.9% =/<1.1 microns. - No. of animals per sex per dose:
- 5 males, 5 females.
- Control animals:
- yes
- Details on study design:
- After 14 days post-exposure observation, all rats were terminated: following gross pathology observations at necropsy, lungs and tracheal structures were collected into buffered formalin. Lungs and tracheal samples were also collected from a sample of rats taken at the time of animal delivery (pre-study) and from a supplementary non-exposed control group (additional to the air-exposed controls) at study termination.
- Statistics:
- Not applicable.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: NOAEC
- Effect level:
- 0.316 mg/L air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: Equal to a nominal exposure level of 4.9 mg/L
- Mortality:
- None
- Clinical signs:
- other: No significant treatment-related effects (intermittent nose-rubbing during exposure).
- Body weight:
- No effect on weight gain (test animals compared to exposed controls).
- Gross pathology:
- 3 test animals showed mottled lungs (one with areas of consolidation) and one showed a mottled kidney. Two unexposed controls showed mottled lungs.
- Other findings:
- Histopathology: indications of intercurrent infection (tracheitis, focal pneumonitis or peribronchitis) were seen in some rats, but the incidence and severity of this did not differ across test, exposed control and unexposed control groups.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- No evidence of toxicity was seen after 4-hour exposure of rats to a test substance dust atmosphere nominally 4.9 mg/l and measured at 0.316 mg/l. The difference between nominal and measured concentrations may indicate that close to a maximum practicable concentration was achieved.
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