Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-311-1 | CAS number: 105-58-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The performance of a study on the short-term toxicity to fish is not justified.
Key value for chemical safety assessment
Additional information
According to REACH Regulation (Annex VIII, 9.1.3, column 2), the study on the acute toxicity of fish does not need to be done if there are mitigating factors indicating that aquatic toxicity is unlikely to occur. In reliable experimental toxicity studies on toxic effects of diethyl carbonate to aquatic invertebrates (48 h EC50 >100 mg/L) and algae (72 h EC50>100 mg/L based on nominal concentrations each) an EC50 value could not be retrieved up to the highest test concentration applied.
Further experimental test results were reported for the acute toxicity of the structurally related carbonate ester dimethyl carbonate on Leuciscus idus: NOEC=1000 mg/L (study conducted acc. to OECD guideline 203; reliability not assignable).
The calculation of the acute toxicity of diethyl carbonate to fresh and marine water fish via ECOSAR v1.00 yielded 96 h LC50 values ranging from 45.1 to 419.4 mg/L. For adverse effects to different freshwater fish (Danio rerio, Oncorhynchus mykiss) after exposure to the structurally related carbonate esters dimethyl carbonate (DMC) and ethylmethyl carbonate (EMC), the QSAR Toolbox 3.1.0.21 predicts EC/LC50 values of > 100 mg/l (mortality, abnormal behaviour) for each of the substances, indicating a very low toxicity potential. Whereas most of the experimental as well as calculated values cited here, have to be regarded as not assignable as far as their reliability is concerned, the reported results clearly support the findings of daphnia and algal studies, that diethyl carbonate is of very low toxicity on aquatic organisms. Therefore, with respect to animal welfare, the performance of an acute fish study is assumed to be not justifiable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.