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EC number: 685-281-3 | CAS number: 2624-17-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Remarks:
- other: read-across from a subchronic study with an analogue
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The analogue CAS nº 108-80-5 cyanuric acid shares the same functional group with the substance CAS nº 2624-17-1 sodium cyanurate and the results can be extrapolated to sodium cyanurate.
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- other: read-across
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
- Principles of method if other than guideline:
- Read-across approach from a study report (using the methods outlined by the OECD Guideline 408) on the analogue CAS nº 108-80-5 cyanuric acid
- GLP compliance:
- yes
Test material
- Reference substance name:
- Cyanuric acid
- EC Number:
- 203-618-0
- EC Name:
- Cyanuric acid
- Cas Number:
- 108-80-5
- Molecular formula:
- C3H3N3O3
- IUPAC Name:
- 1,3,5-triazinane-2,4,6-trione
- Details on test material:
- - Name of test material (as cited in study report): Cyanuric acid
- Molecular formula (if other than submission substance): C3H3N3O3
- Molecular weight (if other than submission substance): 129.07
- Smiles notation (if other than submission substance): O=C1NC(=O)NC(=O)N1
- InChl (if other than submission substance): 1/C3H3N3O3/c7-1-4-2(8)6-3(9)5-1/h(H3,4,5,6,7,8,9)
- Structural formula attached as image file (if other than submission substance): see Fig.
Constituent 1
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- not examined
- Food efficiency:
- no effects observed
- Water consumption and compound intake (if drinking water study):
- no effects observed
- Ophthalmological findings:
- not examined
- Haematological findings:
- no effects observed
- Clinical biochemistry findings:
- no effects observed
- Urinalysis findings:
- no effects observed
- Behaviour (functional findings):
- not examined
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- effects observed, treatment-related
- Histopathological findings: non-neoplastic:
- no effects observed
- Details on results:
- Based on the experimental results obtained with the analogue cyanuric acid (NOAEL ca.231 mg/kg bw/day male; NOAEL ca. 914 mg/kg bw/day female; LOAEL ca. 109 mg/kg bw/day male; LOAEL ca. 915 mg/kg bw/day female), the read-across approach is applied and the NOAEL and LOAEL for substance sodium cyanurate are calculated to be NOAEL ca 272 mg/kg bw/day male; NOAEL ca. 1076 mg/kg bw/day female; LOAEL ca. 128 mg/kg bw/day male; LOAEL ca. 1078 mg/kg bw/day female under test conditions.
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 272 mg/kg bw/day (nominal)
- Sex:
- male
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 1 076 mg/kg bw/day (nominal)
- Sex:
- female
- Dose descriptor:
- LOAEL
- Effect level:
- ca. 128 mg/kg bw/day (nominal)
- Sex:
- male
- Dose descriptor:
- LOAEL
- Effect level:
- ca. 1 078 mg/kg bw/day (nominal)
- Sex:
- female
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
The analogue cyanuric acid shares the same functional group with the substance CAS nº 2624-17-1 sodium cyanurate and also has comparable values for the relevant molecular properties. These properties are:
- a low log Pow value which is -1.31 for cyanuric acid and 0.62 for sodium cyanurate,
- a high water solubility which is 2000 mg/L at 25 ºC for cyanuric acid and 22300 mg/L at 25 ºC for sodium cyanurate and
- similar molecular weights which are129.07 for cyanuric acid and 152.08 for sodium cyanurate.
As indicated in the European Chemical Agency Practical Guide 6 “How to report read –across and categories”, the structural grouping was realized using “OECD QSAR APPLICATION TOOL BOX” (see attachment).
Table 1: Data Matrix, Analogue Approach
CAS Number
|
108-80-5 |
2624-17-1 |
|
CHEMICAL NAME
|
Analogue 1 Cyanuric acid |
Sodium cyanurate |
|
PHYSICO-CHEMICAL DATA |
|||
Melting Point |
Experimental results: 320 - 440°C |
Estimated data: 305ºC |
|
Boiling Point |
No data |
Estimated data: 697.8ºC |
|
Density |
Experimental results: 1.75 g/ml |
Experimental results: 1.9 g/ml |
|
Vapour Pressure |
No data
|
Estimated data: 1.41E-016 mm Hg at 25ºC |
|
Partition Coefficient (log Kow) |
Experimental results: -1.31 at 25°C |
Estimated data: 0.62 |
|
Water solubility
|
Experimental results: 2000 mg/L at 25 ºC
|
Estimated data: 2.234E+004 mg/L at 25ºC |
|
ENVIRONMENTAL FATE and PATHWAY |
|||
Aerobic Biodegradation
|
Experimental results: Normally it degrades very slowly under aerobic conditions. Nevertheless, it can be readily degraded aerobically under nitrogen-limited conditions, but only by a limited number of microorganisms in certain conditions.
|
Read-across from Cyanuric acid: Normally it degrades very slowly under aerobic conditions. Nevertheless, it can be readily degraded aerobically under nitrogen-limited conditions, but only by a limited number of microorganisms in certain conditions.
|
|
Anaerobic Biodegradation |
Experimental results: Ready biodegradability |
Read-across from Cyanuric acid: Ready biodegradability
|
|
ENVIRONMENTAL TOXICITY |
|||
Acute Toxicity to Fish |
Experimental data: 96 h-LC50 > 1000 mg/L
|
Read-across from Cyanuric acid: 96 h-LC50 > 1178 mg/L
|
|
Acute Toxicity to Aquatic Invertebrates |
Experimental data: 48 h-LC50 > 1000 mg/L |
Read-across from Cyanuric acid: 48 h-LC50 > 1178 mg/L
|
|
Toxicity to Aquatic Plants
|
Experimental data: 96 h-EC50=712 mg/L (basis for effect: in vivo chlorophyll) 96 h-EC50=655 mg/L (basis for effect: cell number)
|
Experimental data: 72h-EC50 > 100 mg/L 72h-NOEC = 100 mg/L Experimental data: Sodium cyanurate monohydrate
72h-EbC50= 2700 mg/L (biomass) 72h- ErC50 > 5000 mg/L (growth rate) 72h- NOEC = 1250 mg/L (growth rate)
|
|
MAMMALIAN TOXICITY |
|||
Acute Oral |
Key study: LD50 > 5000 mg/kg bw |
Read-across from Cyanuric acid: LD50 > 5891 mg/kg bw
|
|
Acute Inhalation |
Key study: LC50 >5.25mg/L
|
Read-across from Cyanuric acid: LC50 >6.19mg/L
|
|
Acute Dermal |
Key study: LD50 > 5000 mg/kg bw |
Read-across from Cyanuric acid: LD50 > 5891 mg/kg bw
|
|
Repeated Dose |
Repeated dose toxicity: oral: Key study: 13 weeks in rats: NOAEL ca.231 mg/kg bw/day male NOAEL ca. 914 mg/kg bw/day female |
Repeated dose toxicity: oral: Key study: 28 days extended to 59 days in rats: LOAEL > 4000 ppm NOAEL = 4000 ppm Repeated dose toxicity oral: Key study: 104 weeks in mouse: NOAEL ca. 1520 mg/kg bw/day,male NOAEL ca. 1580 mg/kg bw/day, female Key study: Sodium cyanurate monohydrate:
Rat, 104 weeks
NOAEL ca. 154 mg/kg bw/day, male NOAEL ca. 266 mg/kg bw/day, female
|
|
Genetic Toxicity in vitro
|
Gene mutation in bacteria
|
No data |
Key study: Sodium cyanurate monohydrate: Negative |
Mammalian gene mutation
|
No data |
Key study: CHO, with and without metabolic activation, genotoxicity negative
|
|
Chromosomal aberration |
No data |
Key study: Mouse lymphoma L5178Y cells, with and without metabolic activation, genotoxicity negative
|
|
Genetic Toxicity in vivo
|
No data |
Key study: Rat bone marrow cytogenetics assay, genotoxicity negative
|
|
Carcinogenicity
|
No data |
Key study: Mouse, 104 weeks NOAEL ca. 1520 mg/kg bw/day, male NOAEL ca. 1580 mg/kg bw/day, female Key study: Sodium cyanurate monohydrate:
Rat, 104 weeks NOAEL ca. 154 mg/kg bw/day, male NOAEL ca. 266 mg/kg bw/day, female
|
|
Reproductive Toxicity |
No data
|
Key study: Rats, 100 and 120 days exposure- period of F0, F1 and F2 generations, both sexes. NOAEL: P male ca. 470 mg/kg bw/day P female ca. 950 mg/kg bw/day F1 male ca. 500 mg/kg bw/day F1 female ca. 910 mg/kg bw/day F2 male ca. 190 mg/kg bw/day F2 female ca. 970 mg/kg bw/day
Key study: Rabbit, developmental toxicity. NOAEL maternal = 50 mg/kg bw/day NOAEL teratogenicity = 500 mg/kg bw/day Key study: Sodium cyanurate monohydrate: Rat, developmental toxicity: NOAEL maternal = 5000 mg/kg bw/day NOAEL teratogenicity = 5000 mg/kg bw/day
|
Applicant's summary and conclusion
- Conclusions:
- The NOAEL and LOAEL for substance sodium cyanurate are calculated to be: NOAEL ca 272 mg/kg bw/day male; NOAEL ca. 1076 mg/kg bw/day female; LOAEL ca. 128 mg/kg bw/day male; LOAEL ca. 1078 mg/kg bw/day female.
- Executive summary:
Based on the experimental results obtained with the analogue cyanuric acid (NOAEL ca.231 mg/kg bw/day male; NOAEL ca. 914 mg/kg bw/day female; LOAEL ca. 109 mg/kg bw/day male; LOAEL ca. 915 mg/kg bw/day female) the read-across approach is applied and the NOAEL and LOAEL for substance sodium cyanurate are calculated to be NOAEL ca 272 mg/kg bw/day male; NOAEL ca. 1076 mg/kg bw/day female; LOAEL ca. 128 mg/kg bw/day male; LOAEL ca. 1078 mg/kg bw/day female under test conditions.
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