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EC number: 204-847-9 | CAS number: 127-52-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- Not applicable.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The data are mainly obtained by secondary source, therefore the information is limited.
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 002
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
- Objective of study:
- distribution
- excretion
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 417 (Toxicokinetics)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Tosylchloramide sodium
- EC Number:
- 204-854-7
- EC Name:
- Tosylchloramide sodium
- Cas Number:
- 127-65-1
- IUPAC Name:
- sodium chloro[(4-methylphenyl)sulfonyl]azanide
- Reference substance name:
- Chloramine T
- IUPAC Name:
- Chloramine T
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in studies):Chloramine T or Tosylchloramide sodium (purity n.p.)
- Molecular formula: C7-H8-Cl-N-O2-S.Na
- Molecular weight: 227,64375 g/mol
- Smiles notation: S(=O)(=O)(c1ccc(cc1)C)[N-]Cl.[Na+]
- InChl: 1S/C7H7ClNO2S.Na/c1-6-2-4-7(5-3-6)12(10,11)9-8;/h2-5H,1H3;/q-1;+1
- Structural formula attached as image file: see Fig.
- Substance type: Biocide, disinfectant
Constituent 1
Constituent 2
- Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- other: intravenous and oral
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Martínez et al, 1996:
-Group 1: Single dose – 30 mg/kg bw i.v.
-Group 2: Single dose – 100 mg/kg bw p.o.
- Details on dosing and sampling:
- Martínez et al, 1996:
-Sampling time Serial blood samples
-Body fluids sampled Group 1 and 2: Blood
- Tissues
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Distribution half-life: 0.12 hr (after i.v. dosing)
0.42 hr (after p.o. dosing) - Details on distribution in tissues:
- See table 2
Toxicokinetic parametersopen allclose all
- Test no.:
- #1
- Toxicokinetic parameters:
- half-life 1st: 1.41 hr (after i.v. dosing)
- Test no.:
- #2
- Toxicokinetic parameters:
- half-life 1st: 1.98 hr (after p.o. dosing)
- Test no.:
- #3
- Toxicokinetic parameters:
- other: Volume of distribution at steady state: 0.24 L
Metabolite characterisation studies
- Metabolites identified:
- no
Any other information on results incl. tables
Table 1 Excretion of HO36Cl in ratsa
Collection period (h) |
Proportion of HO36Cl excreted (%) |
||
|
Urine |
Faeces |
Total |
|
|
|
|
0-8 |
1.71±1.03 |
|
|
8-16 |
2.36±0.52 |
|
|
16-24 |
2.99±0.03 |
|
|
|
|
|
|
0-24 |
7.05±1.51 |
7.45±0.95 |
14.50±0.56 |
|
|
|
|
24-48 |
12.22±2.12 |
2.85±0.25 |
15.00±1.87 |
48-72 |
10.02±0.40 |
1.60±0.30 |
11.62±0.10 |
72-96 |
7.14±1.64 |
2.90±2.20 |
10.04±0.56 |
|
|
|
|
0-96 |
36.43±5.67 |
14.80±3.70 |
51.23±1.97 |
|
|
|
|
aValues represent mean±SE from four treated (fasted) rats, expressed as the proportion of administration dose. 36Cl was not detected in expired air throughout the 96 h studied.
Table 2 The distribution of 36Cl activity 96 h after administration of HO36Cl orally
Tissue |
36Cl activity (µg/g) |
|
|
Plasma |
1.92 |
Blood |
1.59 |
Bone marrow |
1.55 |
Testes |
1.26 |
Skin |
1.20 |
Kidney |
1.13 |
Lung |
1.04 |
Packed cells |
1.03 |
Duodenum |
0.71 |
Stomach |
0.70 |
Spleen |
0.67 |
Thyroid |
0.66 |
Thymus |
0.55 |
Liver |
0.51 |
Carcass |
0.40 |
Ileum |
0.26 |
Fat |
0.09 |
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
In the rat, tosylchloramide sodium is rapidly distributed throughout the body. Plasma clearance is relatively rapid, with elimination primarily through the urine. After 96 h, 36% was eliminated via the urine, whereas 15% was eliminated via faeces. - Executive summary:
Toxicokinetics of Chloramine-T after single 30 mg/kg i.v. and 100 mg/kg p.o. were studied in male Wistar Rats. Serial blood samples were collected and plasma concentrations of Chloramine-T were determined by HPLC method. Chloramine-T was characterized by a rapid distribution and elimination phase (distribution half-life 0.12 hr – i.v. and 0.42 hr. – p.o.; elimination half-life 1.41 hr – i.v. and 1.98 hr – p.o.). Plasma clearance was relatively high (0.147 L/hr – i.v., 0.149 L/hr – p.o.) with a volume of distribution at steady state of 0.24 L. Chloramine-T was found to be rapidly distributed and eliminated. After 96 h, 36% was eliminated via the urine, whereas 15% was eliminated via faeces.
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