Registration Dossier
Registration Dossier
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Diss Factsheets
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EC number: 432-130-2 | CAS number: 119345-01-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption
- Remarks:
- other: QSAR assessment of adsorption/desorption potential
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Study period:
- 16 February 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Substance is a phosphite ester based UVCB. Standard tests for this endpoint are intended for single substances and are not appropriate for this complex substance. However, this endpoint is characterized using quantitative structure property relationships for representative structures that comprise the potential structures available for exposure. Calculations have been conducted using the US EPA EPIWIN KOCWIN V2.0 model, which is considered to be an appropriate tool for substances of this type. The full report is attached below under "Additional Background Information".
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Please refer to the full report attached below under "Additional Background Information".
- GLP compliance:
- no
- Type of method:
- other: QSAR
- Media:
- other: Not applicable
Test material
- Reference substance name:
- -
- EC Number:
- 432-130-2
- EC Name:
- -
- Cas Number:
- 119345-01-6
- Molecular formula:
- Not applicable ( a generic molecular formula cannot be provided for this UVCB substance)
- IUPAC Name:
- Reaction products of phosphorous trichloride, with 1,1′-biphenyl and 2,4-bis(1,1-dimethylethyl)phenol
- Details on test material:
- Not applicable.
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Not applicable
Study design
- Test temperature:
- Not applicable
HPLC method
- Details on study design: HPLC method:
- Not applicable
Batch equilibrium or other method
- Analytical monitoring:
- not required
- Details on sampling:
- Not applicable
- Details on matrix:
- Not applicable
- Details on test conditions:
- Not applicable
- Computational methods:
- Not applicable
Results and discussion
Adsorption coefficientopen allclose all
- Type:
- log Koc
- Value:
- >= 3.955 - <= 18.171
- Remarks on result:
- other: Calculated using KOWWIN v2.0
- Type:
- Koc
- Value:
- >= 9 010 - <= 10 000 000 000
- Remarks on result:
- other: Calculated using KOWWIN v2.0
Results: HPLC method
- Details on results (HPLC method):
- Not applicable
Results: Batch equilibrium or other method
- Adsorption and desorption constants:
- Not applicable
- Recovery of test material:
- Not applicable
- Concentration of test substance at end of adsorption equilibration period:
- Not applicable
- Concentration of test substance at end of desorption equilibration period:
- Not applicable
- Details on results (Batch equilibrium method):
- Not applicable
- Statistics:
- Not applicable
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Alkanox P-EPQ is a reaction mass of phosphorous trichloride, with 1,1′-biphenyl and 2,4-bis(1,1-dimethylethyl)phenol. It is a UVCB molecule, comprising of variable phosphite ester type products. The proposed water solubility of the substance is very low (<1 mg/l at RTP). As such, it is proposed that conducting an assessment of adsorption/desorption using an experimental study is not appropriate given the known properties of the substance in water. These difficulties were also observed during assessment of the partition coefficient value for the substance, resulting in a calculation method being applied.
It was therefore deemed appropriate to assess the potential Adsorption / Desorption nature using a QSAR methodology, rather than an experimental test. Following review of QSAR programmes, KOCWIN™ (V2.0) was selected for use in assessing the substance. On the basis of the calculated results using KOCWIN v2.0, the following values are proposed in support of the registration dossier:
Log Koc – Range of 3.9547 to 18.1712
Koc (L/Kg) – Range of 9010 to 1.00E+10
This is indicative of the potential the majority of the UVCB material to display high adsorption to soil / sludge, which is expected given the low water solubility. Further assessment of this endpoint is not required at the level of registration currently being applied, hence any further review would be conducted at the next level of registration. - Executive summary:
Alkanox P-EPQ is a reaction mass of phosphorous trichloride, with 1,1′-biphenyl and 2,4-bis(1,1-dimethylethyl)phenol. Itis a UVCB molecule, comprising of variablephosphite ester type products.The proposed water solubility of the substance is very low (<1 mg/l at RTP). As such, it is proposed that conducting an assessment of adsorption/desorption using an experimental study is not appropriate given the known properties of the substance in water. These difficulties were also observed during assessment of the partition coefficient value for the substance, resulting in a calculation method being applied.
It was therefore deemed appropriate to assess the potential Adsorption / Desorption nature using a QSAR methodology, rather than an experimental test. Following review of QSAR programmes, KOCWIN™ (V2.0) was selected for use in assessing the substance. On the basis of the calculated results using KOCWIN v2.0, the following values are proposed in support of the registration dossier:
Log Koc – Range of 3.9547 to 18.1712
Koc (L/Kg) – Range of 9010 to 1.00E+10
This is indicative of the potential the majority of the UVCB material to display high adsorption to soil / sludge, which is expected given the low water solubility. Further assessment of this endpoint is not required at the level of registration currently being applied, hence any further review would be conducted at the next level of registration.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.