Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-701-1 | CAS number: 7691-02-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In the key skin irritation study conducted according to OECD Test guideline 404 and in compliance with GLP (Toxikon Corporation, 2007) N-(dimethylvinylsilyl)-1,1-dimethyl-1-vinylsilylamine was concluded to be not irritating to the skin of rabbits.
There are no eye irritation studies for N-(dimethylvinylsilyl)-1,1-dimethyl-1-vinylsilylamine, therefore good quality reliable data have been read-across from the structurally-related substance, 1,1,1,3,3,3-hexamethyldisilazane (CAS 999-97-3).
In the key eye irritation study, which was conducted according to OECD Test Guideline 405 and in compliance with GLP, 1,1,1,3,3,3-hexamethyldisilazane was not irritating to rabbit eyes (Dow Corning Corporation, 1993b).
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02.04.2007 to 08.10.2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- No test substance purity details.
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Millbrook Breeding Labs, Amherst, MA
- Age at study initiation: At least 10 weeks old
- Weight at study initiation: 2.07-2.19 kg
- Housing: Suspended stainless steel
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: Minimum five days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20± 5
- Humidity (%): 30-70
- Air changes (per hr): Minimum 10
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 04.10.2007 To: 08.10.20007 - Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml - Duration of treatment / exposure:
- Four hours
- Observation period:
- 72 hours (at 1, 24, 48 an 72 hours)
- Number of animals:
- Three
- Details on study design:
- TEST SITE
- Area of exposure: Trunk
- % coverage: Not less than 10%
- Type of wrap if used: Covered with a gauze patch, which was held in place with a semi-occlusive bandage.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, residual test substance was removed by washing with sterile water.
- Time after start of exposure: Four hours
SCORING SYSTEM: Equivalent to Draize. - Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- At the 1-hour time interval two animals had Grade 1 erythema. In one of these animals the Grade 1 erythema continued to 48 hours but was completely resolved by 72 hours. In the other the erythema had resolved by 24 hours. There were no signs of irritation in the third animal.
- Other effects:
- There were no overt signs of toxicity, and all animals gained weight during the study.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In the skin irritation study conducted according to OECD Test guideline 404 and in compliance with GLP, N-(dimethylvinylsilyl)-1,1-dimethyl-1-vinylsilylamine was concluded to be not irritating to the skin of rabbits.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07.09.1993 to 06.12.1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Age: Young male adult rabbits weighing between 2.7 and 2.85 kg
No further data - details taken from IUCLID 2008
TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: 2.7 to 2.85 kg
- Housing: Individually in stainless steel cages.
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: Seven days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data
IN-LIFE DATES: From: 26.10.1993 To: 29.10.1993 - Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml
- Concentration (if solution): undiluted - Duration of treatment / exposure:
- No washing
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- Three
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): Not done
SCORING SYSTEM: Draize
TOOL USED TO ASSESS SCORE: Fluorescein stain was used at the 24, 48, and 72-hour readings. Eyes were examined by slit illumination for ocular changes of the cornea, iris (internal effects) and conjunctiva. - Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Remarks:
- Both before and after stain
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Remarks:
- Both before and after stain
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Remarks:
- Both before and after stain
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- See Table 1. The test material caused slight conjunctival hyperemia in two animals and slight conjunctival chemosis in one animal at the 1 hour reading; these reactions had subsided at the subsequent readings (2 or 24 hours). The primary eye irritation score was calculated for the animals to be 0 (non-irritating).
- Other effects:
- A very slight immediate pain response was observed in all animals.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In the eye irritation study, which was conducted according to OECD Test Guideline 405 and in compliance with GLP, 1,1,1,3,3,3-hexamethyldisilazane was not irritating to rabbit eyes
Reference
Table 1 Mean irritation scores
Individual Tissue parameter | 1 hour | 2 hours | 24 hours | 48 hours | 72 hours |
Corneal Opacity | - | - | 0 | 0 | 0 |
Iridial inflammation | 0 | 0 | 0 | 0 | 0 |
Conjunctival irritation | |||||
Redness | 0.7 | 0 | 0 | 0 | 0 |
Chemosis | 0.3 | 0 | 0 | 0 | 0 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The key skin irritation study with N-(dimethylvinylsilyl)-1,1-dimethyl-1-vinylsilylamine was conducted according to OECD Test Guideline 405 and in compliance with GLP. No adverse skin reactions were observed at the 24, 48 and 72-hour observations following 4-hour, semioccluded application of undiluted test material onto rabbit skin (Toxicon Corporation, 2007).
In a skin irritation study with 1,1,1,3,3,3-hexamethyldisilazane (CAS 999-97-3), conducted according to OECD Test Guideline 404 and in compliance with GLP, 0.5 ml undiluted test substance was applied to one intact site of each animal (three New Zealand white rabbits), and the site was covered with porous gauze and then wrapped in a semi-occlusive cotton bandage (Dow Corning Corporation, 1993a). After a 4-hour exposure period the application site was washed with tap water. Skin reactions were scored at 1, 24, 48 and 72 hours and 7 days. No irritation was noted after 1 hour. Erythema was observed in 2/3 animals, at 24, 48 and 72 hours. All signs of irritation had reversed by day 7. The third animal showed no signs of irritation throughout the study. The primary dermal irritation score was calculated to be 1.22, and overall the conclusion was that the test substance was minimally irritating to the skin of rabbits, but not sufficient for classification.
There are no eye irritation studies for N-(dimethylvinylsilyl)-1,1-dimethyl-1-vinylsilylamine, therefore good quality reliable data have been read across from the structurally-related substance, 1,1,1,3,3,3-hexamethyldisilazane (CAS 999-97-3).
In the key eye irritation study, which was conducted according to OECD Test Guideline 405 and in compliance with GLP, 1,1,1,3,3,3-hexamethyldisilazane was not irritating to rabbit eyes (Dow Corning Corporation, 1993b). Following single instillation of undiluted test material into the eyes of three rabbits, a very slight immediate pain response was observed in all animals. The test material caused slight conjunctival hyperaemia in two animals and slight conjunctival chemosis in one animal at the 1-hour reading. These reactions had subsided at the subsequent readings (2 and 24 hours). The cornea, iris, conjunctivae and chemosis readings for all the animals were 0 at 24, 48 and 72 hours.
Justification for classification or non-classification
Based on the available measured and read-across data, N-(dimethylvinylsilyl)-1,1-dimethyl-1-vinylsilylamine is not classified for skin or eye irritation according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.