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EC number: 248-704-9 | CAS number: 27871-49-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Methanol CAS N°: 67-56-1
- Author:
- Anonymous
- Year:
- 2 004
- Bibliographic source:
- UNEP Publications: SIDS Initial Assessment Report SIAM 19, Berlin, Germany
- Report date:
- 2004
- Reference Type:
- other: unpublished data
- Title:
- Bericht zur Prüfung auf sensibilisierende Wirkung am Meerschweinchen-Maximierungstest (Magnusson und Kligman).
- Author:
- BASF AG
- Year:
- 1 979
- Bibliographic source:
- OECD SIDS. Methanol, UNEP Publication: SIDS Initial Assessment Report SIAM 19. Berlin Germany, 18-20 October 2004
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The study conducted was a modified Magnussen-Kligman test in guinea pigs.
- GLP compliance:
- not specified
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- Methanol
- EC Number:
- 200-659-6
- EC Name:
- Methanol
- Cas Number:
- 67-56-1
- Molecular formula:
- CH4O
- IUPAC Name:
- methanol
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: methanol
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- female
Study design: in vivo (non-LLNA)
Induction
- Route:
- intradermal and epicutaneous
- Vehicle:
- water
- Concentration / amount:
- 50%
- Day(s)/duration:
- 7 days ( 1 week between each treatment)
Challenge
- No.:
- #1
- Route:
- epicutaneous, occlusive
- Vehicle:
- water
- Concentration / amount:
- 50%
- No. of animals per dose:
- 1st study: 10 test animals, 5 control animals
2nd study: two studies with 12 test animals, 5 controls - Details on study design:
- Two studies were conducted using 10 test animals (1st study) and 24 test animals (2nd study) with each 5 control animals. During challenge in the first study, a formaldehyde solution (25 %) was applied in order to identify possible sensitisation effect that might be caused by metabolism-related transformation of methanol to formaldehyde.
The induction scheme was modified as follows (1 week between each treatment):
0.1 ml volume, 50 % test substance
- 1st intradermal induction (including 6 parallel injections with Freund´s Adjuvans solely, with methanol solely and both combined)
- 1st epidermal induction
- 2nd intradermal induction (including 4 parallel injections with methanol solely and combined with Freund´s Adjuvans)
- 2nd epidermal induction. - Challenge controls:
- Control groups
- Positive control substance(s):
- no
Results and discussion
In vivo (non-LLNA)
Results
- Remarks on result:
- other:
- Remarks:
- see box "Any other information on results incl. tables".
Any other information on results incl. tables
In the first study, no contact sensitisation was observed, in the parallel test with formaldehyde, also a negative result was seen. In the second study using 24 female animals (two tests à 12 animals), 1/12 (test 1) and 2/12 (test 2) exhibited a slight skin response (score 1) after 24 and 48 h which can be interpreted as a weak sensitising potential. The intracutaneous induction produced necroses and some open ulcerations.
In summary, the low number of 3/24 animals with score 1 gives no evidence of a notable sensitisation potential of methanol.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP criteria not met
- Conclusions:
- In the OECD SIDS report for methanol, a guinea pig maximization study is reported to be the key study for the assessment of a sensitizing potential of methanol. No evidence of a notable skin sensitization potential of methanol was derived based on the results.
- Executive summary:
In the OECD SIDS report for methanol (2004), guinea pig maximization studies are reported to be the key studies for the assessment of a sensitizing potential of methanol. A first guinea pig maximization test gave no evidence of contact sensitisation in 10 female animals after induction and challenge with a 50 % aqueous methanol solution (0.1 mL). In a second guinea pig sensitization test using 24 female animals (two tests with 12 animals each), 1 of 12 (test 1) and 2 of 12 (test 2) animals exhibited a slight skin response (score 1) after 24 and 48 hours. In summary, the low number (3 of 34) animals with a score of 1 show no notable sensitisation potential of methanol.
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