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EC number: 272-574-2 | CAS number: 68890-66-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Monitoring data
Administrative data
- Endpoint:
- monitoring data
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Sampling and analytical method from the valid OECD 303A (IUCLID Section 5.2.2) study was establish STP Monitoring data for Octopirox. Therefore this study is reliable without restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Sampling method and analytical from the STP Simulation study OECD 303A (see IUCLID Section 5.2.2) was used and the analytical method verified for the STP Measurements
- GLP compliance:
- no
- Remarks:
- Sampling and analytical measurements in sewage influent and activated sludge used the methods described in the GLP study OECD 303A described in IUCLID Section 5.2.2 but GLP was not fully implemented for cost reasons.
- Type of measurement:
- other: concentrations in two municipals STPs
- Media:
- other: Determination of concentrations in STP Sewage influent and in activated sludge
Test material
- Reference substance name:
- 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
- EC Number:
- 272-574-2
- EC Name:
- 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
- Cas Number:
- 68890-66-4
- Molecular formula:
- C14H23NO2.C2H7NO
- IUPAC Name:
- 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
- Reference substance name:
- Octopriox
- IUPAC Name:
- Octopriox
- Details on test material:
- as specified before
Constituent 1
Constituent 2
Study design
- Details on sampling:
- A series of samples was taken. Samples from Hildesheim were taken on Monday, 2006-01-30 – Wednesday, 2006-02-01 and Friday, 2006-02-03. Samples from Hannover were taken on Thursday, 2006-02-09 and Friday 2006-02-10. Influent samples as well as activated sludge samples were grab samples. Influent samples were taken at the end of the primary settler. Sludge samples were taken from the activated sludge tank .
Sample preparation was carried out as described in the analytical report „Analytical Method for Determination of Octopirox in Activated Sludge and Effluent for a Simulation Test – Aerobic Sewage Treatment” (2006-01-24) see IUCLID Section 5.2.2. To 25 mL of sewage influent (without any further pre-treatment) 1.25 mL TiCl3 solution were added and mixed. After 10 min 5 mL of the solution were cleaned up over C18-SPE cartridges. Elution was carried out with 5 mL of Methanol and the eluate used for LC MS/MS analysis. 10 mL activated sewage sludge were centrifuged for 10 min at 3000 rpm. The supernatant was rejected. 0.5 mL TiCl3 solution were added and the samples were filled up to 10 mL with HPLC water. The extraction was carried out on a gyratory shaker for 1 h at 300 rpm. Afterwards the samples were centrifuged for 10 min at 3000 rpm. The supernatant was diluted with HPLC water if necessary and analysed. Results were calculated related to the sludge dry weight.
Results and discussion
- Details on results:
- The analysis of Octopirox from two series of samples confirmed the presence of Octopirox in both sewage influent and sewage sludge. The concentrations measured for two sewage treatment plants were different. Whereas the sewage influent of STP Hannover had lower concentrations of Octopirox, the concentration in activated sewage sludge was higher compared to STP Hildesheim.
Octopirox concentration in raw sewage influent of the municipal sewage treatment plant in Hildesheim was in a range of 0.92 – 1.35 µg/l. The concentration of Octopirox in activated sewage sludge was 3.40 – 4.06 mg/kg dw.
For the municipal sewage treatment plant in Hannover Octopirox concentration in the raw sewage influent was in a range of 0.30 – 0.55 µg/L and 4.66 – 5.30 mg/kg dw in activated sewage sludge.
Recovery rates of the fortification tests confirm the robustness of the analytical method for the determination of Octopirox in raw sewage influent and activated sewage sludge of municipal sewage treatment plants.
Applicant's summary and conclusion
- Conclusions:
- The measured Sewage influent concentrations measured in two Sewage Treatment Plants (Hanover and Hildesheim, Germany) are by a factor of more than 5 lower than estimated by the Exposure Modelling Program EUSES 2.1. The concentrations of Octopirox in the activated Sludge of the STPs are by a factor of more than 6 lower than estimated by EUSES 2.1. One possible explantion could be that Octopirox may have a lower use rate in the area where these STPs are located.
- Executive summary:
The analysis of Octopirox from two series of samples confirmed the presence of Octopirox in both sewage influent and sewage sludge. The concentrations measured for two sewage treatment plants were different. Whereas the sewage influent of STP Hannover had lower concentrations of Octopirox, the concentration in activated sewage sludge was higher compared to STP Hildesheim. Octopirox concentration in raw sewage influent of the municipal sewage treatment plant in Hildesheim was in a range of 0.92 – 1.35 µg/l. The concentration of Octopirox in activated sewage sludge was 3.40 – 4.06 mg/kg dw. For the municipal sewage treatment plant in Hannover Octopirox concentration in the raw sewage influent was in a range of 0.30 – 0.55 µg/L and 4.66 – 5.30 mg/kg dw in activated sewage sludge. Recovery rates of the fortification tests confirm the robustness of the analytical method for the determination of Octopirox in raw sewage influent and activated sewage sludge of municipal sewage treatment plants.
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