Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 5.2 µg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 52 µg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.52 µg/L
- Assessment factor:
- 10 000
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 65 000 µg/L
- Assessment factor:
- 1
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- no exposure of sediment expected
Sediment (marine water)
- Hazard assessment conclusion:
- no exposure of sediment expected
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.62 µg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
The aquatic toxicity of beta-mannosidase was based on a read-across from alpha-amylase as the two enzymes are similiar. In addition, since alpha-amylase has a high toxicity towards aquatic organisms, it has been chosen as a worst-case scenario.
The aquatic toxicity data for alpha-amylase were obtained from short term toxicity studies in species representing two trophic levels (i.e. algae and crustaceans). The most sensitive aquatic organism was the green alga Desmodesmus subspicatus and thus the ECr50 value of 5200 µg active enzyme protein (aep)/L detected in the algal growth inhibition assay was used for PNEC derivation and the assessment factors 1000 and 10000 were applied for fresh and marine water, respectively.
Conclusion on classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
