Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-634-0 | CAS number: 123-54-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Adopted according to OECD SIDS (publicly available peer reviewed source). Original document not available.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 001
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
Materials and methods
- Principles of method if other than guideline:
- First experiment: 5 Rats per dose group were dosed with 0, 100, 500, or 1000 mg/kg bw of 2,4-pentanedione by gavage once a day. The doses were administered 1 to 11 times over a 1-15 day period. Controls received distilled water. In the 100 mg/kg bw dose group a 11th (lethal) dose of 1000 mg/kg bw was given.
Second experiment: An additional group of 5 male rats received 100 mg/kg bw of 2,4-pentanedione ten times over a 14 d period. 5 male control animals received 100 mg/kg bw of distilled water. - GLP compliance:
- not specified
- Limit test:
- no
Test material
- Details on test material:
- Purity: ca. 100%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 1-15 days
- Frequency of treatment:
- 1-11 applications
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100, 500, 1000 mg/kg bw
Basis:
actual ingested
- No. of animals per sex per dose:
- 5 rats per dose
- Control animals:
- yes, concurrent vehicle
Results and discussion
Results of examinations
- Details on results:
- First experiment:
1000 mg/kg bw: rapid onset of dyspnea and depression followed by prostration and death of all rats within 1 h after first dosing; no 2,4-pentanedione related changes at autopsy.
500 mg/kg bw: like high dose rats except that tremors and ataxia were observed; 3/5 rats died and 2/5 were sacrificed due to poor condition after 4 applications. Autopsy: 2/5 rats with poor haircoats, 1/5 distended bladder, congested lungs, clouding of cornea; histopathology: thymic necrosis (4/5), hepatocytes swelling and hepatic congestion (3/5), nephrosis (1/5), lymphadenitis in inesenteric lymph nodes (2/5), inflammation of the heart (3/5).
100 mg/kg bw: slight depression after applications (persisted 24 h in one rat which developed head tilt to the left side). All rats died after the final application of 1000 mg/kg or were sacrificed in moribund state. Histopathologically no 2,4-pentanedione related changes.
Second experiment: no differences between the 100 mg/kg dose group and the control group with regard to clinical signs, weight gain, hematology, clinical chemistry, organ weights, gross pathology and histopathology.
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 100 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: No mortality occurred and no clinical signs were observed.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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