Methyl L-threoninate

Explosiveness

Administrative data

Endpoint:

explosiveness, other

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2013-03-19 to 2013-11-06

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2013

Report date:

2013

Materials and methods

Test guideline

Qualifier:

no guideline followed

Guideline:

other: Theoretical consideration of the structure of L-TME

Principles of method if other than guideline:

According to the United Nations Committee of Experts on the Transport of Dangerous Goods explosive properties are associated with the presence of certain chemical groups in a molecule which can react to produce a very rapid increase in temperature or pressure. Thus, it is possible to examine the chemical structure of a substance and ascertain whether or not there are any groups present that are associated with explosive properties. For this purpose a list of screening procedures has been published in Appendix 6 of the United Nations ‘Recommendations on the Transport of Dangerous Goods, Manual of Tests and Criteria’.
The initial assessment of explosive properties is made by examining the chemical structures of the components with a list of functional groups that may indicate explosive properties in organic materials.

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

Methyl L-threoninate

EC Number:

222-158-1

EC Name:

Methyl L-threoninate

Cas Number:

3373-59-9

Molecular formula:

C5H11NO3

IUPAC Name:

Methyl (2S,3R)-2-amino-3-hydroxy-butanoate

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Details on test material:

- Name of test material (as cited in study report): L-threonine methyl ester
- Physical state: white crystalline powder
- Analytical purity: 99.8%
- Lot/batch No.: X5UYC99
- Expiration date of the lot/batch: July 2014
- Storage condition of test material: Frozen

Results and discussion

Results of test series for explosives

Test series:

other: Theoretical consideration of the structure of L-TME

Method:

other: Theoretical consideration of the structure of L-TME

Parameter:

other: Theoretical consideration of the structure of L-TME

Value:

0

Result:

other: Theoretical consideration of the structure of L-TME

Remarks on result:

not measured/tested

Any other information on results incl. tables

From an examination of the chemical structure of the test substance, it was concluded that it contained no functional groups which are characteristic of explosive properties.

Applicant's summary and conclusion

Interpretation of results:

non explosive

Remarks:

Migrated information

Conclusions:

From the assessment of the chemical structure it was established that L-TME would not have explosive properties.

Executive summary:

L-TME does not have functional groups characteristic of explosive properties as assessed from the chemical structure of L-TME.