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EC number: 406-250-0 | CAS number: 72619-32-0 HALOXYFOP R-(+)-ME HERBICIDAL CHEMICAL
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to terrestrial plants
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to terrestrial plants: short-term (with study design considered suitable for long-term assessment)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 208 (Terrestrial Plants, Growth Test)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- EF-1400
Lot #: NA12150104
Active ingredient: 114 g Haloxyfop-R-methyl/L - Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 156 g a.e./ha
- Sample storage conditions before analysis: Frozen - Vehicle:
- yes
- Remarks:
- Tap water
- Details on preparation and application of test substrate:
- When application rates were > 26.0 g ae/ha aliquots of test substance were diluted in Letcombe tap water and made up to a final spray volume of 200 mL spray solution. When the application was < or equal to 26.0 g ae/ha a 10 mL stock solution was prepared, aliquots of the stock solution were then made up to a total volume of 200 mL using Letcombe mains tap water. Treatment solutions were freshly prepared on the day of application.
- Species:
- Avena sativa
- Plant group:
- Monocotyledonae (monocots)
- Details on test organisms:
- - Common name: Cultivated oat
- Plant family: Gramineae
- Variety: Dula
- Source of seed: Herbiseed, UK LTD - Species:
- other: Cyperus esculentus
- Plant group:
- Monocotyledonae (monocots)
- Details on test organisms:
- - Common name: Yellow nutsedge
- Plant family: Cyperaceae
- Source of seed: Herbiseed, UK LTD - Species:
- Allium cepa
- Plant group:
- Monocotyledonae (monocots)
- Details on test organisms:
- - Common name: Onion
- Plant family: Liliaceae
- Variety: Marco F1
- Source of seed: Nickerson - Zwaan Netherlands - Species:
- Glycine max (G. soja)
- Plant group:
- Dicotyledonae (dicots)
- Details on test organisms:
- - Common name: Soybean
- Plant family: Leguminosae
- Variety: Gemma
- Source of seed: Soybean Gar one crop - Species:
- Brassica napus
- Plant group:
- Dicotyledonae (dicots)
- Details on test organisms:
- - Common name: Oilseed rape
- Plant family: Brassicaceae
- Variety: Apex
- Source of seed: Nickerson - Zwaan Netherlands - Species:
- Beta vulgaris
- Plant group:
- Dicotyledonae (dicots)
- Details on test organisms:
- - Common name: Sugar beet
- Plant family: Chenopodiaceae
- Variety: Saxon
- Source of seed: Hilleshog UK - Test type:
- other: Toxicity to plants
- Study type:
- other: Glasshouse conditions
- Substrate type:
- natural soil
- Limit test:
- no
- Remarks:
- Single application
- Post exposure observation period:
- 21 days
- Test temperature:
- 13-32.65°C
- pH:
- 7.15
- Details on test conditions:
- TEST SYSTEM
- Testing facility:
- Test container (type, material, size): 9 x 9 x 10 cm pot (except for Glycine max which is 11 x 11 x 12 cm pot)
- Amount of soil:
- Method of seeding:
- No. of seeds per container: 5 (A. sativa)
- No. of plants per container: 3 plants for C. esculentus, A. cepa, B. napus, B. vulgaris; 2 plants for G. max
PROPERTIES OF SUBSTRATE
- Soil texture: Sandy loam
- % sand: 74
- % silt: 14
- % clay: 12
- pH measured in CaCl2: 6.31
- Organic matter (%): 1.1
- CEC: 4.0 meq/100 g
GROWTH CONDITIONS
- Photoperiod: 14 hours lighting
- Light source: High pressure sodium vapour lamps
- Light intensity and quality: 140 µmole/m2/sec (PAR 400-700 nm)
- Day/night temperatures: 18/15°C
- Volume applied: 200 L/ha
- Method of application: Mardrive laboratory track sprayer (BDSPR02), TeeJet nozzle SS8003, reservoir pressure 2.1 BAR - Nominal and measured concentrations:
- 0, 0.81, 1.62, 3.25, 6.50, 13, 26, 39, 52, 104, 156 g a.e./ha
- Species:
- Avena sativa
- Dose descriptor:
- EC25
- Effect conc.:
- 16 g/ha
- Nominal / measured:
- acid equivalent
- Conc. based on:
- act. ingr.
- Basis for effect:
- phytotoxicity
- Remarks:
- foliar fresh weight
- Remarks on result:
- other: 20 day observation
- Key result
- Species:
- Avena sativa
- Dose descriptor:
- EC50
- Effect conc.:
- 19.8 g/ha
- Nominal / measured:
- acid equivalent
- Conc. based on:
- act. ingr.
- Basis for effect:
- phytotoxicity
- Remarks:
- foliar fresh weight
- Remarks on result:
- other: 20 day observation
- Species:
- Allium cepa
- Dose descriptor:
- EC25
- Effect conc.:
- > 156 g/ha
- Nominal / measured:
- acid equivalent
- Conc. based on:
- act. ingr.
- Basis for effect:
- phytotoxicity
- Remarks:
- foliar fresh weight
- Remarks on result:
- other: highest dose tested
- Key result
- Species:
- Allium cepa
- Dose descriptor:
- EC50
- Effect conc.:
- > 156 g/ha
- Nominal / measured:
- acid equivalent
- Conc. based on:
- act. ingr.
- Basis for effect:
- phytotoxicity
- Remarks:
- foliar fresh weight
- Remarks on result:
- other: highest dose tested
- Species:
- other: Cyperus esculentus
- Dose descriptor:
- EC25
- Effect conc.:
- > 156 g/ha
- Nominal / measured:
- acid equivalent
- Conc. based on:
- act. ingr.
- Basis for effect:
- phytotoxicity
- Remarks:
- foliar fresh weight
- Remarks on result:
- other: highest dose tested
- Key result
- Species:
- other: Cyperus esculentus
- Dose descriptor:
- EC50
- Effect conc.:
- > 156 g/ha
- Nominal / measured:
- acid equivalent
- Conc. based on:
- act. ingr.
- Basis for effect:
- phytotoxicity
- Remarks:
- foliar fresh weight
- Remarks on result:
- other: highest dose tested
- Species:
- Brassica napus
- Dose descriptor:
- EC25
- Effect conc.:
- > 156 g/ha
- Nominal / measured:
- acid equivalent
- Conc. based on:
- act. ingr.
- Basis for effect:
- phytotoxicity
- Remarks:
- foliar fresh weight
- Remarks on result:
- other: highest dose tested
- Key result
- Species:
- Brassica napus
- Dose descriptor:
- EC50
- Effect conc.:
- > 156 g/ha
- Nominal / measured:
- acid equivalent
- Conc. based on:
- act. ingr.
- Basis for effect:
- phytotoxicity
- Remarks:
- foliar fresh weight
- Remarks on result:
- other: highest dose tested
- Species:
- Glycine max (G. soja)
- Dose descriptor:
- EC25
- Effect conc.:
- > 156 g/ha
- Nominal / measured:
- acid equivalent
- Conc. based on:
- act. ingr.
- Basis for effect:
- phytotoxicity
- Remarks:
- foliar fresh weight
- Remarks on result:
- other: highest dose tested
- Key result
- Species:
- Glycine max (G. soja)
- Dose descriptor:
- EC50
- Effect conc.:
- > 156 g/ha
- Nominal / measured:
- acid equivalent
- Conc. based on:
- act. ingr.
- Basis for effect:
- phytotoxicity
- Remarks:
- foliar fresh weight
- Remarks on result:
- other: highest dose tested
- Species:
- Beta vulgaris
- Dose descriptor:
- EC25
- Effect conc.:
- > 156 g/ha
- Nominal / measured:
- acid equivalent
- Conc. based on:
- act. ingr.
- Basis for effect:
- phytotoxicity
- Remarks:
- foliar fresh weight
- Remarks on result:
- other: highest dose tested
- Key result
- Species:
- Beta vulgaris
- Dose descriptor:
- EC50
- Effect conc.:
- > 156 g/ha
- Nominal / measured:
- acid equivalent
- Conc. based on:
- act. ingr.
- Basis for effect:
- phytotoxicity
- Remarks:
- foliar fresh weight
- Remarks on result:
- other: highest dose tested
- Conclusions:
- EC50 (Allium cepa, Cyperus esculentus, Brassica napus, Glycine max, Beta vulgaris): > 156 g a.e./ha
EC50 (Avena sativa): 19.8 g a.e./ha - Executive summary:
This study was established to determine the EC25 and EC50 values (expressed in g a.e./ha) for test substance to a range of monocotyledons and dicotyledon species. The methodology is based on OCED guideline 208.
Applications were made post-emergence, in a total volume of 200 L/ha. Applications rates ranged from 0.81 to 156 g a.e./ha.
In total 3 monocotyledon and 3 dicotyledon species, from six different families were tested. The species evaluated represented members of the Gramineae, Liliaceae, Cyperaceae, Brassicaceae, Leguminosae and Chenopodiaceae. The growth stage at application ranged from BBCH 12-14 depending on the species. The plant species were raised, and the study was conducted under glasshouse conditions.
Visual injury was assessed on a 0-100 linear scale at approximately 7-day interval post application. At the final assessment timing (20 or 21 days depending on species) both visual injury and foliar fresh weight were recorded. EC25 and EC50 values were calculated for the foliar fresh weight using Minitab Statistical package 12.2.
The high tolerance of Allium cepa, Cyperus esculentus, Brassica napus, Glycine max and Beta vulgaris to the test substance resulted in minimal injury being observed on these species. Therefore, it was not possible to carry out regression analysis on the foliar fresh weight data and to predict the EC values. The EC25 and EC50 values were estimated to be >156 g a.e./ha.
Avena sativus was the only test species, which was sensitive to applications of the test substance at some of the higher rates tested. The EC25 and EC50 values calculated for foliar fresh weight data were 16.0 and 19.8 g a.e./ha respectively, the R Sq for the model used was 0.97.
Reference
Description of key information
EC50 19.8 g a.e./ha = 0.014 mg haloxyfop/kg soil dw exposed as a formulation (EF-1400). OECD 208; Reliability = 1
Key value for chemical safety assessment
- Short-term EC50 or LC50 for terrestrial plants:
- 0.014 mg/kg soil dw
Additional information
The EC50 expressed as g a.e./ha was converted into mg a.s./kg soil dry weight using the below information nad assumptions:
EF-1400, 108 g a.s./L (10.49% w/w) (104 g a.e./L; acid equivalent factor: 0.963; density=1.03 g/mL)
Standard soil mass at 1 cm depth: 1.5 g/cm3 (1cm used since soil was sprayed on the surface rather than mixed into soil)Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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