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Diss Factsheets
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EC number: 207-019-5 | CAS number: 422-61-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 2008
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test:
The acute inhalation toxicity of MTDID 7908 was evaluated in male Sprague Dawley rats following a 30 minute or 4 hour exposure. The study design followed a custom protocol. Male rats (3/group) were whole body exposed to the vaporized test material at concentrations of 800 or 2400 ppm for 30 minutes; 280 and 850 ppm as 4-hour equivalents, respectively.
- Parameters analysed / observed: Clinical signs were noted during exposure and daily thereafter. Gross necropsy was conducted following a 14 day observation period. - GLP compliance:
- no
- Test type:
- other: Custom protocol
- Limit test:
- no
Test material
- Reference substance name:
- Perfluoropropionyl fluoride
- EC Number:
- 207-019-5
- EC Name:
- Perfluoropropionyl fluoride
- Cas Number:
- 422-61-7
- Molecular formula:
- C3F6O
- IUPAC Name:
- pentafluoropropanoyl fluoride
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 3M Company, Lot 9
- Expiration date of the lot/batch: No data
- Purity test date: 13 July, 2008
FORM AS APPLIED IN THE TEST: The liquid test article was heated to form a vapor.
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan
- Females (if applicable) nulliparous and non-pregnant: NA
- Age at study initiation: No data
- Weight at study initiation: No data
- Fasting period before study: No data
- Housing: Group houses in standard solid-bottom cages
- Diet (e.g. ad libitum): Harlan Teklad Rat/Mouse 2018 Diet, ad libitum
- Water (e.g. ad libitum): Tap water, ad libitum
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- Temperature (C): 20.6-23.9
- Humidity (%): 30-70
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 14 July, 2008 To: 30 July 2008
Administration / exposure
- Route of administration:
- inhalation: gas
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: 40 liter test chamber
- Exposure chamber volume: 40 liters
- Method of holding animals in test chamber: None, whole body exposure
- Source and rate of air: No data
- Method of conditioning air: No data
TEST ATMOSPHERE
- Brief description of analytical method used: No data - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- ca. 30 - ca. 240 min
- Remarks on duration:
- Two exposures were conducted, one for 30 minutes and the other for 4 hours.
- Concentrations:
- Male rats (3/group) were whole body exposed to the vaporized test material at concentrations of 800 or 2400 ppm for 30 minutes; 280 and 850 ppm as 4-hour equivalents, respectively. Additional male rats (3/group) were whole body exposed to the vaporized test material at concentrations of 100 or 300 ppm for 4 hours.
- No. of animals per sex per dose:
- 3 males per group
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 300 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No mortality occurred during the study.
- Clinical signs:
- other: Irregular respiration rate, lethargy and labored breathing were noted in animals exposed for 30 minutes at 800 or 2400 ppm. No other abnormal clinical signs were noted in any groups throughout the study.
- Body weight:
- No abnormal body weight changes were identified during the study.
- Gross pathology:
- There were no abnormal pathological findings upon necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- other: The classification cannot be determined from this study alone. See endpoint summary for weight of evidence conclusion.
- Remarks:
- The classification cannot be determined from this study alone. See endpoint summary for weight of evidence conclusion.
- Conclusions:
- The 4-hour inhalation LC50 for MTDID 7908 is considered to be greater than 300 ppm in rats.
- Executive summary:
The acute inhalation toxicity of MTDID 7908 (a gas) was evaluated in male Sprague Dawley rats following a 30 minute or 4 hour exposure. The study design followed a custom protocol. Male rats (3/group) were whole body exposed to the test material at concentrations of 800 or 2400 ppm for 30 minutes; 280 and 850 ppm as 4-hour equivalents, respectively. Additional male rats (3/group) were whole body exposed to the test material at concentrations of 100 or 300 ppm for 4 hours. The rats were terminated at 14 days post-exposure. Parameters evaluated: clinical observations, body weights, food consumption, and macroscopy. Irregular respiration rate, lethargy and labored breathing were noted during exposure in animals exposed for 30 minutes at 800 or 2400 ppm; animals appeared normal after exposure termination. No other abnormal clinical signs, body weight changes, food consumption changes or macroscopic observations were noted in any groups throughout the study. The 4-hour inhalation LC50 for MTDID 7908 is considered to be greater than 300 ppm in rats.
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