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EC number: 814-602-3 | CAS number: 190454-06-9
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 March 2018 to 14 September 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- 2004
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
- Version / remarks:
- 1996
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EC Guideline A.24. Partition Coefficient (n-octanol/water), High Performance Liquid Chromatography (HPLC) Method.
- Version / remarks:
- 2016
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 7.2
- Temp.:
- 35 °C
- pH:
- 7
- Key result
- Type:
- Pow
- Partition coefficient:
- > 16 000 000
- Temp.:
- 35 °C
- pH:
- 7
- Details on results:
- In the chromatogram of the test material solution, several peaks with a retention time between 23.3 and 36.8 minutes were observed. Under the same analytical conditions, the retention time of 4,4’-DDT (log Pow = 6.5) was 11.4 and the retention time of benzo[ghi]perylene (log Pow = 7.2) was 18.2 minutes.
It was concluded that the log Pow of test material was > 7.2 (Pow > 1.6 x 10^7). - Conclusions:
- Under the conditions of this study the log Pow (and Pow) values of the test material at neutral pH were > 7.2 (Pow > 1.6 x 10^7).
- Executive summary:
The partition coefficient of the test material was investigated in accordance with the standardised guidelines OECD 117, EU Method A.24 and OPPTS 830.7570, under GLP conditions using the HPLC method.
In the chromatogram of the test material solution, several peaks with a retention time between 23.3 and 36.8 minutes were observed. Under the same analytical conditions, the retention time of 4,4’-DDT (log Pow = 6.5) was 11.4 and the retention time of benzo[ghi]perylene (log Pow = 7.2) was 18.2 minutes. It was concluded that the log Pow of test material was > 7.2 (Pow > 1.6 x 10^7).
Under the conditions of this study the log Pow (and Pow) values of the test material at neutral pH were > 7.2 (Pow > 1.6 x 10^7).
Reference
Description of key information
Under the conditions of the study the log Pow (and Pow) values of the test material at neutral pH were > 7.2 (Pow > 1.6 x 10^7).
Key value for chemical safety assessment
Additional information
The partition coefficient of the test material was investigated in accordance with the standardised guidelines OECD 117, EU Method A.24 and OPPTS 830.7570, under GLP conditions using the HPLC method. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
In the chromatogram of the test material solution, several peaks with a retention time between 23.3 and 36.8 minutes were observed. Under the same analytical conditions, the retention time of 4,4’-DDT (log Pow = 6.5) was 11.4 and the retention time of benzo[ghi]perylene (log Pow = 7.2) was 18.2 minutes. It was concluded that the log Pow of test material was > 7.2 (Pow > 1.6 x 10^7).
Under the conditions of this study the log Pow (and Pow) values of the test material at neutral pH were > 7.2 (Pow > 1.6 x 10^7).
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