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EC number: 220-482-8 | CAS number: 2781-11-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- old study report with limited documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 2074
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- 1981
- GLP compliance:
- no
- Test type:
- traditional method
- Limit test:
- no
Test material
- Reference substance name:
- Diethyl bis(2-hydroxyethyl)aminomethylphosphonate
- EC Number:
- 220-482-8
- EC Name:
- Diethyl bis(2-hydroxyethyl)aminomethylphosphonate
- Cas Number:
- 2781-11-5
- Molecular formula:
- C9H22NO5P
- IUPAC Name:
- diethyl {[bis(2-hydroxyethyl)amino]methyl}phosphonate
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Color: yellow-brown
- Form: liquid
- Relative density: 1.164 (at 20°C)
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Breeder Winkelmann, Borchen, Germany
- Weight at study initiation: 160-180 g
- Housing: 5 animals of same sex per cage in makrolon cages (type III)
- Diet: "Altromin-R-Standardkost" ad libitum
- Water: tap water ad libitum
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- System of generating aerosols: The test substance was mixed with a solution of alcohol-Lutrol (1:1) containing oil red and sprayed in the inhalation chambers.
TEST ATMOSPHERE
- Brief description of analytical method used: Spray mist from the inhalation chamber was absorbed with cotton wool and oil red was extracted with Xylol. The concentration of the test substance in the air was indirectly measured by the extinction of the red coloured solution at 525 nm (the amount of oil red/L air equals the amount of test substance).
- Samples taken from breathing zone: yes - Duration of exposure:
- >= 1 - <= 4 h
- Remarks on duration:
- Exposure for 1 or 4 h
- Concentrations:
- 524 mg/m^3 for 1 h exposure
243 and 520 mg/m^3 for 4 h exposure - No. of animals per sex per dose:
- 10 males and 10 females per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Necropsy of survivors performed: no - Statistics:
- LC50 was calculated via probit analysis
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 524 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 520 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No mortality occurred during the study period.
- Clinical signs:
- other: No clinical signs were observed during the study period.
- Body weight:
- Body weight was not examined during the study period.
- Gross pathology:
- Gross pathology was not performed.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the test conditions, the test material is not classified according to Regulation (EC) No. 1272/2008 (CLP) and to the GHS.
- Executive summary:
In an acute inhalation toxicity study conducted similarly to the OECD TG 403, groups of Wistar rats (10/sex) were exposed by inhalation route to the test material mixed with a solution of alcohol-Lutrol (1:1) for 1 or 4 hours to whole body at concentrations of 524 mg/m3 (1-hour exposure), 243 or 520 mg/m3 (4-hour exposure). Animals were then observed for 7 days.
No mortality occurred during the study period. No clinical signs were observed.
Combined Inhalation LC50 > 524 mg/m3 (1-hour exposure).
Combined Inhalation LC50 > 520 mg/m3 (4-hour exposure).
Under the test conditions, the test material is not classified according to Regulation (EC) No. 1272/2008 (CLP) and to the GHS.
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