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Diss Factsheets
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EC number: 605-297-6 | CAS number: 162627-18-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other: expert statement
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: No studies are available on adsorption, distribution, metabolism and excretion of WS400152. Predictions were made based on physical-chemical properties and results of toxicological studies.
- Executive summary:
The substance WS400152 is a complex mixture of components composed of fatty acids, C18-unsatd., trimers, reaction products with triethylenetetramine. Below some physical-chemical properties are listed:
- Molecular weight: approx. 700 – 1000 Da
- Water solubility: ca 1 mg/l
- Boiling point: decomposes before boiling, decomposition starts at ca. 160°C
- Log Pow: > 5.5
- Vapour pressure : 4 x 10E-3 Pa at 25°C
The available physical-chemical and toxicological information on the substance has been evaluated and used to assess the toxicokinetic behaviour.
In the ECHA document “Guidance on information requirements and chemical safety assessment Chapter R.7c: Endpoint specific guidance, 2017” guidance is provided which physical-chemical properties commonly determine dermal, oral and respiratory absorption of substances.
Dermal absorption
The test material, WS400152, is a complex mixture of components. The low water solubility (ca. 1 mg/L at 20°C), the high lipophilicity (Log10Pow> 5.5 at 25°C) and the high molecular weight (ca. 700 – 1000 Da) are expected to limit its rate of transfer between the stratum corneum and the lower epidermis and dermis after topical administration. Consequently the above physical-chemical properties of WS400152 are considered to limit its systemic availability after topical administration.
However, in view of the sensitization response attained in the Local Lymph Node Assay (LLNA) in mice at non-irritating test concentrations of WS400152 some dermal absorption must have occurred. This may have been only a small fraction of the administered test material.
Oral absorption
The test material, WS400152, is a complex mixture of components. The low water solubility (ca. 1 mg/L at 20°C), the high lipophilicity (Log10Pow> 5.5 at 25°C) and the high molecular weight (ca. 700 – 1000 Da) are expected to limit its absorption after oral administration. Consequently the above physical-chemical properties of WS400152 are considered to limit its systemic availability after oral administration.
Absorption of WS400152, or at least a small fraction thereof, after oral gavage administration is concluded from increased incidence and severity of myocardial inflammation/degeneration/fibrosis and changes in some blood plasma parameters at 1000 mg/kg/day in the repeat dose toxicity study. Adverse effects on bodyweight gain transiently were observed in male animals in this study at 1000 mg/kg/day.
Respiratory absorption
No data is available on absorption after inhalation. However, inhalation of any vapour from WS400152 is an unlikely route of human exposure, because the substance has a very low vapour pressure (4 x 10-3Pa at 25°C) and decomposes without boiling at high temperatures (≥ ca. 160°C). Exposure of humans to an inhalable aerosol of WS400152 is also unlikely, because it is a highly viscous liquid limiting its availability as an inhalable aerosol.
Distribution and metabolism
There is no indication in the available study results regarding the distribution or metabolism of WS400152 or components thereof.
Excretion
There is no information available on excretion of WS400152 in the available studies.
Bioaccumulation potential
Based on all available information no final conclusion on a bioaccumulation potential can be drawn.
Reference
Description of key information
Key value for chemical safety assessment
Additional information
The substance WS400152 is a complex mixture of components composed of fatty acids, C18-unsatd., trimers, reaction products with triethylenetetramine. Below some physical-chemical properties are listed:
- Molecular weight: approx. 700 – 1000 Da
- Water solubility: ca 1 mg/l
- Boiling point: decomposes before boiling, decomposition starts at ca. 160°C
- Log Pow: > 5.5
- Vapour pressure : 4 x 10E-3 Pa at 25°C
The available physical-chemical and toxicological information on the substance has been evaluated and used to assess the toxicokinetic behaviour.
In the ECHA document “Guidance on information requirements and chemical safety assessment Chapter R.7c: Endpoint specific guidance, 2017” guidance is provided which physical-chemical properties commonly determine dermal, oral and respiratory absorption of substances.
Dermal absorption
The test material, WS400152, is a complex mixture of components. The low water solubility (ca. 1 mg/L at 20°C), the high lipophilicity (Log10Pow> 5.5 at 25°C) and the high molecular weight (ca. 700 – 1000 Da) are expected to limit its rate of transfer between the stratum corneum and the lower epidermis and dermis after topical administration. Consequently the above physical-chemical properties of WS400152 are considered to limit its systemic availability after topical administration.
However, in view of the sensitization response attained in the Local Lymph Node Assay (LLNA) in mice at non-irritating test concentrations of WS400152 some dermal absorption must have occurred. This may have been only a small fraction of the administered test material.
Oral absorption
The test material, WS400152, is a complex mixture of components. The low water solubility (ca. 1 mg/L at 20°C), the high lipophilicity (Log10Pow> 5.5 at 25°C) and the high molecular weight (ca. 700 – 1000 Da) are expected to limit its absorption after oral administration. Consequently the above physical-chemical properties of WS400152 are considered to limit its systemic availability after oral administration.
Absorption of WS400152, or at least a small fraction thereof, after oral gavage administration is concluded from increased incidence and severity of myocardial inflammation/degeneration/fibrosis and changes in some blood plasma parameters at 1000 mg/kg/day in the repeat dose toxicity study. Adverse effects on bodyweight gain transiently were observed in male animals in this study at 1000 mg/kg/day.
Respiratory absorption
No data is available on absorption after inhalation. However, inhalation of any vapour from WS400152 is an unlikely route of human exposure, because the substance has a very low vapour pressure (4 x 10-3Pa at 25°C) and decomposes without boiling at high temperatures (≥ ca. 160°C). Exposure of humans to an inhalable aerosol of WS400152 is also unlikely, because it is a highly viscous liquid limiting its availability as an inhalable aerosol.
Distribution and metabolism
There is no indication in the available study results regarding the distribution or metabolism of WS400152 or components thereof.
Excretion
There is no information available on excretion of WS400152 in the available studies.
Bioaccumulation potential
Based on all available information no final conclusion on a bioaccumulation potential can be drawn.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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