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EC number: 241-659-6 | CAS number: 17675-60-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20-03-2017 to 29-06-2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- OECD Guidelines for Testing of Chemicals, Section 4, No. 402, “Acute Dermal Toxicity” adopted 24 Feb, 1987
- Deviations:
- yes
- Remarks:
- For technical reasons all raw data were recorded on paper.
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- Amidinourea phosphate
- EC Number:
- 241-659-6
- EC Name:
- Amidinourea phosphate
- Cas Number:
- 17675-60-4
- Molecular formula:
- C2H6N4O.xH3O4P
- IUPAC Name:
- diaminomethylideneurea;phosphoric acid
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- Batch No.: 16VL8189
Expiry Date: 03 August 2017
Storage Conditions: room temperature, protected from light
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- WISTAR Crl: WI(Han) rats
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Age at the beginning of the study: males: 9-10 weeks old; females: 9-10 weeks old
Body weight on the day of administration: males: 265 – 289 g females: 200 – 215 g
Housing and Feeding Conditions:
Full barrier in an air-conditioned room
Temperature: 22 3 °C
Relative humidity: 55 10%
Artificial light, sequence being 12 hours light, 12 hours dark
Air change: 10 x / hour
Free access to Altromin 1324 maintenance diet for rats and mice
Free access to tap water, sulphur acidified to a pH value of approximately 2.8 (drinking water,
municipal residue control, microbiological controls at regular intervals)
The animals were kept individually in IVC cages, type III H, polysulphone cages on Altromin saw
fibre bedding
Adequate acclimatisation period (at least five days) under laboratory conditions
Preparation of the Animals:
The animals were marked for individual identification by tail painting.
Approximately 25 (for males) and 24 (for females) hours before the test, the fur was removed from
the dorsal area of the trunk using an electric clipper. Care was taken to avoid abrading the skin, and
only animals with healthy intact skin were used.
No less than 10% of the body surface was cleared for the application.
Prior to the application a detailed clinical observation was made of all animals. Only healthy animals
were used.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- Approximately 25 (for males) and 24 (for females) hours before the test, the fur was removed from the dorsal area of the trunk using an electric clipper. Care was taken to avoid abrading the skin, and only animals with healthy intact skin were used.
No less than 10% of the body surface was cleared for the application.
Prior to the application a detailed clinical observation was made of all animals. Only healthy animals were used. - Duration of exposure:
- 24 hours
- Doses:
- Single dose of 2000 mg/kg body weight
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- OECD 402: All animals were observed for 14 days after dosing.
- Statistics:
- Signs of erythema and oedema were assessed using the scoring system (Table 2) laid down in OECD Guideline 404
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No test substance related deaths
- Clinical signs:
- other: No signs of toxicity for both sexes. No skin irritation for both sexes.
- Gross pathology:
- No significant findings.
Any other information on results incl. tables
Absolute Body Weights in g and Body Weight Change in %
Dose: 2000 mg/kg body weight |
||||
Animal No. / Sex |
g Day 1 |
g Day 8 |
g Day 15 |
% Day 1-15 |
21 / male |
265 |
281 |
304 |
15 |
22 / male |
273 |
291 |
317 |
16 |
23 / male |
273 |
299 |
326 |
19 |
24 / male |
289 |
307 |
350 |
21 |
25 / male |
271 |
289 |
322 |
19 |
26 / female |
206 |
211 |
217 |
5 |
27 / female |
201 |
205 |
210 |
4 |
28 / female |
205 |
203 |
224 |
9 |
29 / female |
215 |
219 |
233 |
8 |
30 / female |
200 |
210 |
214 |
7 |
Applicant's summary and conclusion
- Conclusions:
- The dermal LD50was determined to be > 2000 mg GUANYLUREA PHOSPHATE / kg body weight.
- Executive summary:
Under the conditions of the present study, single dermal application of the test item GUANYLUREA PHOSPHATE to rats at a dose of 2000 mg/kg body weight was associated with no mortality and neither signs of toxicity nor signs of irritation. The dermal LD50 was determined to be > 2000 mg GUANYLUREA PHOSPHATE / kg body weight.
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