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EC number: 277-146-9 | CAS number: 72968-71-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In an acute oral study five male and 5 female rats received a single dose of 10000 mg Termoplastrot Lm/400 (35% suspension in Carboxymethyl cellulose)/kg bw by gavage. The animals were observed for mortality, clinical signs and body weight for 14 days. A histopathological examination was performed at the end of the study. No mortalities occurred. Discriminating dose = 10000 mg/kg bw.
In an acute inhalation toxicity study twelve rats (male and female) were exposed to a dust atmosphere of Thermoplastrot Lm 74/400 for 8 hours at a concentration of 2.35 mg/L. After one week the animals were killed and dissected. No deaths occurred. Discriminating dose = 2.35 mg/L.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- Five male and 5 female rats received a single dose of 10000 mg Termoplast Lm/400 (35% suspension in Carboxymethyl cellulose)/kg bw by gavage. The animals were observed for mortality, clinical signs and body weight for 14 days. A histopathological examination was performed at the end of the study.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Specific details on test material used for the study:
- Test material name given in the report: Thermoplastrot Lm 74/400
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- other: Carboxymethylcellulose 0.5% in water
- Doses:
- 10000 mg/kg bw
- No. of animals per sex per dose:
- 5 male and 5 female rats/dose
- Control animals:
- no
- Key result
- Sex:
- male/female
- Dose descriptor:
- discriminating dose
- Effect level:
- 10 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No feaths
- Clinical signs:
- other: Faeces were coloured dark red
- Gross pathology:
- No abnormalities detected
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 > 10000 mg/kg bw (discriminating dose).
- Executive summary:
Five male and 5 female rats received a single dose of 10000 mg Termoplast Lm/400 (35% suspension in Carboxymethyl cellulose)/kg bw by gavage. The animals were observed for mortality, clinical signs and body weight for 14 days. A histopopathological examination was performed at the end of the study. No mortalities occurred. Discriminating dose = 10000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 10 000 mg/kg bw
- Quality of whole database:
- Study well documented, meets generally accepted scientific principles, acceptable for assessment.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- Twelve rats (male and female) were exposed to a dust atmosphere of Thermoplastrot Lm 74/400 for 8 hours at a concentration of 2.35 mg/L. After one week the animals were killed and dissected.
- GLP compliance:
- no
- Test type:
- concentration x time method
- Limit test:
- yes
- Specific details on test material used for the study:
- Test material name given in the report: Thermoplastrot Lm 74/400
- Species:
- rat
- Sex:
- male/female
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- For saturation respective enrichement air was conducted to a layer of 5 cm thickness into the exposure chamber.
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 8 h
- Concentrations:
- 2.35 mg/liter
- No. of animals per sex per dose:
- 12 animals (m+f)/dose
- Control animals:
- yes
- Details on study design:
- For saturation respective enrichement air was conducted to a layer of 5 cm thickness into the exposure chamber.
- Sex:
- male/female
- Dose descriptor:
- discriminating conc.
- Effect level:
- 2.35 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Mortality:
- No deaths occurred.
- Gross pathology:
- No abnormalities detected
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No deaths occurred. Discriminating dose = 2.35 mg/L.
- Executive summary:
Twelve rats (male and female) were exposed to a dust atmosphere of Thermoplastrot Lm 74/400 for 8 hours at a concenteration of 2.35 mg/L. After one week the aminals were killed and dissected. No deaths occurred. Discriminating dose = 2.35 mg/L.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating conc.
- Value:
- 2 350 mg/m³ air
- Quality of whole database:
- Study well documented, meets generally accepted scientific principles, acceptable for assessment
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In a further acute study five male and 5 female mice each, received a single i.p. dose of 2150, 3160, 4640, 6810 or 10000 mg Termoplastrot Lm/400 (35% suspension in Carboxymethyl cellulose)/kg bw by gavage. The animals were observed for mortality, clinical signs and body weight for 14 days. A histopathological examination was performed. LD50 = ca. 6800 mg/kg bw (mice, m+f).
Justification for classification or non-classification
In an acute oral toxicity study in rats a discriminating dose of 10000 mg/kg bw was found. In an acute inhalation toxicity study in rats the discriminating dose was 2.35 mg/L. A acute intraperitoneal study in mice revealed a LD50 of ca. 6800 mg/kg bw. According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification is not justified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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