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Diss Factsheets
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EC number: 945-327-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Remarks:
- Reliabality according to OECD SIDS (2004).
Data source
Reference
- Reference Type:
- other: Collection of data from published literature and company data.
- Title:
- Unnamed
- Year:
- 2 004
Materials and methods
- Principles of method if other than guideline:
- Nose-only exposure system. Five animals each per sex were used. Analysed chamber concentrations ranged from 650 to 725 mg/m3 (note:
Technically, the maximally achievable aerosol concentration due to substance-inherent properties resulting in sedimentation and adsorption to
the equipment.). About 45 % of the aerosol comprised particles with an aerodynamic diameter of <5 um (respirable fraction). - GLP compliance:
- yes
Test material
- Reference substance name:
- Silicon dioxide
- EC Number:
- 231-545-4
- EC Name:
- Silicon dioxide
- Cas Number:
- 7631-86-9
- Molecular formula:
- O2Si
- IUPAC Name:
- Silicon dioxide
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- SIPERNAT 22S >98 % (SiO2): CAS-Name: Silica, precipitated, cryst.-free; CAS-No.: 112926-00-8. Surface area: 160 - 195 m2/g.
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- nose only
- Vehicle:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- Maximum attainable concentration: 691 mg/m3. Analysed chamber concentrations ranged from 650 to 725 mg/m3.
- No. of animals per sex per dose:
- Five animals each per sex.
- Control animals:
- not specified
- Details on study design:
- Analysed chamber concentrations ranged from 650 to 725 mg/m3 (Technically, the maximally achievable aerosol concentration due to substance-inherent properties resulting in sedimentation and adsorption to
the equipment.). About 45 % of the aerosol comprised particles with an aerodynamic diameter of <5 um (respirable fraction).
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- > 0.691 mg/L air
- Mortality:
- None
- Clinical signs:
- other: No clinical symptoms except some restlessness and eye closing.
- Body weight:
- No clinical symptoms except some restlessness and eye closing. Body weight gain was not affected in males, but females hardly gained weight
during two days after exposure, however, subsequently, showed normal development. - Gross pathology:
- No findings at autopsy after 14 d post-treatment.
Applicant's summary and conclusion
- Conclusions:
- Acute inhaltation toxicity of synthetic amorphous silicon dioxide (precipitated) in rat: LC0 (4 h) >0.691 mg/L.
- Executive summary:
An acute inhaltation toxicity study with precipitated synthetic amorphous silicon dioxide was performed using rat as a test organism. Analysed chamber concentrations ranged from 650 to 725 mg/m3 (maximum attainable concentration was 691 mg/m3). No clinical symptoms except some restlessness and eye closing. Body weight gain was not affected in males, but females hardly gained weight during two days after exposure, however, subsequently, showed normal development. No findings at autopsy after 14 d post-treatment.
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