N-(2-hydroxyethyl)dodecanamide

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

17 August 2017 - TBC

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

Study was conducted in accordance with international guidelines and in accordance with GLP. All guideline validity criteria were met.

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Version / remarks:

Regulation (EC) 440/2008 of 30 May 2008

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Version / remarks:

27 July 1995

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Key result

Boiling pt.:

>= 251 - <= 372 °C

Atm. press.:

101 kPa

Decomposition:

no

Experimental Apparatus:

Instrument:                            Mettler Toledo DSC822e Differential Scanning Calorimeter (DSC) incorporating a ThermoHaake Cooler EK45/MT.

Software:                                Mettler Toledo STARe v12.10

Sample crucibles:                   Aluminium crucible with lid.

Reference crucible:                Empty aluminium crucible with lid.

Test conditions:                      The test was performed in an air atmosphere.

 

 

Performance of the Test:

The temperature accuracy of the DSC was checked prior to testing with indium and zinc. These were within defined tolerances and the DSC was therefore considered acceptable for use. Aliquots of test item were placed in crucibles and were subjected to a thermal program as shown in the following table:

 

Table 1:          Experimental Conditions

Determination	Mass Taken (g)	Crucible Lid	Temperature Program	Atmosphere
Preliminary/Screen	0.0044	Once pierced	20 to 450 °C at 20 °C/min	Air
1	0.0055	Pre-pierced	20 to 450 °C at 20 °C/min	Air
2	0.0047	Pre-pierced	20 to 450 °C at 20 °C/min	Air

 

The appearance of the samples (residue) was recorded after the test.

 

Evaluation of Data:

The standard boiling point is defined as the point at which the vapor pressure of a liquid is the same as the standard pressure (101.325 kPa). During thermal analysis, the peak width of an endothermic reaction also depends on sample amount and heating rate. Therefore, the onset point of the relevant endothermic peak is usually stated as the boiling point. The boiling point is stated with regard to the ambient pressure during measurement. Measured temperatures were converted from °C to K using Equation 1.

 

Equation 1:                                                                             T = t + 273.15

 

where:

T = Thermodynamic temperature, Kelvin (K)

t = Celsius temperature, degrees Celsius (°C)

 

 

Results:

Table 2:          Thermographic Data

Thermal Event	Interpretation	Temperature
		Preliminary/Screen		Determination 1		Determination 2
		°C	K	°C	K	°C	K
Endotherm (left limit)	Start of boiling	253	527	261	534	251	524
Endotherm (right limit)	End of boiling	398	671	372	645	371	644

After heating to 450 °C, the crucibles from determination 1 and 2 had lost 87 and 100% of their original mass respectively.

 

The residue in the crucibles from determinations 1 and 2 was observed to be a small amount of black solid white solid around the periphery.

 

Boiling range: Approximately 251 to 372 °C (524 to 645 K)

 

 

Conclusion:

The test item was determined to boil in the range of approximately 251 to 372 °C (524 to 645 K) at 101.0 kPa.

Conclusions:

The test item was determined to boil in the range of approximately 251 to 372 °C (524 to 645 K) at 101.0 kPa.

Executive summary:

EU Method A.2. – The boiling point of the test item was sought using the Differential Scanning Calorimeter (DSC) method.  The procedure employed was designed to be compatible with Method A.2. Boiling Temperature of Commission Regulation (EC) No 440/2008 of 30 May 2008.

Two determinations were carried out.  Aliquots of test item (0.0047 – 0.0055 g) were placed in an aluminium crucible and subjected to a thermal programme of 20 °C/min between 20 to 450 °C.

The test item was determined to boil in the range of approximately 251 to 372 °C (524 to 645 K) at 101.0 kPa.

Description of key information

Boiling Point: Boiling range = 251 to 372 °C (524 to 645 K) at 101.0 kPa; EU Method A.2.; R. Butler (2018)

Key value for chemical safety assessment

Boiling point at 101 325 Pa:

251 °C

Additional information

EU Method A.2. – The boiling point of the test item was sought using the Differential Scanning Calorimeter (DSC) method.  The procedure employed was designed to be compatible with Method A.2. Boiling Temperature of Commission Regulation (EC) No 440/2008 of 30 May 2008.

Two determinations were carried out.  Aliquots of test item (0.0047 – 0.0055 g) were placed in an aluminium crucible and subjected to a thermal programme of 20 °C/min between 20 to 450 °C.

The test item was determined to boil in the range of approximately 251 to 372 °C (524 to 645 K) at 101.0 kPa.