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Diss Factsheets
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EC number: 701-212-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 2, 2010
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
- Reference Type:
- publication
- Title:
- An Alternative to Draize Test.
- Author:
- Kemper, F.H. & Luepke, N.P.
- Year:
- 1 986
- Bibliographic source:
- FD Chem. Toxic. 24, p 495-496.
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: HET-CAM test (Kemper and Luepke, 1986)
- Principles of method if other than guideline:
- The chorioallantoic membrane of the chick embryo, were used as it has been shown to respond to injury with a complete inflammatory reaction that corresponds with that of the rabbit eye. Please refer to attached full test report for additional details on the methods.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Fatty acids, C16-18 (even numbered) and C18 (unsaturated) (9Z)-octadec-9-enyl esters.
- EC Number:
- 701-212-2
- Cas Number:
- 869110-10-1
- Molecular formula:
- R1, R2, R3: C15-, C17- saturated, C17- unsaturated alkyl chains
- IUPAC Name:
- Fatty acids, C16-18 (even numbered) and C18 (unsaturated) (9Z)-octadec-9-enyl esters.
1
- Specific details on test material used for the study:
- Lipex Shea WM, 50% in Akosun Batch 1019002-A
Test animals / tissue source
- Species:
- chicken
- Strain:
- other: Hen's Egg Test
- Details on test animals or tissues and environmental conditions:
- Fresh, fertile White Leghorn eggs were obtained from Meyer's Chickc, Inc., in Quakertown, Pennsylvania. Please see attached full test report for further details.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- 0.3 ml
- Duration of treatment / exposure:
- 20 seconds
- Observation period (in vivo):
- 30 sec, 2 and 5 minutes after exposure
- Number of animals or in vitro replicates:
- 4 in each group
- Details on study design:
- Please see the attached test report for further details.
Results and discussion
In vitro
Resultsopen allclose all
- Irritation parameter:
- other: CAM effects score
- Remarks:
- Please see table below and attached report
- Run / experiment:
- 0.5 min
- Value:
- 0
- Positive controls validity:
- valid
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other: CAM effect score
- Remarks:
- Please see table below and attached report
- Run / experiment:
- 2 min
- Value:
- > 0 - <= 3
- Positive controls validity:
- valid
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other: CAM effects score
- Remarks:
- Please see table below and attached report
- Run / experiment:
- 5 min
- Value:
- > 0 - <= 1
- Positive controls validity:
- valid
- Remarks on result:
- no indication of irritation
Any other information on results incl. tables
Reactions of the CAMs, the blood vessels including the cappilaries, and the albumin were examined for irritant effects and scored as seen below:
Score | ||||
Effect | time (min) | 0.5 | 2 | 5 |
Hyperemia |
|
5 |
3 |
1 |
Minimal hemorhage ("feathering" |
|
7 |
5 |
3 |
Hemorhage (obvoius bleeding) |
|
9 |
7 |
5 |
Coagulation and/or thrombosis |
|
11 |
9 | 7 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance is not an eye irritant.
- Executive summary:
The substance was tested for eye irritability in the hens egg's test. The test was performed on the chorioallantoic membrane of the chick embryo, as it has been shown to respond to injury with a complete inflammatory reaction that corresponds with that of the rabbit eye. Based on the study, it is concluded that the substance would have practically no ocular irritaion potential in vivo.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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