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Physical & Chemical properties

Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017-10-18 to 2018-02-14
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
Qualifier:
according to guideline
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Qualifier:
according to guideline
Guideline:
other: CIPAC MT 187: Particle Size Analysis by Laser Diffraction
GLP compliance:
no
Type of method:
Laser scattering/diffraction
Type of particle tested:
agglomerate
Type of distribution:
volumetric distribution
Mass median aerodynamic diameter:
41.7 µm
Geometric standard deviation:
1.83
Percentile:
D50
Mean:
41.7 µm
St. dev.:
1.83
Percentile:
D10
Mean:
10.9 µm
St. dev.:
0.59
Percentile:
D90
Mean:
198.9 µm
St. dev.:
15.9

Median particle size D (v, 0.5): 50% of particle volume or particle mass with lower particle diameter

1st test series: 40.5 µm

2nd test series: 42.9 µm

Average of the median particle size: 41.7 µm

Particle size D (v, 0.1): 10% of particle volume or particle mass with lower particle diameter

1st test series: 10.4 µm

2nd test series: 11.4 µm

Average of the particle size: 10.9 µm

Particle size D (v, 0.9): 90% of particle volume or particle mass with lower particle diameter

1st test series: 190.4 µm

2nd test series: 207.5 µm

Average of the particle size: 198.9 µm

The test item consisted of agglomerated partially transparent particles. The particle size distribution showed a polymodal distribution. Maxima were observed at approx. 2 µm, 30 µm, and 1000 µm. The maximum at 30 µm had a shoulder at approx. 100 µm. From microscopic images, it could not be clarified whether the D (v, 0.9) value and the maximum at 1000 µm is determined by primary particles or agglomerates.

Conclusions:
The particle size distribution of the test item 5’-O-(4,4’-Dimethoxytrityl)thymidine was determined by laser diffraction (light scattering):
Average of the median particle size D (v, 0.5): 41.7 µm (standard deviation 1.83 µm)
Average of the particle size D (v, 0.1): 10.9 µm (standard deviation 0.59 µm)
Average of the particle size D (v, 0.9): 198.9 µm (standard deviation 15.9 µm)
Executive summary:

The particle size distribution of the test item 5’-O-(4,4’-Dimethoxytrityl)thymidine was determined by laser diffraction (light scattering):

Average of the median particle size D (v, 0.5): 41.7 µm (standard deviation 1.83 µm)

Average of the particle size D (v, 0.1): 10.9 µm (standard deviation 0.59 µm)

Average of the particle size D (v, 0.9): 198.9 µm (standard deviation 15.9 µm)

Description of key information

The particle size distribution of the test item 5’-O-(4,4’-Dimethoxytrityl)thymidine was determined by laser diffraction (light scattering):

Average of the median particle size D (v, 0.5): 41.7 µm (standard deviation 1.83 µm)

Average of the particle size D (v, 0.1): 10.9 µm (standard deviation 0.59 µm)

Average of the particle size D (v, 0.9): 198.9 µm (standard deviation 15.9 µm)

Additional information