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Reaction mass of N,N-ethanediylbis- Hexadecanamide, N-[2-[(1-oxohexadecyl)amino]ethyl]-Octadecanamide, Hexadecanoic acid, 12-hydroxystearic acid, reaction products with ethylenediamine, N,N-ethanediylbis-Octadecanamide and Octadecanoic acid, 12-hydroxystearic acid, reaction products with ethylenediamine
EC number: 906-763-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption
- Remarks:
- other: calculation
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically acceptable calculation
- Principles of method if other than guideline:
- Calculated using KOCWIN v2.00, a subroutine of the computer program EPI Suite™ (Estimation Program Interface for Windows, version 4.0. Syracuse Research Corporation, Syracuse, NY, USA) U.S. Environmental Protection Agency, OPPT
- GLP compliance:
- no
- Type:
- Koc
- Value:
- >= 404 300 000 - <= 814 300 000
- Type:
- log Koc
- Value:
- > 8.6 - < 8.91
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- other: expert statement
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Expert statement about Guideline Study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- yes
- Details on test conditions:
- Instrument Alliance Separation Module 2695
(Waters, Milford, MA, USA)
Detector Photodiode Array Detector 996 (Waters)
Column Hypersil BDS-CN, 150 mm 4.6 mm i.d., dp = 5 µm (Thermo Fisher Scientific, San Jose, CA, USA)
Column temperature 35°C 1°C
Mobile phase 55/45 (v/v) methanol/water
Flow 1 ml/min
Injection volume 10 µl
UV detection 210 nm
Reagents: Water, Methanol, Acetonitrile, Dimethylsulfoxide, Tetrahydrofuran, n-Hexan, Toluen, 2-Propanol, Chloroform.
All of the above reagents were used to dissolve the test substance. When using methanol, acetonitrile, dimethylsulfoxide, tetrahydrofuran, n-hexane and toluene, the test substance solutions were also sonicated for 10 to 20 minutes. The test substance did not dissolve - Endpoint:
- adsorption / desorption: screening
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- refers to chapter 13
- Reason / purpose for cross-reference:
- read-across source
- Details on test conditions:
- Instrument Alliance Separation Module 2695
(Waters, Milford, MA, USA)
Detector Photodiode Array Detector 996 (Waters)
Column Hypersil BDS-CN, 150 mm 4.6 mm i.d., dp = 5 µm (Thermo Fisher Scientific, San Jose, CA, USA)
Column temperature 35°C 1°C
Mobile phase 55/45 (v/v) methanol/water
Flow 1 ml/min
Injection volume 10 µl
UV detection 210 nm
Reagents: Water, Methanol, Acetonitrile, Dimethylsulfoxide, Tetrahydrofuran, n-Hexan, Toluen, 2-Propanol, Chloroform.
All of the above reagents were used to dissolve the test substance. When using methanol, acetonitrile, dimethylsulfoxide, tetrahydrofuran, n-hexane and toluene, the test substance solutions were also sonicated for 10 to 20 minutes. The test substance did not dissolve
Referenceopen allclose all
The test substance exhibits adsorption potential to soil and sediment
When using methanol, acetonitrile, dimethylsulfoxide, tetrahydrofuran, n-hexane and toluene, the test substance solutions were also sonicated for 10 to 20 minutes. The test substance did not dissolve.
Heating was used when trying to dissolve the test substance in 2-propanol and/or chloroform using a hot plate at 50-55°C. The test substance did not dissolve.
Based on these experiments, it was concluded that there was no suitable reagent to dissolve the test substance which is compatible with the conditions to be used for estimation of the adsorption coefficient by HPLC.
In orer to test if any test substance was dissolved in 2-propanol, an injection on an analytical system was performed. HPLC chromatograms of the test substance solution and corresponding blank solution are performed. No differences can be observed between the test substance and blank injection, indicating the negligible amount of dissolved material.
In addition, an injection without HPLC column of the blank and test substance solution was also performed. No difference compared to the blank could be observed in the chromatogram.
When using methanol, acetonitrile, dimethylsulfoxide, tetrahydrofuran, n-hexane and toluene, the test substance solutions were also sonicated for 10 to 20 minutes. The test substance did not dissolve.
Heating was used when trying to dissolve the test substance in 2-propanol and/or chloroform using a hot plate at 50-55°C. The test substance did not dissolve.
Based on these experiments, it was concluded that there was no suitable reagent to dissolve the test substance which is compatible with the conditions to be used for estimation of the adsorption coefficient by HPLC.
In orer to test if any test substance was dissolved in 2-propanol, an injection on an analytical system was performed. HPLC chromatograms of the test substance solution and corresponding blank solution are performed. No differences can be observed between the test substance and blank injection, indicating the negligible amount of dissolved material.
In addition, an injection without HPLC column of the blank and test substance solution was also performed. No difference compared to the blank could be observed in the chromatogram.
Description of key information
Since the Constituent Amides, C16-C18 (even), N,N'-ethylenebis did not dissolve in (organic) solvents at sufficiently high levels, the adsorption coefficient could not be determined. Calculated log KOC (KOCWIN v2.00) values for the substance were 8.6 and 8.91. Thus, it has potential for adsorption to soil and sediment but this is a worst case approach for Amides, C16-C18 (even), N,N'-ethylenebis.
A calculation with the main constituents came to a range of an Log Koc of 6.8 to 8.6. Therefore the obove QSAR can be used as the worstcase situation.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.