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EC number: 916-331-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
For assessing the acute fish toxicity of Cyclabute information from Cyclobutanate is used. The read across documentation can be found in the Aquatic toxicity Endpoint summary. The executive summary of the acute fish toxicity with Cyclobutanate and Cyclaprop are presented below.
Acute fish toxicity with Cyclobutanate
Cyclabute has an isobutyl group attached to the ester, while Cyclobutanate has a straight chain alkyl ester (see for further read across documentation the Endpoint summary). The acute toxicity of Cyclobutanate towards Oncorhynchus mykiss was investigated according to OECD guideline 203 under GLP. Fish were exposed to time-weighted average mean measured concentrations of 0.85, 1.4, 2.7, 4.9 and 11.0 mg/l and observed for 96 hours in a semi-static test setup. The test material solutions were prepared by stirring an excess (100 mg/l) of test material in dechlorinated tap water for a period of 48 hours prior to removing any undissolved test material by filtration (0.2 µm). This "saturated" solution was then further diluted, as necessary, to provide the remaining test groups. Sub-lethal effects of exposure were observed at the time-weighted mean measured test concentrations of 2.7, 4.9 and 11.0 mg/1. At the time-weighted mean measured test concentration of 4.9 mg/1 between 24 and 48 hours 7 fish were observed to be moribund. At the time-weighted mean measured test concentration of 11.0 mg/1 after 1.5 hours all 10 fish were observed to be moribund. A steep dose-response curve was visible. A decline in measured test concentrations was shown despite the use of sealed vessels with minimal headspace and no aeration in an attempt to minimise losses due to the volatile nature of the test material. Given the decline in the measured test concentrations (10 -70% loss was seen in 24 hours) it was considered justifiable to base the results of the definitive test on the time-weighted mean measured test concentrations in order to give a "worst case" analysis of the data. The 96-Hour LC50 based on the time-weighted mean measured test concentrations was 3.6 mg/1 with 95% confidence limits of 2.7- 4.9 mg/1 (concentrations resulting in 0% and 100% mortality respectively).
Acute fish toxicity with Cyclaprop
The acute toxicity of Cyclaprop towards Pimephales promelas was investigated according to OECD guideline 203 under GLP. Fish were exposed to nominal concentrations of 2.4, 5.3, 12, 25 and 56 mg/l under flow-through conditions and observed for 96 hours. Based on mean measured concentrations, the 96h-LC50 was found to be 6.7 mg/l. The test concentrations where oily-slick was observed coincide with the concentrations at which mortality was found. Physical hindrance may therefore have contributed to the effects found. It is however, difficult to make a distinction between physical and systemic effects and therefore as a worst case approach the mortality is assumed to result from systemic toxicity.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 3.6 mg/L
Additional information
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